Thread: Gynecomastia- sharing some info

Did some research on it. Just wanted to share it with anyone that maybe looking. As a small side note some of the drugs included in the treatment can be used for PCT as well. I was going to do on article on both PCT and Gyno before I realized they're really too different to lump together even though some of the treatments are the same. Its not well written and copied a lot but at least it's all in one place. Please feel free to leave any comments by adding on or correcting me if I'm wrong.

Gynecomastia
- the development of abnormally large mammary glands in males resulting in breast enlargement. it has generally been attributed to an imbalance of sex hormones or the tissue responsiveness to them. Breast prominence can result from hypertrophy of breast tissue, chest adipose tissue(*fat tissue) and skin, and is typically a combination

-pseudogynecomastia -Breast prominence due solely to excessive adipose/fat tissue and not because of hormones

general information:
Growing glandular tissue, typically from some form of hormonal stimulation, is often tender or painful. Weight loss can alter the condition in cases where it is triggered by obesity, but losing weight will not reduce the glandular component and patients cannot target areas for weight loss.

Types of gynecomastia:
There are multiple manifestations of gynecomastia. The following types have the same basic features of gynecomastia-
--Puffy Nipples is among the most common forms of gynecomastia. This glandular tissue accumulation is concentrated under and typically confined to the areola, or can be slightly extended outside the areola forming a dome shaped appearance to the areola.
-- Pure Glandular In bodybuilders this may be a result of the use of anabolic steroids. Due to their low level of body fat, bodybuilders and other athletes are sometimes afflicted with gynecomastia in its purest form. Gynecomastia in lean men is usually only a breast tissue gland with little to no adipose tissue. Proper treatment of pure gynecomastia can be done only by excision (meaning surgical removal) of the breast tissue, which in the case of bodybuilders is by itself sufficient to achieve a flat nipple-areola complex. Liposuction is only rarely necessary.
--Adult The most common form of gynecomastia. Gynecomastia in most adults is composed of glandular tissue but may contain varying quantities of adipose and fibrous tissue.

Treatment[/SIZE]
Treating the underlying cause of the gynecomastia may lead to improvement in the condition.
Selective estrogen receptor modulator medications, such as tamoxifen and clomiphene, or androgens (typically bio-identical testosterone) or aromatase inhibitors such as Letrozole are medical treatment options, although they are not universally approved for the treatment of gynecomastia. Endocrinological attention may help during the first 2–3 years. After that window, however, the breast tissue tends to remain and harden, leaving surgery (either liposuction, gland excision, skin sculpture, reduction mammoplasty, or a combination of these surgical techniques) the only treatment option.

Drugs
Selective Estrogen Receptor Modulators (SERMs) are a class of compounds that act on the estrogen receptor.
The actions of SERMs on various tissues:
[B]Breast -[/B]tamoxifen is mainly used for its ability to inhibit growth in estrogen receptor
Pituitary gland - clomifene blocks estrogen action


Tamoxifen
- was discovered by ICI Pharmaceuticals[2] (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen.". Tamoxifen is the drug of choice to combat this condition for many body builders and has great results both for PCT and to help reduce the symptoms of Gyno when using AAS.

Chrysin,
- derived from Passiflora caerulea plants, does appear to block aromatase enzymes from converting testosterone to estrogen. Apparently, though, effectiveness requires a large dose of chrysin. This is compounded by the fact that chrysin is poorly absorbed, so getting an effective dose is difficult, if not impossible.

Formestane
- -(4-hydroxyandrostenedione) is a "suicide inhibitor" of aromatase. This means that it binds to it, making it inactive, and doesn't let go until the aromatase is destroyed. There are numerous studies to support manufacturing claims to its effectiveness, and the anecdotal evidence is also very good.

6-OXO
- Another suicide-type estrogen inhibitor is (4-androstene-3, 6, 17-trione). It works in a similar fashion to Formestane


Topic not included but have great material on:
How to prevent gyno-
How to prevent gyno from happening?

good post