Thread: Why do steroids quit working in 8-10 weeks on cycle?

Very good artical.

True, a major cause of gains slowing.

So you have 3 options. Stop, stay on at same dose for much longer, or increase your doses.

Increase doses and start rotating your gears to more powerful ones.

Start at a lower dose and work up to a moderate one for a longer cycle....doesn't take much to see gains.

i was wondering ,if you can do a low dose of test for a long time, if so how long.and at what dose.

Every year, for a 6 month period i do a 600mg a week dose of test and it works great for me never had a problem all my blood levels are great make great gains for the first 3 months than it stays flat!

Originally Posted by heavyiron

From Dr. Pangloss;

The following may be the answer (tentatively). this report on myostatin (a powerful muscle growth inhibitor) shows that after 8 weeks on Testoterone, myostatin levels rise significantly. Fortunately it's dependent on Testosterone levels and not muscle mass. When you stop the Test, myostatin levels go back to normal....

8-10 weeks is when the gains from a cycle peeter out. Wish i had some solutble activinIIB receptor or myo-29 antibody to knock that shit off....


: Mol Cell Endocrinol. 2009 Apr 10;302(1):26-32. Epub 2009 Jan 21. Links

Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.

Lakshman KM, Bhasin S, Corcoran C, Collins-Racie LA, Tchistiakova L, Forlow SB, St Ledger K, Burczynski ME, Dorner AJ, Lavallie ER.
Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States.
Methodological problems, including binding of myostatin to plasma proteins and cross-reactivity of assay reagents with other proteins, have confounded myostatin measurements. Here we describe development of an accurate assay for measuring myostatin concentrations in humans. Monoclonal antibodies that bind to distinct regions of myostatin served as capture and detector antibodies in a sandwich ELISA that used acid treatment to dissociate myostatin from binding proteins. Serum from myostatin-deficient Belgian Blue cattle was used as matrix and recombinant human myostatin as standard. The quantitative range was 0.15-37.50 ng/mL. Intra- and inter-assay CVs in low, mid, and high range were 4.1%, 4.7%, and 7.2%, and 3.9%, 1.6%, and 5.2%, respectively. Myostatin protein was undetectable in sera of Belgian Blue cattle and myostatin knockout mice. Recovery in spiked sera approximated 100%. ActRIIB-Fc or anti-myostatin antibody MYO-029 had no effect on myostatin measurements when assayed at pH 2.5. Myostatin levels were higher in young than older men (mean+/-S.E.M. 8.0+/-0.3 ng/mL vs. 7.0+/-0.4 ng/mL, P=0.03). In men treated with graded doses of testosterone, myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men. Myostatin levels were not significantly associated with lean body mass in either young or older men. CONCLUSION: Myostatin ELISA has the characteristics of a valid assay: nearly 100% recovery, excellent precision, accuracy, and sufficient sensitivity to enable measurement of myostatin concentrations in men and women.
PMID: 19356623 [PubMed - in process]

Good Read
ty

You can do a low dose of Test the rest of your days pal.

Originally Posted by TrojanMan60563

Start at a lower dose and work up to a moderate one for a longer cycle....doesn't take much to see gains.

I agree 100%, sorry I am very new here but this post caught my eye. with every cycle there is a time were you hit a Flat spot/stop getting gains and you are at a level were adding more juice is just going to be a waste of cash then its time to take a break. Anyone that has been in the game for some time knows what I am talking about. No matter what your body can only utilize so much synthetic test in a 24 hour period and that’s it. I did see some things on staggering gear which is always great and DIET, I just think people look at gear as the perfect fix, NOT. Good diet changing up you training routine and knowing when it just time to take a break. I have been training hard for 23 years and still always find a way to get a little gain here and there. Well just my 2 cents.

Nice boobs opps guns i ment!!

Great info!

would upping the doses work to keep gaining?

Originally Posted by Crank

would upping the doses work to keep gaining?

YES! It was already mentioned in an above post

Just PM HeavyIron for some Pyramid Advice. Doing such will keep the gains coming long into a cycle.

If not, then Swith to quick Ester roids and use them for 8-10 weeks then Cruise.


GICH!

When I die I want to come back as a Bully Whippet.

Or maybe you can just back-load an oral towards the end of your cycle instead of upping the test.

Originally Posted by Crank

would upping the doses work to keep gaining?

If timed properly, yes.

Originally Posted by alphabolic

Or maybe you can just back-load an oral towards the end of your cycle instead of upping the test.

Yup, that will work as well.

Not trying to discredit Heavy here or anyone else.
Been on cycle 20 weeks still making steady gains.
Just have to fix my diet every few lb i gain.

Originally Posted by blazeftp

Not trying to discredit Heavy here or anyone else.
Been on cycle 20 weeks still making steady gains.
Just have to fix my diet every few lb i gain.

At 20 weeks myostatin is at baseline so you should be gaining with proper nutrition.

Also some guys have a lower myostatin response, ie genetics.

this should be another sticky !! good info

i cycle for 6mnths at a clip,,i see a plateau effect after 3 mnths ,,but you arent losing are ya!!! cranks got it just increase doses.also a little humilin n works wonders,5 iu per day.

Originally Posted by alphabolic

Or maybe you can just back-load an oral towards the end of your cycle instead of upping the test.

Or do both...

Originally Posted by heavyiron

At 20 weeks myostatin is at baseline so you should be gaining with proper nutrition.

Also some guys have a lower myostatin response, ie genetics.

So it would be beneficial to add a supplement such as myostatin when going on a long cycle?

So the study shows the rusults will fade away after 8-10 weeks, and this applies to all gear but EQ? i mean my experience and everyone else suggest it will start working after 10-12 of use and best results are around 16 or more weeks.

your a wealth of information man! thanks for the article

Originally Posted by blazeftp

So it would be beneficial to add a supplement such as myostatin when going on a long cycle?

Myostatin is a powerful growth inhibitor (bad for growth). It raises when you use testosterone to keep your body in homeostasis. However it falls to baseline if you stay on.

Originally Posted by GMO

Or do both...

This is the type of thinking I like...

Originally Posted by heavyiron

Myostatin is a powerful growth inhibitor (bad for growth). It raises when you use testosterone to keep your body in homeostasis. However it falls to baseline if you stay on.

So in theory you dont would not need to increase dosage to continue seeing gains? Just stay on long enough for your myostatin to fall back to baseline?