Thread: ~Aromasin Info~

Interesting study that shows after ten days administration of 25mg aromasin ed led to a significant decrease in IGF-1 and IGFBP-3. IGFBP-3 is thought to be very important IGF-1's autocrine/paracrine action(direct localized effect in tissues such as skeletal muscle). However, at the 50mg dose it did not. In fact, it raised them. What is interesting is that levels of estrodiol, esterone, testosterone, and androstenedione did not change. Though triglycerides and cholesterol were negatively effect at 50mg ed. Aromasin also increased LH,FSH, testosterone, and androtenedione significantly after a single dose. This clearly shows it's benefit in PCT.

Also important to note, is that after a single 25mg dose estrodiol levels began to rise again shortly before 24 hours after administration and significantly by 48 hours. This suggests ed dosing to be better than eod dosing to avoid uneven blood levels.

A BIG side note, the study reports the half life to be only 8.9 hours in men, where as most places report the half life to be 27 hours which has been the case in women which the majority of studies have been performed. Apparently men metabolize this drug differently.

See attachments for charts.

TABLE 2. Changes in hormone and lipid concentrations in study I: young male subjects received 25 or 50 mg exemestane daily for 10 days

Assay Dose (mg) n Baseline (mean ± SD) End of 10-d treatment (mean ± SD) % Change from baseline (mean ± SD) P value (end - baseline)

MG n BL End of 10d treatment % change P value
Free testosterone (ng/dl) 25 11 9.5 ± 3.3 19.1 ± 4.7 117.0 ± 73.9 0.0001
50 10 8.2 ± 2.9 19.4 ± 4.5 153.6 ± 94.6 0.0000
DHEAS (ng/ml) 25 11 1561 ± 826 1662 ± 726 18.6 ± 39.9 0.4227
50 9 1771 ± 909 1876 ± 840 2.8 ± 12.5 0.7804
Cortisol (µg/dl) 25 9 10.2 ± 3.4 13.1 ± 2.7 37.9 ± 39.5 0.0080
50 9 11.8 ± 6.6 11.3 ± 3.5 34.2 ± 104.0 0.7781
SHBG (nmol/liter) 25 10 22 ± 7 18 ± 5 -20.6 ± 7.0 0.0003
50 10 28 ± 20 19 ± 5 -18.9 ± 39.2 0.1756
IGF-I (ng/ml) 25 11 533 ± 137 455 ± 80 -12.5 ± 11.1 0.0075
50 10 491 ± 149 471 ± 118 2.0 ± 19.4 0.8197
IGFBP-3 (ng/liter) 25 11 5.0 ± 0.9 4.6 ± 0.6 -7.0 ± 12.5 0.0878
50 10 4.8 ± 0.5 4.7 ± 0.6 0.2 ± 8.1 0.9776
Triglycerides (mg/dl) 25 11 89.9 ± 57.8 86.2 ± 49.4 -0.8 ± 26.4 0.5821
50 10 118.5 ± 145.1 93.6 ± 51.1 28.0 ± 60.3 0.5634
Cholesterol (mg/dl) 25 11 144 ± 11 142 ± 17 -1.3 ± 9.3 0.6513
50 10 139 ± 15 145 ± 14 4.2 ± 6.3 0.0725
Cholesterol HDL (mg/dl) 25 11 42 ± 11 42 ± 12 -1.0 ± 7.4 0.6938
50 10 43 ± 11 41 ± 11 -4.1 ± 13.0 0.2796
Cholesterol LDL (mg/dl) 25 11 107 ± 16 106 ± 15 0.4 ± 15.6 0.8423
50 10 96 ± 25 108 ± 13 20.7 ± 48.1 0.1381

I can't get the damn chart to stay neat!! It keeps bunching back up.

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe

Nemours Children’s Clinic and Research Programs (N.M., J.L., A.R.), Jacksonville, Florida 32207; and University of Florida Health Sciences Center (D.P.) and Amersham Pharmacia Biotech (E.d.S., A.K., B.L.), Peapack, New Jersey 07977

http://jcem.endojournals.org/cgi/con...urcetype=HWCIT

I know more than one person that use it on cycle and tested estradiol and it was still high. Wondering if it's too weak a drug in men to control estrogens when superphysiologic doses of aromatizing compounds are being used.

edit: The number of individuals in this study was very low. It is difficult to believe that many of the data are significant at all. Most of the error exceed the average measured values. I would certainly take this study with a grain of salt.