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Interesting new use/research on Bromocryptine
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10-31-2010, 07:12 PM #1Chemistry Experiment ADMINISTRATOR
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Interesting new use/research on Bromocryptine
Bromocriptine: old drug, new formulation and new indication.
Diabetes Obes Metab. 2010 Dec;12(12):1048-57. doi: 10.1111/j.1463-1326.2010.01304.
Holt RI, Barnett AH, Bailey CJ.
Endocrinology and Metabolism Sub-division, Developmental Origins of Adult Health and Disease Division, University of Southampton School of Medicine, Southampton, UK Division of Clinical and Experimental Medicine, University of Birmingham and Heart of England NHS Foundation Trust, Birmingham, UK Life and Health Sciences, Aston University, Birmingham, UK.
Abstract
Bromocriptine is an ergot alkaloid dopamine D(2) receptor agonist that has been used extensively in the past to treat hyperprolactinaemia, galactorrhoea and Parkinsonism. It is known that hypothalamic hypodopaminergic states and disturbed circadian rhythm are associated with the development of insulin resistance, obesity and diabetes in animals and humans. When administered in the early morning at the start of the light phase, a new quick release (QR) formulation of bromocriptine appears to act centrally to reset circadian rhythms of hypothalamic dopamine and serotonin and improve insulin resistance and other metabolic abnormalities. Phase II and III clinical studies show that QR-bromocriptine lowers glycated haemoglobin by 0.6-1.2% (7-13 mmol/mol) either as monotherapy or in combination with other antidiabetes medications. Apart from nausea, the drug is well tolerated. The doses used to treat diabetes (up to 4.8 mg daily) are much lower than those used to treat Parkinson's disease and have not been associated with retroperitoneal fibrosis or heart valve abnormalities. QR-bromocriptine (Cycloset™) has recently been approved in the USA for the treatment of type 2 diabetes mellitus (T2DM). Thus, a QR formulation of bromocriptine timed for peak delivery in the early morning may provide a novel neurally mediated approach to the control of hyperglycaemia in T2DM.
© 2010 Blackwell Publishing Ltd.
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10-31-2010, 07:22 PM #2Performance Enhanced ELITE MEMBER
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10-31-2010, 07:30 PM #3Chemistry Experiment ADMINISTRATOR
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QR-bromocriptine (Cycloset™) has recently been approved in the USA for the treatment of type 2 diabetes mellitus (T2DM). Thus, a QR formulation of bromocriptine timed for peak delivery in the early morning may provide a novel neurally mediated approach to the control of hyperglycaemia in T2DM.
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10-31-2010, 08:08 PM #4Performance Enhanced ELITE MEMBER
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Ha ha, dude I'm so lost
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10-31-2010, 08:09 PM #5Is Doin It 4 Da Shorteez
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makes sense....
Bromocriptine by Lyle McDonald | BodyRecomposition - The Home of Lyle McDonald
Lyle had me taking that many years ago when I was on a cutting cycleI train differently than most, my beef is with gravity the weights on the bar are just the medium...Thanks to Wall Street your slice of the American Pie has been reduced to a crumb.
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10-31-2010, 08:15 PM #6Chemistry Experiment ADMINISTRATOR
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Bromocriptine is good for diabetes because it may control hyperglycemia.
Originally Posted by rippedgolfer
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