Any truth to this?

**maxbrokeneck** · 03-13-2011, 09:01 PM

"the delt is denser and therefore the release is slower which in turn extends the 1/2 life"

**bombboogie** · 03-13-2011, 09:06 PM

density is base on mass, is it not?

if so, would the buttocks be more dense?

doubt there is any truth in that.

**TGB1987** · 03-13-2011, 10:24 PM

Never heard of this. Can you post a source of this information? Where did you hear this from?

**Built** · 03-13-2011, 10:40 PM

Halflife is affected by the concentration, volume, and type of oil vehicle as well as injection site chosen.

Pharmacokinetics and pharmacodynamics of nandrolon... [J Pharmacol Exp Ther. 1997] - PubMed result

J Pharmacol Exp Ther. 1997 Apr;281(1):93-102.
Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and injection volume.

Minto CF, Howe C, Wishart S, Conway AJ, Handelsman DJ.

Department of Anaesthesia and Pain Management, Royal North Shore Hospital, University of Sydney, Australia.
Abstract

We studied healthy men who underwent blood sampling for plasma nandrolone, testosterone and inhibin measurements before and for 32 days after a single i.m. injection of 100 mg of nandrolone ester in arachis oil. Twenty-three men were randomized into groups receiving nandrolone phenylpropionate (group 1, n = 7) or nandrolone decanoate (group 2, n = 6) injected into the gluteal muscle in 4 ml of arachis oil vehicle or nandrolone decanoate in 1 ml of arachis oil vehicle injected into either the gluteal (group 3, n = 5) or deltoid (group 4, n = 5) muscles. Plasma nandrolone, testosterone and inhibin concentrations were analyzed by a mixed-effects indirect response model. Plasma nandrolone concentrations were influenced (P < .001) by different esters and injection sites, with higher and earlier peaks with the phenylpropionate ester, compared with the decanoate ester. After nandrolone decanoate injection, the highest bioavailability and peak nandrolone levels were observed with the 1-ml gluteal injection. Plasma testosterone concentrations were also influenced (P < .001) by the ester and injection site, with the most rapid, but briefest, suppression being due to the phenylpropionate ester, whereas the most sustained suppression was achieved with the 1-ml gluteal injection. Plasma inhibin concentrations were also significantly influenced by injection volume and site, with the lowest nadir occurring after the nandrolone decanoate 1-ml gluteal injection. Thus, the bioavailability and physiological effects of a nandrolone ester in an oil vehicle are greatest when the ester is injected in a small (1 ml vs. 4 ml) volume and into the gluteal vs. deltoid muscle. We conclude that the side-chain ester and the injection site and volume influence the pharmacokinetics and pharmacodynamics of nandrolone esters in an oil vehicle in men.

This is the full study: Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume

If you look at TABLE 4 Pharmacokinetic variables, you'll see a comparison of three different deca shots, plus an npp shot. Ignore the npp for now. The same dose of nandrolone decanoate in oil was administered under three paradigms: 4ml oil shot to glute, 1ml oil shot to glute, 1ml oil shot to delt. Time to peak was highest for the more concentrated 1ml glute shot (2.4 days), then for the (concentrated) 1ml delt shot (3.6 days) and lowest for the less concentrated 4ml glute shot (5 days)- in other words, in the delt, the halflife is longer for the same volume, concentration and dose nandrolone decanoate preparation.

**TGB1987** · 03-13-2011, 10:52 PM

Thank you Built. Learn something new everyday.

**Built** · 03-13-2011, 11:01 PM

At your service. I'll add that bioavailability is highest with a high-concentration glute-shot. The authors speculate higher blood flow and lower intramuscular fat in the deltoid may be factors which contribute to this effect.