Thread: Nolva: effect on IGF-1 and issues with 19-nor's

Can i first point out that we must be very careful with links like this and peoples opinions based on peer reviewed studies because they can not only be interpreted the wrong way they can also make giant leaps that that are totally unfounded.
Lets take your link as an example.
It says "Another popular explanation of the weakening action of Nolvadex is provided by studies which have shown that it reduced the plasma level of IGF-1".
Now i have studied andrology, oncology and endocrinology for many years and the only example of tamoxifen decreasing IGF-1 is in breast cancer cells, somehow the author and everyone else on the net has construed that therefore it's bad for us. Well, thats not necessarily the case because there are studies that show tamoxifen increases IGF-1 in brain cells in primates so to make such a general analogy is irresponsible and rather naive.
This unfortunately happens all to often as is the case with tamoxifens upregulation of Pgr, someone made a giant leap here again and it's now parroted on forums that you should not take tamoxifen when using 19nors, there no evidence to support this for our purposes as the only studies show an increase in Pgr in uterine cells.
I hope you can see what i'm getting at here.
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This was posted by a MOD on another forum I visit.

It's exam season here, so I really don't have the time to research the claims he has made.

What are your thoughts on this?

Thanks TGB, that was very informative once I got my head around it.

To what extent does the fact that cancer patient were used for the study affect the validity of the results, specifically how it relates to healthy individuals?