Thread: What is permanent with AAS?

Not Really sure where you would find that information.

1 Thing i do know is you will have Permanently damaged your HTPA system.

Enlarged Heart

Would that not be from HGH ?

Heart is a muscle so as you continue exercising and using AAS your heart will slowly get bigger.

I see.

Originally Posted by Imosted

Heart is a muscle so as you continue exercising and using AAS your heart will slowly get bigger.

There are actually different types of hypertrophy of cardiac muscle. Hypertrophy that comes from exercise does not inhibit function, but hypertrophy from having to pump against excessive pressure (i.e. blood pressure), will inhibit function.

The heart is the only muscle that keeps its enlarged size, unlike the rest of our muscles, which will eventually go back to normal size?

Hairloss, acne scars and liver damage.

Originally Posted by blazeftp

Not Really sure where you would find that information.

1 Thing i do know is you will have Permanently damaged your HTPA system.

Is this true even with short cycle duration and proper PCT with down time? I also wanted to hear some positives as well, if there are any.

Originally Posted by SFW

Hairloss, acne scars and liver damage.

Yup

Originally Posted by blazeftp

Not Really sure where you would find that information.

1 Thing i do know is you will have Permanently damaged your HTPA system.

I think "damaged" is a strong word. lol. Its not like all guys are doomed after a few cycles. Factors like cycle dosage and length will greatly determine your bodies own ability to recover. Most steroids were originally designed for medicinal purposes. It's the sports culture that upped the dosages to extremes. Most guys on here are smart and when they cycle off for good they will keep a good percentage of their gains and still look built until good old father time steals their bodies forever.

And most side effects of roid use is reversible with other gear and drugs.
Perms are:
-Liver
-Enlarged Prostate
-Balding ( faster rate)
-scars/stretch marks
-Metabolism Issues (Thyroid)
-Htpa inconsistencies with blood levels
-SPider Veins

Idk. theres more but thats just off hand.

Anabolic Steroids Still Provide A Competitive Edge In Power Lifting Even Years After Doping Has Ended

HILTON HEAD, SC—Anabolic steroids are synthetic hormones derived from the human male hormone testosterone. The use of steroids has been suspected in professional baseball and other sports where building muscle strength, rather than endurance, is paramount. Power lifting is such a sport. A team of researchers has examined the impact of anabolic steroid use on power lifters years after the athletes had ceased to take the drugs. The researchers found that while physical traces of the drug no longer remained, changes in the shoulder and quadriceps still gave lifters an advantage years later.

The research was conducted by Anders Eriksson and Lars-Eric Thornell, Department of Integrative Medical Biology, Section conducted the study for Anatomy, Umea University, Umea, Sweden; Christer Malm, Umeå University and Winternet and Patrik Bonnerud, Department of Health Science, Section for Medical Science, Lulea University of Technology, Lulea, Sweden; and Fawzi Kadi, Department of Physical Education and Health, Orebro University, Orebro, Sweden.
Dr. Eriksson will discuss the team’s study, “Anabolic Steroids Withdrawal in Strength Trained Athletes: How Does It Affect Skeletal Muscles?,” at a conference sponsored by the American Physiological Society (APS; www.The-APS.org). The conference, The Integrative Biology of Exercise V, will be heldSeptember 24-27, 2008 in Hilton Head, SC.

Background
Power lifting is a strength sport, requiring the use of a heavy dumbbell to perform three repetitions each of a squat, a bench press and a dead lift. It is in some ways similar to weight lifting, but where weightlifting is a dynamic sport, power lifting is a static one.
Power lifters focus on body strength, which relies heavily on muscle. The body’s main muscle fiber types: type I, type IIA and type IIB. Type I is the weakest and slowest, but has the most endurance. Type IIA is the strongest and fastest, but has the least endurance. Human muscles occur along a continuum of fiber types. For power lifters, type IIB fiber, the most powerful, is most frequently used. The use of anabolic steroids can add more nuclei to the muscle, and enhance muscle fiber size.
The researchers examined data in two muscles: the vastus lateralis, found in the quadriceps, and the trapezius, a part of the shoulder-neck muscle. Each muscle is key to power lifting.
Three groups were examined. One group was comprised of seven power lifters who had previously used anabolic steroids for long periods of time but stopped their usage some years ago (PREV). One group was currently power lifting but did not use steroids (P). The third group was power lifting and taking steroids (PAS). The researchers examined muscle fiber distribution, fiber area, subsarcolemmal and internal myonuclei number per fiber, myonuclei expressing androgen receptors, satellite cell numbers per fiber, and proportion of split fibers in each muscle for each individual.

Findings
The researchers found that several years after anabolic steroid withdrawal, and with no or low current strength-training, the muscle fiber area intensity, the number of nuclei per fiber in the quadriceps was still comparable to that of athletes that were currently performing high intensity strength-training. They also discovered that the shoulder-neck fiber areas were comparable to high-intensity trained athletes and the number of nuclei per fiber was even higher than found in the current steroid-using group.

Conclusions
According to the lead researcher, Dr. Eriksson, ”It is possible that the high number of nuclei we found in the muscle might be beneficial for an athlete who continues or resumes strength training because increased myonuclei opens up the possibility of increasing protein synthesis, which can lead to muscle mass.” He added, “Based on the characteristics between doped and non-doped power lifters, we conclude that a period of anabolic steroid usage is an advantage for a power lifter in competition, even several years after they stop taking a doping drug.”

https://dcprinciples.org/press/journal/08/29.htm

Great post, that's exactly what I was looking for. Is there anything else on myonuclei besides protein synthesis? I'm sure I can check google for that, but maybe there is more pertaining specifically to AAS.

Is there anything else thats positive besides an increased nuclei per fiber count after AAS use has stopped?

you can never claim to be natty ever again without lying...

lol holy shit that pic is great

Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men

Indrani Sinha-Hikim,1 Stephen M. Roth,2 Martin I. Lee,1 and Shalender Bhasin1

1Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059; and 2Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvamia 15261
Submitted 22 August 2002 ; accepted in final form 26 March 2003

ABSTRACT


Testosterone (T) supplementation in men induces muscle fiber hypertrophy. We hypothesized that T-induced increase in muscle fiber size is associated with a dose-dependent increase in satellite cell number. We quantitated satellite cell and myonuclear number by using direct counting and spatial orientation methods in biopsies of vastus lateralis obtained at baseline and after 20 wk of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of T enanthate. T administration was associated with a significant increase in myonuclear number in men receiving 300- and 600-mg doses. The posttreatment percent satellite cell number, obtained by direct counting, differed significantly among the three groups (ANCOVA P < 0.000001); the mean posttreatment values (5.0 and 15.0%) in men treated with 300- and 600-mg doses were greater than baseline (2.5 and 2.5%, respectively, P < 0.05 vs. baseline). The absolute satellite cell number measured by spatial orientation at 20 wk (1.5 and 4.0/mm) was significantly greater than baseline (0.3 and 0.6/mm) in men receiving the 300- and 600-mg doses (P < 0.05). The change in percent satellite cell number correlated with changes in total (r = 0.548) and free T concentrations (r = 0.468). Satellite cell and mitochondrial areas were significantly higher and the nuclear-to-cytoplasmic ratio lower after treatment with 300- and 600-mg doses. We conclude that T-induced muscle fiber hypertrophy is associated with an increase in satellite cell number, a proportionate increase in myonuclear number, and changes in satellite cell ultrastructure.

Strangely enough, I have maintained the hardness/muscle density promoted by Halotestin years ago. Even while off gear for a few years, I had certain indicators that my muscles had undergone a transformation. Thanks to Halotestin, my biceps, for example, have become (and stayed) more voluminous. Some strength gains in certain exercises were kept although these gains could have just as well been from natty lifting as well as gear induced lifting. I'd have to say the Halo left its permanent mark more so than any other gear.

Mindset changes also. Hard to ever take a long period of time off and lift natty again. You'll always think back to when you could lift a house and were as big as one.

Originally Posted by heavyiron

Anabolic Steroids Still Provide A Competitive Edge In Power Lifting Even Years After Doping Has Ended

HILTON HEAD, SC—Anabolic steroids are synthetic hormones derived from the human male hormone testosterone. The use of steroids has been suspected in professional baseball and other sports where building muscle strength, rather than endurance, is paramount. Power lifting is such a sport. A team of researchers has examined the impact of anabolic steroid use on power lifters years after the athletes had ceased to take the drugs. The researchers found that while physical traces of the drug no longer remained, changes in the shoulder and quadriceps still gave lifters an advantage years later.

The research was conducted by Anders Eriksson and Lars-Eric Thornell, Department of Integrative Medical Biology, Section conducted the study for Anatomy, Umea University, Umea, Sweden; Christer Malm, Umeå University and Winternet and Patrik Bonnerud, Department of Health Science, Section for Medical Science, Lulea University of Technology, Lulea, Sweden; and Fawzi Kadi, Department of Physical Education and Health, Orebro University, Orebro, Sweden.
Dr. Eriksson will discuss the team’s study, “Anabolic Steroids Withdrawal in Strength Trained Athletes: How Does It Affect Skeletal Muscles?,” at a conference sponsored by the American Physiological Society (APS; www.The-APS.org). The conference, The Integrative Biology of Exercise V, will be heldSeptember 24-27, 2008 in Hilton Head, SC.

Background
Power lifting is a strength sport, requiring the use of a heavy dumbbell to perform three repetitions each of a squat, a bench press and a dead lift. It is in some ways similar to weight lifting, but where weightlifting is a dynamic sport, power lifting is a static one.
Power lifters focus on body strength, which relies heavily on muscle. The body’s main muscle fiber types: type I, type IIA and type IIB. Type I is the weakest and slowest, but has the most endurance. Type IIA is the strongest and fastest, but has the least endurance. Human muscles occur along a continuum of fiber types. For power lifters, type IIB fiber, the most powerful, is most frequently used. The use of anabolic steroids can add more nuclei to the muscle, and enhance muscle fiber size.
The researchers examined data in two muscles: the vastus lateralis, found in the quadriceps, and the trapezius, a part of the shoulder-neck muscle. Each muscle is key to power lifting.
Three groups were examined. One group was comprised of seven power lifters who had previously used anabolic steroids for long periods of time but stopped their usage some years ago (PREV). One group was currently power lifting but did not use steroids (P). The third group was power lifting and taking steroids (PAS). The researchers examined muscle fiber distribution, fiber area, subsarcolemmal and internal myonuclei number per fiber, myonuclei expressing androgen receptors, satellite cell numbers per fiber, and proportion of split fibers in each muscle for each individual.

Findings
The researchers found that several years after anabolic steroid withdrawal, and with no or low current strength-training, the muscle fiber area intensity, the number of nuclei per fiber in the quadriceps was still comparable to that of athletes that were currently performing high intensity strength-training. They also discovered that the shoulder-neck fiber areas were comparable to high-intensity trained athletes and the number of nuclei per fiber was even higher than found in the current steroid-using group.

Conclusions
According to the lead researcher, Dr. Eriksson, ”It is possible that the high number of nuclei we found in the muscle might be beneficial for an athlete who continues or resumes strength training because increased myonuclei opens up the possibility of increasing protein synthesis, which can lead to muscle mass.” He added, “Based on the characteristics between doped and non-doped power lifters, we conclude that a period of anabolic steroid usage is an advantage for a power lifter in competition, even several years after they stop taking a doping drug.”

https://dcprinciples.org/press/journal/08/29.htm

I read this same thing in Anabolics. Im wondering whats hyperplasia like from HGH ?