Thread: Mix OSTA & clomid & aromasin in grapefruit juice OK?

It will not reduce potentcy but could slow down rate of metabolism of drug. Grapefruit juice inhibits an enzyme in the liver which reduces livers ability to process certain drugs.

If anything I'd think it would slow the metabolism, which may be a good or bad thing. Sarm's are somewhat suppressive so it could cause it to be moreso, or it could provide better gains.

I'm not even sure if they interact with that particular enzyme, so it may do nothing, really I think you might be better off avoiding it just to be safe.

i didnt get the idea by myself. i had seen someone already do it.

however i was under the impression that Grapefruit juice, increases absorption.

in my younger days people used to drink thier rolls with grapefruit juice for it to hit better.

and instead of dwoning the liquid in my mouth and then washing it out with grapefruit juice, i thought it would be the same and easier to put all three in the shot glass with the juice and take the shot.

i dont know about you guys, but OSTA is probably the worst thing i have ever tasted and it last for quite a while. that sh!t tastes NASTY!!!

lol...

thanks for the input guys

I'm not sure it increases absorption, but it inhibits the CYP3A4 enzyme. This enzyme breaks down a number of different drugs (benzos and opiates for sure, quite a few others that I don't remember off the top of my head). Here's some info I found, I couldn't find any studies on Osta but s4 is another SARM so I'm guessing they are metabolized similarly. Same with clomid, the study I found determined another enzyme is primarily responsible for it's metabolism but that cyp3a4 plays a role as well.

"In vitro evidence showed that exemestane is metabolised through cytochrome P-450 (CYP) 3A4 and aldoketoreductases and does not inhibit any of the major CYP isoenzymes. In a clinical pharmacokinetic study, the specific inhibition of CYP3A4 by ketoconazole showed no significant effects on the pharmacokinetics of exemestane.
Although administration of rifampicin, a potent CYP3A4 inducer, significantly decreased exemestane systemic exposure (Cmax and AUC), the suppression of plasma estrogen levels (estrone sulfate) produced by exemestane was not influenced. Therefore, exemestane can be given concomitantly with inducers of CYP3A4 without dosage adjustment."

"Tamoxifen is structurally related to clomiphene, and also shows considerable variation in response. CYP2D6 and CYP3A4 are major contributors to the metabolism of tamoxifen" (not clomid, but they're structurally similar enough I think you should keep it in mind


"Among the five enzymes tested, CYP3A4 was identified as one of the major P450 enzymes that might be responsible for S4 metabolism"


Soo grapefruit is most likely going to inhibit the metabolism of all three drugs in that cocktail to some degree. The aromasin study specifically says the estrogen lowering effects aren't changed but I couldn't find the same on the others. Honestly I think you'd be better off removing the grapefruit from the equation since there really isn't enough to go on here. Unless you're seriously strapped for cash the moderate increase you MIGHT see isn't worth the possible side effects IMO.

Also I'm not sure you're aware because so many sites seem to say that SARM's aren't suppressive but I've seen a number of cases that say otherwise. If you like I'll link you to a thread where a guy got bloodwork before and after cycle, he was using S4 instead of Osta, but his test levels were half what they were to begin with. I would love for them not to be suppressive at all as I'd run them myself during pct. But from everything I've read you run the risk of not fully recovering while using a Sarm. Sry for the long post but hopefully it helps you :P

Originally Posted by Digitalash

I'm not sure it increases absorption, but it inhibits the CYP3A4 enzyme. This enzyme breaks down a number of different drugs (benzos and opiates for sure, quite a few others that I don't remember off the top of my head). Here's some info I found, I couldn't find any studies on Osta but s4 is another SARM so I'm guessing they are metabolized similarly. Same with clomid, the study I found determined another enzyme is primarily responsible for it's metabolism but that cyp3a4 plays a role as well.

"In vitro evidence showed that exemestane is metabolised through cytochrome P-450 (CYP) 3A4 and aldoketoreductases and does not inhibit any of the major CYP isoenzymes. In a clinical pharmacokinetic study, the specific inhibition of CYP3A4 by ketoconazole showed no significant effects on the pharmacokinetics of exemestane.
Although administration of rifampicin, a potent CYP3A4 inducer, significantly decreased exemestane systemic exposure (Cmax and AUC), the suppression of plasma estrogen levels (estrone sulfate) produced by exemestane was not influenced. Therefore, exemestane can be given concomitantly with inducers of CYP3A4 without dosage adjustment."

"Tamoxifen is structurally related to clomiphene, and also shows considerable variation in response. CYP2D6 and CYP3A4 are major contributors to the metabolism of tamoxifen" (not clomid, but they're structurally similar enough I think you should keep it in mind


"Among the five enzymes tested, CYP3A4 was identified as one of the major P450 enzymes that might be responsible for S4 metabolism"


Soo grapefruit is most likely going to inhibit the metabolism of all three drugs in that cocktail to some degree. The aromasin study specifically says the estrogen lowering effects aren't changed but I couldn't find the same on the others. Honestly I think you'd be better off removing the grapefruit from the equation since there really isn't enough to go on here. Unless you're seriously strapped for cash the moderate increase you MIGHT see isn't worth the possible side effects IMO.

Also I'm not sure you're aware because so many sites seem to say that SARM's aren't suppressive but I've seen a number of cases that say otherwise. If you like I'll link you to a thread where a guy got bloodwork before and after cycle, he was using S4 instead of Osta, but his test levels were half what they were to begin with. I would love for them not to be suppressive at all as I'd run them myself during pct. But from everything I've read you run the risk of not fully recovering while using a Sarm. Sry for the long post but hopefully it helps you :P

no need to apologize man you really helped me alot. i will remove the grapefruit, and i think i am going to start putting the osta liquid in a fish oil capsule, because i really cant stand the taste. that's really the only reason for doing that.

would i be able to put it in any other liquid that can at least kinda mask the taste? if not can i mix them in shot glass filled with water and will that cause any degradation or lost in potency? thats so i can atleast put all three in something and not have to taste it as much.

or i might just wash my mouth with like li sterine after. i am strapped for cash so looking for the most effective cheapest method...


man thanks for all your help again.