I've heard smoking weed and juicing can generate a disposition for gyno because of the increased estrogen, and I don't know how true it is. Plus, I also heard that it can stop test production...but being on artificial production of test, that might not be the same.
Kind of convoluted.
However, for increased appetite during a bulk, it might be useful.
Anyone want to chime in? I'm not a pothead, just interested in the answer.
I did find this however:
Marijuana extracts possess the effects like the endocrine disrupting chemicals
Kazuhito Watanabea, , , Erina Motoyaa, Naoki Matsuzawaa, Tatsuya Funahashia, Toshiyuki Kimuraa, Tamihide Matsunagab, Koji Arizonoc and Ikuo Yamamotod
aDepartment of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan
bDivision of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto 390-8621, Japan
cLaboratory of Toxicological Science, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Kumamoto 862-8502, Japan
dSchool of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan
Received 21 July 2004; revised 1 August 2004; accepted 11 August 2004. Available online 16 September 2004.
Abstract
The progesterone 17α-hydroxylase activity, which is one of the steroidogenic enzymes in rat testis microsomes, was significantly inhibited by crude marijuana extracts from Δ9-tetrahydrocannabinolic acid (THCA)- and cannabidiolic acid (CBDA)-strains. Δ9-Tetrahydrocannabinol, cannabidiol and cannabinol also inhibited the enzymatic activitiy with relatively higher concentration (100–1000 μM). Testosterone 6β- and 16α-hydroxylase activities together with androstenedione formation from testosterone in rat liver microsomes were also significantly inhibited by the crude marijuana extracts and the cannabinoids. Crude marijuana extracts (1 and 10 μg/ml) of THCA strain stimulated the proliferation of MCF-7 cells, although the purified cannabinoids (THC, CBD and CBN) did not show significant effects, such as the extract at the concentration of 0.01–1000 nM. These results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana.
Keywords: Marijuana; Endocrine disrupting chemicals; Testosterone; Estrogen; MCF-7




Reply With Quote








