Single deca injection causes genetic damage in animal test

**Prince** · 08-20-2011, 01:46 PM

Single deca injection causes genetic damage in animal test

Since the arrival of effective anti-oestrogens like anastrazole and tamoxifen, chemical athletes have taken to using testosterone instead of nandrolone decanoate – the active ingredient in Deca-Durabolin. Testosterone is considerably safer than nandrolone, especially at higher doses, chemical athletes have noticed.

A soon-to-be-published animal study has proved them correct. According to the research, the results of which will be published in the Journal of Applied Toxicology, nandrolone damages genetic material.

Hundreds of thousands of people use nandrolone, but we still don't know an awful lot about this anabolic steroid. In the fifties and sixties, when nandrolones first appeared on the market, pharmaceutical companies didn't do as much research on the side effects of their medicines as they do now.

Brazilian researchers at the Universidade Estadual Paulista wanted to know whether nandrolone causes damage to genes. Estradiol, a steroid that bears similarities to nandrolone, does do this. So, the Brazilians' reasoned, nandrolone decanoate may do the same.

The Brazilians injected male mice once with Deca-Durabolin. The mice got 1, 2.5 or 5 mg per kg bodyweight of nandrolone decanoate. One control group was given a groundnut oil injection, another got doxorubicin, a substance that is toxic to cells and is used in chemotherapy.

The entire experiment consisted of a single injection. After that the researchers took cell samples from the mice and examined the amount of damage to the DNA.

The results of the Comet Assay are shown below. A Comet Assay is a way of 'decombining' DNA using electric fields. The easier this is, the worse DNA is damaged. The higher the score, the greater the damage.

Another test the Brazilians used was the Micronucleus Test, the results of which are shown above. The Micronucleus Test involves counting 'wrong' nuclei in cells [MNCPE]. Cells exposed to genotoxic substances sometimes make an extra nucleus when they divide. The more extra cell nuclei the researchers see, the greater the genotoxic effect of the substance.

Cells can repair genetic damage. If they don't manage to do this, cells can self-destruct or immune cells clear up the deviant cells. But sometimes, if none of these mechanisms work, a damaged cell will turn into a cancer cell. Whether this can also happen if you use nandrolone decanoate, the Brazilians don't know. 'Carcinogenic' is a couple of steps further than 'genotoxic'. With this 'caveat' in mind, the researchers advise caution.

"Since a number of different types of mutations are involved in cancer etiology or other genetic diseases, we recommend great caution in the acute or chronic administration of nandrolone", they write. "Careful consideration of the risks vs benefits needs to be carried out before it is used in the human population."

Source:
J Appl Toxicol. 2011 Jun 30. doi: 10.1002/jat.1701. [Epub ahead of print].

**TGB1987** · 08-20-2011, 03:44 PM

Wow of course I would be in the middle of a Test and Deca cycle when this comes out.

**Mooksman** · 08-20-2011, 04:19 PM

Originally Posted by TGB1987

Wow of course I would be in the middle of a Test and Deca cycle when this comes out.

Lol. That sucks. Lol.

**alphabolic** · 08-20-2011, 04:44 PM

better deca than tren...i have no interest in nandrolone

**MrSaturatedFat** · 08-20-2011, 04:59 PM

Originally Posted by TGB1987

Wow of course I would be in the middle of a Test and Deca cycle when this comes out.

Shit me too bro!

are we gonna dies?

**Vibrant** · 08-20-2011, 05:01 PM

Originally Posted by TGB1987

Wow of course I would be in the middle of a Test and Deca cycle when this comes out.

Ouch, that hurts. Lol, kidding. It doesn't necessarily mean that nandrolone acts the same way in humans as it does in mice....

**Prince** · 08-20-2011, 05:26 PM

when I am using very high levels I have found that adding deca helps my joints, but when I am just cruising like I am now no deca is needed for me.

**pieguy** · 08-20-2011, 06:43 PM

Err, should we be shying away from NPP and Deca from now on

? All aboard the tren train?

**Prize** · 08-20-2011, 06:57 PM

Damn...I thought I had my next cycle all figured out. I guess I'll have to go back to the drawing board and take another look at masteron, winny and EQ. Maybe I should just slam the test alone??

**jackedntan** · 08-20-2011, 07:49 PM

I wonder if all 19-nor steroids have this effect? Hopefully its just limited to deca. I dnt thnk there's been any documented cases of deca causing cancer, has there?

**Digitalash** · 08-20-2011, 08:11 PM

There was another study showing deca decreased the growth of blood vessels at a much lower dosage than test. Not sure exactly what effect that would have but I imagine interfering with your blood vessel's ability to repair themselves is not a good thing. Now it's genotoxic as well? If I didn't already have joint issues I'd probably be staying away from nandrolone...

**Mike225** · 08-21-2011, 10:04 AM

Tried deca once and never again its not worth it

**GMO** · 08-21-2011, 02:41 PM

Nandrolone is a lean mass powerhouse, and some obscure Brazilian study done on rats is not going to dissuade me in the least. Although, I will probably never use deca again, b/c the short ester NPP is much easier to recover from. But that's just me...

**TGB1987** · 08-21-2011, 05:26 PM

I am going to continue to with the Deca until it is official but I agree with GMO NPP is much easier to recover from. I started with NPP then transitioned to Deca. NPP will probably be my choice for future use as well just faster and more for your money.

**Pittsburgh63** · 08-21-2011, 05:29 PM

I'm still gonna hit 600mg of deca ew on my next cycle. Fuck it.

**Digitalash** · 08-21-2011, 07:49 PM

lmao I agree, we all know what we're doing isn't 100% safe. I'm not really convinced this is as bad as it sounds anyway so I'll def use npp or deca again in the future.

**Pav636** · 08-23-2011, 09:02 AM

hmm have ran test, deca and d-bol without any issues....Was going to be my next cycle not I dont know which way I should go...

**squigader** · 08-23-2011, 10:13 AM

Ouch... that and the metabolites stay in your system for 18 months. Guess I'm ruling out deca.

**S_walker** · 08-23-2011, 10:29 AM

damn I was thinking of bumping my deca from 200mg to 400mg. i think i'll just keep it low at 200mg. i hate reading this kinda shit now that i'm just starting to notice the deca with my joint issues. __________sigh

**malfeasance** · 08-23-2011, 01:01 PM

Does anybody know if this same experiment has been performed on other steroids? What if it is the same with all of them?

**pieguy** · 08-23-2011, 05:28 PM

No idea on other steroids but its been performed on humans with he same result

**Livebig14** · 08-23-2011, 05:32 PM

Originally Posted by pieguy

No idea on other steroids but its been performed on humans with he same result

Post the studies please I would like to read them

**ZECH** · 08-23-2011, 07:51 PM

Eh, it's just one study. Still a good choice for mass building IMO. There's risk with everything.

**Digitalash** · 08-23-2011, 09:03 PM

Maybe you'll get lucky and the genetic mutation will turn you into the Hulk

**pieguy** · 08-23-2011, 11:34 PM

Originally Posted by Livebig14

Post the studies please I would like to read them

It's in the elite forum. I don't wanna get killed by Prince

**malfeasance** · 08-24-2011, 03:37 PM

Originally Posted by pieguy

No idea on other steroids

That's my point! No sense in looking for substitutes to Nandrolone without knowing whether the substitutes all do the same thing or maybe even worse!

**SloppyJ** · 08-24-2011, 04:05 PM

I'm with GMO on this one. Fuck it. I'm still gonna run NPP. Do a test on humans and we can talk.

**pieguy** · 08-24-2011, 04:59 PM

Originally Posted by SloppyJ

I'm with GMO on this one. Fuck it. I'm still gonna run NPP. Do a test on humans and we can talk.

They did sloppyj, same result. Damage to DNA of deca users.

**GMO** · 08-24-2011, 05:56 PM

Originally Posted by pieguy

They did sloppyj, same result. Damage to DNA of deca users.

Study? Where? Post that shit up...

**Imosted** · 08-24-2011, 06:05 PM

Dont be jews, become elite and read lol

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