Thread: Trenbolone, a practical application~Updated

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E650-60. Epub 2011 Jan 25.

17{beta}-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate.

Yarrow JF, Conover CF, McCoy SC, Lipinska JA, Santillana CA, Hance JM, Cannady DF, Vanpelt TD, Sanchez J, Conrad BP, Pingel JE, Wronski TJ, Borst SE.

VA Medical Center, Research - 151, 1601 SW Archer Rd., Gainesville, FL 32608-1197. jfyarrow@ufl.edu.

Abstract

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the hypothesis that trenbolone-enanthate (TREN) might prevent orchiectomy-induced losses in muscle and bone and visceral fat accumulation without increasing prostate mass or resulting in adverse hemoglobin elevations. Male F344 rats aged 3 mo underwent orchiectomy or remained intact and were administered graded doses of TREN, supraphysiological testosterone-enanthate, or vehicle for 29 days. In both intact and orchiectomized animals, all TREN doses and supraphysiological testosterone-enanthate augmented androgen-sensitive levator ani/bulbocavernosus muscle mass by 35-40% above shams (P ≤ 0.001) and produced a dose-dependent partial protection against orchiectomy-induced total and trabecular bone mineral density losses (P < 0.05) and visceral fat accumulation (P < 0.05). The lowest doses of TREN successfully maintained prostate mass and hemoglobin concentrations at sham levels in both intact and orchiectomized animals, whereas supraphysiological testosterone-enanthate and high-dose TREN elevated prostate mass by 84 and 68%, respectively (P < 0.01). In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.

PMID: 21266670 [PubMed - in process]

nice heavy

great write up

That is a good read.

I also have a love hate relationship with tren.

Even at 350mg/week I have a really hard time sleeping and just a general fluish feeling.

Although I have never used anything that gets me as lean as quickly as tren.

I think the androgen replacement with tren is really interesting. Has anybody here tried it?

I could imagine that 50-100mg/week would probably be enough to get some positive benefit from long term use.

(I'm always interested in non-traditional hrt though)

250mg if test and 200mg tren e was wonderful! Almost no sides and sweet ass gains. Great cruise. Will be doing it again.

Sent from my Samsung Infuse 4G

it says to run 2x as much test as tren. right now im running test/tren/mast each at 350mg a week. is it ok if i keep the test at 350 or does it really need to be increased?

This is great thread.

some of Trenabolic AP gear pic...no fina breathing problem happen with AP!

Originally Posted by keith1569

250mg if test and 200mg tren e was wonderful! Almost no sides and sweet ass gains. Great cruise. Will be doing it again.

Sent from my Samsung Infuse 4G

What sides or how bad was your experience with 200mg of tren e a week?

Originally Posted by maxwkw

I also have a love hate relationship with tren.

Even at 350mg/week I have a really hard time sleeping and just a general fluish feeling.

Although I have never used anything that gets me as lean as quickly as tren.

I think the androgen replacement with tren is really interesting. Has anybody here tried it?

I could imagine that 50-100mg/week would probably be enough to get some positive benefit from long term use.

(I'm always interested in non-traditional hrt though)

Yes, the information is very preliminary but quite interesting on the concept of using Trenbolone as an androgen replacement. I imagine a low Test and low Tren dose would be ideal rather than Trenbolone by itself though.

Originally Posted by alphabolic

it says to run 2x as much test as tren. right now im running test/tren/mast each at 350mg a week. is it ok if i keep the test at 350 or does it really need to be increased?

Your doses are absolutely fine. I was just writing about my personal preferences when using Trenbolone brother.

hey heavy next time i do a cycle want to try test,tren havoc cycle....what do you think and how would you do it?

Originally Posted by alphabolic

it says to run 2x as much test as tren. right now im running test/tren/mast each at 350mg a week. is it ok if i keep the test at 350 or does it really need to be increased?

It is interesting to read this as in another thread there were some guys talking about running the tren almost double the test and seeing excellent results with the rational being you are saturating receptor with the more potent drug (tren instead of test). Correct me if I read that wrong guys, I think it was posted last week.

Originally Posted by KILLEROFSAINTS

hey heavy next time i do a cycle want to try test,tren havoc cycle....what do you think and how would you do it?

Its a decent stack but I would need to know more about your goals to advise.

Just tried tren for the first time. 50mg ED with 750 test E and 600 EQ threw it in around week 10 and it's fucking amazing.

Great write up and pictures heavy, I will have it featured on the Blog very soon! thank you for your time and effort with this piece!

Originally Posted by heavyiron

Its a decent stack but I would need to know more about your goals to advise.

if you dont know me by now....

Originally Posted by KILLEROFSAINTS

if you dont know me by now....

Do you have a goal date or length of cycle in mind? Is it a cut?

Originally Posted by heavyiron

Do you have a goal date or length of cycle in mind? Is it a cut?

i dont have anything in mind other than body fat decrease....whatever you suggest for length.....you said the cycle was decent how could it be better.....im not concerned with getting stronger anymore since my joints cant take it anyway....less fat.... look better....same old same old

Originally Posted by KILLEROFSAINTS

i dont have anything in mind other than body fat decrease....whatever you suggest for length.....you said the cycle was decent how could it be better.....im not concerned with getting stronger anymore since my joints cant take it anyway....less fat.... look better....same old same old

600mg Test weekly
300mg Tren weekly
Havoc as directed on the bottle the first part of the cycle

Respect for your work heavy keep up the good work

Its just sad another sponsor is using your thread to advertise his producst

hope too see some more of these posts from you we need them

Originally Posted by heavyiron

Trenbolone, a practical application by heavyiron

Trenbolone Acetate may be used for cutting, bulking or re-comping. This steroid is very versatile. But out of the three, Trenbolone seems best suited for re-comping. Body re-composition is when you lose body fat and gain muscle mass. It’s not just cutting fat but cutting fat AND adding muscle. If you have been bodybuilding for any period of time you understand how difficult this can be. In fact, re-comping becomes harder and harder the longer you body build. Eventually you hit a wall. This is when we may add Trenbolone to keep gains rolling.

History

Trenbolone is available in a variety of esters that prolong the release time of this hormone. In 1967 Trenbolone was well studied attached to the long acting undecanoate ester. This ester is similar in action to the French Parabolan brand, also called Hexabolan due to the hexahydrobenzylcarbonate ester. Parabolan was sold for human consumption by Negma Laboratories therefore Trenbolone was a legitimate medicine approved for human use at one time. Trenbolone Acetate was the ester of choice used in the early 1970’s in veterinary medicine. Trenbolone Acetate was marketed at this time in England under the brand name Finajet and as Finaject in France. Trenbolone acetate in the form of Finaplix pellets has been widely used all over the world to add weight and improve feed efficiency in cattle.

Cycling for men

Setting up a cycle with Trenbolone depends on many things such as goals, experience level, side effects experienced and threshold for risk. I personally have found that Trenbolone stacked in a specific dose with Testosterone and timed properly can illicit terrific results on a re-comp while minimizing side effects. The following are some sample cycles using Trenbolone Acetate on a re-comp.



*This cycle is for newer users of Trenbolone Acetate*

Week 1-8 500mg Testosterone C or E
Week 9-12 750mg Testosterone / 350mg Tren Ace
Week 13 350mg Tren Ace

Tren Ace (100mg eod) is added at week 9 just about the time gains begin to diminish in a standard cycle. This timing is critical to "push" gains so do not alter the timing. The Tren Ace is ran for a short but effective 5 weeks. This will give a first time user some experience with the compound to assess side effects. Running the Tren the 13th week will keep gains rolling while the Testosterone E or C ester is clearing. Testosterone Propionate may be run throughout as well.

*This cycle is for experienced users going into a 16 week prep*

Week 1-6 500mg Test E
Week 7 750mg TE
Week 8 1 gram TE
Week 9 1 gram TE / 350mg Tren Ace
Week 10 1,250mg TE / 350mg Tren Ace
Week 11 1,250mg TE / 350mg Tren Ace
Week 12 1,500mg TE / 350mg Tren Ace
Week 13 525mg Tren Ace / 525mg Test Prop
Week 14 525mg Tren Ace / 525mg Test Prop / 100mg Winstrol tabs daily
Week 15 525mg Tren Ace / 100mg Winstrol tabs daily
Week 16 100mg Winstrol tabs daily

Tren Ace (100mg eod) is added at week 9 just about the time gains begin to diminish in a standard cycle. This timing is critical to "push" gains so do not alter the timing. Notice the Tren and Test Prop extend 2 weeks past the higher dose of Testosterone. This is purposeful to keep gains rolling while the higher dose T Enanthate is clearing. Basically gains should continue through week 14 with this setup.

Ancillaries and post cycle therapy

Cabergoline will lower prolactin and using an aromatase inhibitor alongside it will control E2 from the Testosterone during the cycle. I personally prefer Pramipexole over Cabergoline since Pramipexole has the ability to raise GH and still works well to lower prolactin.

I would run HCG at least the last 3-4 weeks on cycle and while the meds are clearing. Clomid is a great recovery drug at 50-100mg daily for 4-6 weeks for PCT. Some guys need an AI after the Clomid but only labs can confirm this. If the individual is on hormone replacement therapy that therapy may be resumed immediately post cycle rather than using the above PCT.



Ladies and Trenbolone

Trenbolone is virilizing in women so extreme caution must be used when administering Trenbolone to females. Virilization in a woman can manifest as clitoral enlargement, increased muscle strength, acne, hirsutism, frontal hair thinning, deepening of the voice, and menstrual disruption. Depending on the female’s threshold for risk, 30mg of Trenbolone Acetate weekly is where I would advise a lady to start. (10mg mon, wed, fri.) More adventuresome females may take 90mg Tren Ace weekly but I would not advise that on a first run. I recommend an insulin syringe to get very accurate dosing and lower the risk of scar tissue.



Trenbolone for androgen replacement in men

In January 2011 Trenbolone Enanthate was studied as a possible alternative for Testosterone replacement therapy in the hopes that Trenbolone would not increase prostrate mass or cause adverse hemoglobin elevations and that it would prevent bone and muscle loss. The following is a direct quote from the abstract.

“In summary, low-dose administration of the non-5α-reducible androgen TREN maintains prostate mass and hemoglobin concentrations near the level of shams while producing potent myotrophic actions in skeletal muscle and partial protection against orchiectomy-induced bone loss and visceral fat accumulation. Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy.”



Trenbolone Acetate is a steroid I have had a love hate relationship with. I love Tren’s powerful positive effects but hate the equally powerful side effects. Over the years I have experimented with various methods of using Trenbolone to its full advantage but at the same time minimizing the side effects. The side effects that users report range from increased aggression, insomnia, profuse sweating, “Tren cough” and reduced libido as well as a host of other sides that are common with androgen's.

Trenbolone is quite powerful especially when used in certain ways. In fact, Trenbolone is 3-5 times more anabolic and androgenic than Testosterone. Trenbolone binds to androgen receptors (ARs) with approximately three times the affinity of testosterone and has been shown to augment skeletal muscle mass and bone growth and reduce adiposity! Tren is one potent weapon in the bodybuilder’s arsenal. Therefore, trying to figure out a way to maximize Trenbolones amazing potential while minimizing its side effects has been a pursuit of mine. Obviously, reducing the dosage is a way to reduce side effects since many times side effects are dose dependent. Some users report that small, every day injections reduce side effects and this can easily be done with an insulin syringe in a lean muscle group. Stacking with complimentary steroids such as Testosterone maximizes Trenbolones potential and also reduces side effects such as loss of libido. I'm convinced there's almost no other traditional injectable stack that's as potent and versatile as Testosterone and Trenbolone. It's a simple stack with enormous potential to harden muscle, promote fat loss and add raw strength. Since Trenbolone is so anabolic it's a great muscle builder as well. I prefer dosing Testosterone at least two times higher than the Trenbolone dose. First time users of Trenbolone may start as low as 200mg Tren weekly and see its effects. More adventuresome users may double that dosage to 400mg Tren weekly.

great information on the tren is that acetate or tren e

Thank for doing this Heavy. How quickly does it take for Tren Ace kick in???

Originally Posted by euroking

Respect for your work heavy keep up the good work

Its just sad another sponsor is using your thread to advertise his producst

hope too see some more of these posts from you we need them

EK you are right.

How to use Trenbolone Acetate by heavyiron

Originally Posted by rjd

Thank for doing this Heavy. How quickly does it take for Tren Ace kick in???

Blood androgen levels spike very rapidly with most injectable steroids so not sure what you mean.

I just made 40 mls of tren from finaplix its prolly a little under 100 mg.per ml. i did 1 ml in my delt only had a .22 ga. 3/4 in. pin. so thats what i used i was waiting for the mettalic tasting tren cough but nothing. Unusual? I noticed you had a 29 ga. 1/2 pin. Is that just for pecs, tris etc. or do you use that for delts too.? im not gonna hit myself 4 times a week with a .22 was gonna go with a .25 .can i use a .29 for delts?

As long as you're lean enough, yes.

Been slin pinning it for a few weeks in my delt. Works great

Originally Posted by delcapone

I just made 40 mls of tren from finaplix its prolly a little under 100 mg.per ml. i did 1 ml in my delt only had a .22 ga. 3/4 in. pin. so thats what i used i was waiting for the mettalic tasting tren cough but nothing. Unusual? I noticed you had a 29 ga. 1/2 pin. Is that just for pecs, tris etc. or do you use that for delts too.? im not gonna hit myself 4 times a week with a .22 was gonna go with a .25 .can i use a .29 for delts?

Yeah, I can hit delts, quads and pecs no problem with a 29g slin pin. Even if you are a bit fat just bury the pin and dimple in the site with the hub of the pin.