Thread: Does your body get used to gear?

Just run Test E and Tren E again. You can add dbol to kickstart the cycle.

I know guys who run only Test E for years and they are still growing.

Yeah man you're good with using the same compounds. saying you'll build up a tolerance or 'get used to' certain compounds is bullshit (clen or some others are a different story, but AAS youre all good)

nice one guys i thought as much i mean the guy i get my shit off told me that "my body will be used to it" but i thought no way ive been off for what feels like ages i cant wait to get back on the test e and tren e the stuff is great! as for dbol kick start i have tbol here ill just use that... thanks u guys just wanted to double check..

Originally Posted by ScottyMac710

Yeah man you're good with using the same compounds. saying you'll build up a tolerance or 'get used to' certain compounds is bullshit (clen or some others are a different story, but AAS youre all good)

Sorry, bro...but that is incorrect. AAS are drugs and all drugs have the ability to cause tolerance issues within your physiology. I know this by medical fact as well as personal experience. My first cycle ever was 300mg of test per week. Now I require at least 500-750mg to get noticeable results. In addition, d-bol, a compound I use regularly, I now require doses of 75mg+ for the same results I used to get from 20-30mg.

Drug tolerance is a very well known and studied phenomenon, and you can find plenty of data and studies regarding it online.

OP: You'll be fine with those compounds and if this is only a second cycle, you may not have to increase dosages. Overtime however as you continue to acquire more cycles under your belt, rest assured, you will be running higher dosages to yield the same results.

I was waiting for you to comment on this GMO. As always your a fuckin fountain of knowledge

^

yea I have to run gear at higher doses to get same results,and if I run cyp one cycle I run eth next to switch it up

Originally Posted by ontopthegame85

yea I have to run gear at higher doses to get same results,and if I run cyp one cycle I run eth next to switch it up

i been running enan for a long time, would the longer cyp ester really make that big a difference?

I ran very similar cycles for years and just kept gaining but my doses were pretty high to begin with =)

Originally Posted by GMO

Sorry, bro...but that is incorrect. AAS are drugs and all drugs have the ability to cause tolerance issues within your physiology. I know this by medical fact as well as personal experience. My first cycle ever was 300mg of test per week. Now I require at least 500-750mg to get noticeable results. In addition, d-bol, a compound I use regularly, I now require doses of 75mg+ for the same results I used to get from 20-30mg.

Drug tolerance is a very well known and studied phenomenon, and you can find plenty of data and studies regarding it online.

OP: You'll be fine with those compounds and if this is only a second cycle, you may not have to increase dosages. Overtime however as you continue to acquire more cycles under your belt, rest assured, you will be running higher dosages to yield the same results.

Very interesting to hear, I've seen studies and heard people say otherwise when dealing with androgens but am glad to hear this side of it. From what I remember reading I thought that androgen receptors were only desensitized with extreme doses and were able to return to normal sensitivity fairly easily. Other receptors I know become down-regulated and desensitized easily (opiates, amphetamines / beta receptors, etc.) but i was under the impression that androgen receptors did not act in the same way. Thanks for your post, I'll definitely take it into consideration knowing that now

here's a question, if running test for a while causes myostatin to increase/androgen receptors to downregulate, why does your natural test production continue to provide gains essentially your whole life?

Originally Posted by gymrat09091974

i been running enan for a long time, would the longer cyp ester really make that big a difference?

No. Ester will make close to no difference. It is the active ingredient that the body adapts to.

Originally Posted by Digitalash

here's a question, if running test for a while causes myostatin to increase/androgen receptors to downregulate, why does your natural test production continue to provide gains essentially your whole life?

Who says it does?

The body starts to deteriorate naturally past the age of 40 (referring to sarcopenia) .

But to answer your question it is all about tolerance levels and feedback loops. For most people they are relative the same but with just about anything there is a bellcurve that the population falls into.

Yeah I mean over a period of a few years where your natural production stays roughly the same, you don't become "insensitive" to your own test right? So why if you run a cycle do gains drop off so dramatically after a certain period of time. I'm not saying anyone's wrong I'm honestly trying to understand the situation or if I'm missing a crucial detail here.

Originally Posted by Digitalash

here's a question, if running test for a while causes myostatin to increase/androgen receptors to downregulate, why does your natural test production continue to provide gains essentially your whole life?

Read this.

http://www.afboard.com/library/Measu...nistration.pdf


Go to the bottom and read "Effects of Test. administration on myostatin levels in men."

Your myostatin levels only raise for a short period of time while on cycle (Around day 56) and then reutrn to base line. It's not like with each cycle your myostatin levels keep increasing on top of the previous level.

And your body does start to degrade at a certian age. That's how TRT came about.

That requires coming off though right? Myostatin won't return to normal on it's own after being on for a while will it? So does myostatin come into play where natural test is concerned? I'll read the link though thank you

Edit: ok I see what you're saying, so myostatin will return to baseline after a certain amount of time on? Also I've seen this in a number of studies, lbm increases with use of testosterone even without training? I know there are other things that factor into lean body mass but a good portion of that would be muscle?

Originally Posted by heavyiron

I ran very similar cycles for years and just kept gaining but my doses were pretty high to begin with =)

you mean my cycle yeah test e and tren e?

My last cycle was the first time running tren and can honestly say it was my best cycle yet loved it, only sides i got was cardio went to shit, and although i could sleep on it i would often wake up very easly the slightest noise in the house and id be up! and wouldnt be able to get back to sleep.. gonna up the dose very slighlty not to much..

Originally Posted by GMO

Sorry, bro...but that is incorrect. AAS are drugs and all drugs have the ability to cause tolerance issues within your physiology. I know this by medical fact as well as personal experience. My first cycle ever was 300mg of test per week. Now I require at least 500-750mg to get noticeable results. In addition, d-bol, a compound I use regularly, I now require doses of 75mg+ for the same results I used to get from 20-30mg.

Drug tolerance is a very well known and studied phenomenon, and you can find plenty of data and studies regarding it online.

OP: You'll be fine with those compounds and if this is only a second cycle, you may not have to increase dosages. Overtime however as you continue to acquire more cycles under your belt, rest assured, you will be running higher dosages to yield the same results.

yeah i know all about building up tolerences to drugs just wasnt sure if the same applyed to the gear..

yeah this is only my second time running tren e was gona run test e and drol but im gonna leave that till my next cycle i think..so i decided to go with the tren plus it was my best cycle i have done fucking loved it.. the thing is it was so good i dont want to come off now when i start my next cycle..

Originally Posted by heavyiron

I ran very similar cycles for years and just kept gaining but my doses were pretty high to begin with =)

Same here, I also needed to run higher doses as time went on when I first started in order to get the results I needed.




/V

I cant wait to get geared out my brain. Im thinking of cruising just to my following cycle then doing pct after that i will see hows i feel at the time.

How old r u bro? I wouldn't cruise until you are settled down and don't plan on having any/any more kids.

im 23 still a nipper can you make babies when your on gear then i was always confused to the connection between test and ur lil swimmin fishees...

Originally Posted by Digitalash

That requires coming off though right? Myostatin won't return to normal on it's own after being on for a while will it? So does myostatin come into play where natural test is concerned? I'll read the link though thank you

Edit: ok I see what you're saying, so myostatin will return to baseline after a certain amount of time on? Also I've seen this in a number of studies, lbm increases with use of testosterone even without training? I know there are other things that factor into lean body mass but a good portion of that would be muscle?

You have to think about the receptors as a gage. If you are between 10-50 (fictions numbers) your body is cool with that. The receptors recognize this as the sweet spot. When your body moves out of that range above or below for prolonged periods of time the body tries to compensate via feedback or forward loops to try to manipulate the outcome.

In the case of test, your body only wants to hold soo much muscle. Your body is lazy and muscle costs a lot of energy that could be used for better things (brain). So if your body senses that you are over the range for test it uses a forwarder loop to activate myostatin which will reduce the ability of the body to synthesis muscle. Therefore it has offset the increased testosterone. The body saves energy and is happy.

This is very simplified and dimmed down, but do you get it?

Yes this can be overcome, but it takes a large stimulus. Exogenous testosterone is known to overcome this.

Originally Posted by Digitalash

Edit: ok I see what you're saying, so myostatin will return to baseline after a certain amount of time on? Also I've seen this in a number of studies, lbm increases with use of testosterone even without training? I know there are other things that factor into lean body mass but a good portion of that would be muscle?

A lot of the studies use dexa or MRI scans and can calcualte muscle change, not just lean body mass. Muscles grow without training, but generaly in populations with muscle wasting disease (age is considered), or hypogoandism (low test). Changes will happen in healthy populations, but not to the same magnitude.

I see that makes sense, not looking for an easy way to gain muscle without work by any means lol. I'd quite literally give my left nut to keep training, but as I'm looking at potential surgery on both shoulders and will probably be out for a few months, anything I can do to maintain is very tempting lol.

besides rise in SHBG from being on aas a long time or you not adding cals as you grow,,,, NOT ITS NOT TRUE! there is not RECEPTORE degrading. this is all BS.

Originally Posted by Digitalash

here's a question, if running test for a while causes myostatin to increase/androgen receptors to downregulate, why does your natural test production continue to provide gains essentially your whole life?

Myostatin is pretty high around week 8 of a cycle but when measured later at 20 weeks, myostatin is baseline.

Androgen receptors do not down-regulate in the presence of androgen's.

Originally Posted by heavyiron

Myostatin is pretty high around week 8 of a cycle but when measured later at 20 weeks, myostatin is baseline.

Androgen receptors do not down-regulate in the presence of androgen's.

So does this mean that gains are good, stall, then pick back up? That's really what I'm starting to see now in week 14 of my current cycle (Could be the addition of the tren). Or are there other catalysts that will inhibit muscle growth.

I got stuck around 230lbs from week 7-12. Although I was stalled weight wise, I was still losing BF and having a recomp type thing going. Then around 13 I finally broke the 230 mark. This makes sense just based on myostatin, but there has to be other ways that your body will hinder muscle growth.

This makes me wonder if a minimal investment in some follistatin around week 7 would just keep the gains coming throughout the entire cycle.