Thread: Nolva vs. 19-nors! Let's end this already!

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Still waiting

Damn, no takers?

I think nolva makes progesterone receptors more sensitive and actually increases the chance of gyno with aas like Tren and deca. Correct me if I'm wrong

Originally Posted by Jt123

I think nolva makes progesterone receptors more sensitive and actually increases the chance of gyno with aas like Tren and deca. Correct me if I'm wrong

This^^^

I would not run it on-cycle with a 19-nor. Actually IMO, the only thing nolva is good for is on cycle (estrogen-related) gyno prevention. It does nothing to counteract progestin gyno and can actually make it worse.

See I disagree only because I've never had an issue. I respect GMO as much as any mod on here he is a genius with aas. I'm just saying what works for me.

This is exactly the info and input I am looking for, keep going

Here's one study that showed an increase in progesterone levels with Tamox, but a decrease with other AI's. Unfortunately, these studies are never done on men running gear. We need an "Institute of Hormonal Research for Chemical Enhancement". If someone wants to fund it...me, SloppyJ and CT will run that shit.

J Steroid Biochem Mol Biol. 2005 May;95(1-5):83-9.

Aromatase inhibitors: cellular and molecular effects.

Miller WR, Anderson TJ, White S, Larionov A, Murray J, Evans D, Krause A, Dixon JM.

Breast Unit, Western General Hospital, Edinburgh, Scotland, UK. w.r.miller@ed.ac.uk

Marked cellular and molecular changes may occur in breast cancers following treatment of postmenopausal breast cancer patients with aromatase inhibitors. Neoadjuvant protocols, in which treatment is given with the primary tumour still within the breast, are particularly illuminating. In Edinburgh, we have shown that 3 months treatment with either anastrozole, exemestane or letrozole produces pathological responses in the majority of oestrogen receptor (ER)-rich tumours (39/59) as manifested by reduced cellularity/increased fibrosis. Changes in histological grading may also take place, most notably a reduction in mitotic figures. This probably reflects an influence on proliferation as most tumours (82%) show a marked decrease in the proliferation marker, Ki67. These effects are generally more dramatic than seen with tamoxifen given in the same setting. Differences between aromatase inhibitors and tamoxifen are also apparent in changes in steroid hormone expression. Thus, immuno-staining for progesterone receptor (PgR) is reduced in almost all cases by aromatase inhibitors, becoming undetectable in many. This contrasts with effects of tamoxifen in which the most common change on PgR is to increase expression. Changes in proliferation occur rapidly following the onset of exposure to aromatase inhibitors. Thus, neoadjuvant studies with letrozole in which tumour was sampled before and after 14 days and 3 months treatment show that decreased expression of Ki67 occur at 14 days and, in many cases, the effect is greater at 14 days than 3 months. These early changes precede evidence of clinical response but do not predict for it. However, this study design has allowed RNA analysis of sequential biopsies taken during the neoadjuvant therapy. Based on clustering techniques, it has been possible to subdivide tumours into groups showing distinct patterns of molecular changes. These changes in tumour gene expression may allow definition of tumour cohorts with differing sensitivity to aromatase inhibitors and permit early recognition of response and resistance.

what works for some doesnt work for others

Originally Posted by D-Latsky

See I disagree only because I've never had an issue. I respect GMO as much as any mod on here he is a genius with aas. I'm just saying what works for me.

I appreciate that brother and what we need to remember is that everyone reacts differently. I also personally know people who took Nolva with Tren and got horrible progestin-related gyno. One of my bros subsequently got a blood panel done and his progesterone levels were seriously out of range.

I think it would present less issues with Nandrolone, as it does not have as high of an affinity for the progesterone receptor as dose Trenbolone.

Originally Posted by GMO

We need an "Institute of Hormonal Research for Chemical Enhancement". If someone wants to fund it...me, SloppyJ and CT will run that shit.

Fuck yeah, Dr. J finally gets his labcoat.

Originally Posted by GMO

I appreciate that brother and what we need to remember is that everyone reacts differently. I also personally know people who took Nolva with Tren and got horrible progestin-related gyno. One of my bros subsequently got a blood panel done and his progesterone levels were seriously out of range.

I think it would present less issues with Nandrolone, as it does not have as high of an affinity for the progesterone receptor as dose Trenbolone.

I have seen where many people take 10mg of nolva ED while on a 19-nor. They think it works. Me, I'll just stick to caber. But what it boils down to is what GMO said, whatever works for YOUR body.

I think the smart thing to do would be to not run nolva with a 19-nor and run caber or prami.

D, maybe you're just a lucky one who doesn't get prog. sides/issues. Something that I've been noticing a lot is how different debates start just based on personal experience. That is an awesome thing. But I think we need to remember that we should always recommend the safe route for anyone because either #1. They've never taken it and don't know how the react. Or #2. a Noob will come in here and read this and do it. In this case I believe the safe route would be not to take nolva and to take a prog. inhibitor. (Caber or Prami)