Thread: 100mg per week of Test to not have babies!

Check this study out. Gave Chinese brother's 500mg per month of Test UNDEC. and was 99% effective!

Testosterone Tested as Male Contraceptive

Said it doesn't work as good for white bro's. But progesterone worked better.


Testosterone Tested as Male Contraceptive

Study Shows Monthly Injections in Men Can Prevent Partners' Pregnancies
by Salynn Boyles
WebMD Health News
Reviewed by Brunilda Nazario, MD



May 6, 2009 -- After decades of delay, hormonal birth control for men may be a step closer to reality.

Monthly injections of a testosterone-based contraceptive were 99% effective for preventing partner pregnancy in what researchers say is the largest trial ever of a hormone-based male birth control approach.
Testosterone therapy is usually given to men to treat a condition resulting from a lack of testosterone. In men, testosterone controls sperm production, erections, and sex drive.

The study looked at fertile men, and treatment with testosterone was used to decrease sperm production. Testosterone treatment is known to decrease hormones of the brain that signal the testes to produce sperm.
Just over 1,000 Chinese men between the ages of 20 and 45 who had fathered at least one child within two years of enrollment took part in the study, which was published in The Journal of Clinical Endocrinology & Metabolism.

The search for a commercially viable male equivalent of the pill has been stalled in recent years, largely due to lack of interest by the pharmaceutical industry, says Elaine Lissner, who directs the Male Contraception Information Project.

"There has been a lot of consolidation within the industry, and several companies that were working on hormonal birth control for men abandoned development even though their studies were positive," she tells WebMD.
Companies lost interest, she says, because they concluded that there was not enough of a market for male birth control that required implants or frequent injections.

An oral male pill is not likely because testosterone is not as effective when taken by mouth and it can be toxic to the liver.

Studying Testosterone's Effects

The men in the Chinese study received monthly injections of a form of testosterone known as testosterone undecanoate (TU).

Lead researcher Yi-Gun Gu, MD, of Beijing's National Research Institute for Family Planning tells WebMD that while the contraceptive was found to be highly effective in the study, TU alone is not likely to be used in non-Asian populations.

Asian men seem to respond well to testosterone as a form of contraception, while studies in white men have shown it to be much less effective.

The reasons for this are not clear, but Gu tells WebMD that any hormonal birth control developed for non-Asian men is likely to include another hormone -- progestin.

Studies have shown the testosterone-progestin combination to be very effective in suppressing fertility in white men.

The Chinese men in Gu's study took monthly injections of 500 milligrams of TU in tea seed oil for 30 months. This formula is not available in the U.S. and is indicated to treat low testosterone levels with injections typically given every three months.

Over the course of the trial, nine pregnancies occurred in the partners of 1,045 study participants, or roughly one pregnancy for every 100 men.

There was no evidence of major side effects, and all but two of the men in the study returned to normal fertility after stopping the injections. The average time it took for the men to return to normal fertility was around six and a half months.

Gu says more study is needed to examine the long-term safety of the TU treatment.

In an editorial accompanying the study, male fertility researcher David Handelsman, MD, of the University of Sydney writes that several other promising male contraceptives are under development with little help from the pharmaceutical industry.

He argues that there is a clear need and demand for a practical hormonal contraceptive option for men.

"Whatever the reasons for the strike by large pharmaceutical companies ... the disconnect between the lay and medical perception of both a need and a niche for [hormonal male contraception], on the one hand, and the failure of the pharmaceutical market to deliver a product, despite the demonstration of feasibility, is puzzling, indeed," he writes.

Lissner says governments and nonprofit foundations are taking the lead in developing new hormonal and nonhormonal male birth control.

She points out that the Gates Foundation has made contraceptive development one of the four pillars of its new reproductive strategy.
"We are very fortunate to have a more promising political environment than we have had," she says. "This is a good time for male contraception, but I don't think we can count on the pharmaceutical companies to do this."

Iv always have been on big cycles when my wife always got pregnant