Question for a Geezer

**SFW** · 11-05-2011, 08:07 AM

Would high levels of DHEA (500 mg ed) and 6-oxo (500 mg ed) help raise the T level of a 70 year old man? Would it be noticable? More for mood etc, not ergogenic. And lastly, would it be safe?

**bigmoe65** · 11-05-2011, 03:34 PM

Im curious how this works for you.

**Cerberus777** · 11-06-2011, 04:42 AM

I did exacly that, 8 years ago... Bad blood presure and water retention, dhea converts to estrogen in diffrent ways an AI might not help

**GMO** · 11-06-2011, 07:03 AM

Originally Posted by SFW

Would high levels of DHEA (500 mg ed) and 6-oxo (500 mg ed) help raise the T level of a 70 year old man? Would it be noticable? More for mood etc, not ergogenic. And lastly, would it be safe?

There is evidence that OXO will boost test by driving E2 low, but no studies have proven that it will aid in muscle growth or performance. I also doubt it would have much effect in an elderly sub.

As far as DHEA is concerned, it does nothing for test levels. There is little solid evidence from proven studies that DHEA boosts natural test levels. About the only thing it is good for IMO is keeping cortisol levels at bay during PCT, and Vit C actually does a better job at this.

The best thing to raise the test levels of a 70 year old without TRT injects is Androgel.

**SFW** · 11-06-2011, 07:11 AM

no studies have proven that it will aid in muscle growth or performance

Its not for ergo purposes though. He's 72, good health aside from diabetes typeII.

Looks like androl gel could be a choice for him.

So who is a candidate for DHEA use? I always thought that the elderly would see benefits.

**SloppyJ** · 11-06-2011, 07:13 AM

Originally Posted by SFW

72, good health aside from diabetes typeII..

Risky.

**GMO** · 11-06-2011, 07:14 AM

Here, I dug up this study that did show an increase in test and estrogen after transdermal application of DHEA (the bio-availability is much higher transdermal than oral). It also decreased LH production:

Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men.

Sulcová J, Hill M, Hampl R, Masek Z, Novácek A, Ceska R, Stárka L.
Source

Institute of Endocrinology, AREKO, Ltd., First Faculty of Medicine, Charles University, Prague, Czech Republic. jsulcova@endo.cz

Abstract

In order to ascertain the kinetics of absorption and metabolism of transdermally administered dehydroepiandrosterone (DHEA), 10 men 29-72 years old (mean 52.4+/-14.5) received 50 mg DHEA/day in a gel applied onto the skin of the abdomen for 5 consecutive days. The objective was to establish the extent to which DHEA influences the levels of gonadotropins, sex hormone-binding globulin and lipids. It was found that DHEA is well absorbed and rapidly metabolized to its sulfate (DHEAS), androstenedione, and consequently to testosterone and estradiol. The DHEA levels that markedly increased after the first doses gradually declined already during the application, and this decline proceeded even after it was discontinued, reaching levels significantly lower than the original ones. On the other hand, the levels of DHEA metabolites (with the exception of DHEAS) rose during the application and reached values significantly higher than the basal ones within 5 weeks. This effect was accompanied by significantly decreased levels of LH. The serum levels of lipids, namely of cholesterol (both HDL and LDL cholesterol), triglycerides, apolipoproteins A-I and B and lipoprotein(a) after DHEA application were not changed significantly, and the atherogenic index (AI) remained unaltered. However, some correlations between hormones and lipids were found. Negative correlations concerned the following indices: DHEA/Lp(a); DHEAS/cholesterol; DHEA, DHEAS, testosterone/TG; testosterone/AI. On the other hand, LH, FSH/cholesterol, FSH, SHBG/LDL cholesterol, FSH/Apo B, Lp(a) correlated positively. It can be concluded that transdermal short-time application of DHEA results in a decrease of endogenous DHEA after finishing the treatment, with a parallel marked increase in the levels of sex hormones. Using this application protocol, exogenous DHEA neither altered the lipid spectrum, nor did it influence the atherogenic index.

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