Thread: t3 + DNP

Approximately 0.1% of the population suffered from cataracts, which has been put down to a Vitamin C deficiency by – genetic predisposition. According to a study in the 1950s by Ogino and Yasukura, they found that DNP users with a genetic predisposition to cataracts had a higher chance of developing it, but with vitamin C supplementation, or a vitamin C rich diet, cataracts didn’t develop.

The best research came in the 1950's by Ogino and Yasukura. They found that guinea pigs fed a vitamin C deficient diet while on DNP developed cataracts, while those that supplemented with vitamin C did not. As they explained, "In these experiments, it is clear that there is a close relationship between the production of cataract and vitamin-C deficiency." They then went on, though a series of fascinating steps, to isolate the cataractogenic metabolite of DNP (the chemical derived from DNP that can cause cataracts). They identified it as 2-amino-p-quinonimine. They found that the hydroxyl- and nitro-radicals of DNP in the p-position of the benzene ring are essential to the production of dinitrophenol cataract. There are various other cataractogenic agents that are similar quinoid substances.

Ogino and Yasukura said "This suggests that a genetic predisposition plays an important role in susceptibility to this cataract. This notion is strengthened by the fact that, in spite of extensive experiments of long duration by many authors, it has been found impossible to produce dinitrophenol cataract experimentally in various other species, namely, in rats, rabbits, guinea pigs, and dogs, although Bettman observed dinitrophenol cataract in a special strain of mice." If there's a genetic predisposition, then some people might be much more likely to develop cataracts than others. It's also possible that while a few people are susceptible, others are essentially immune.

Originally Posted by vindicated346

Approximately 0.1% of the population suffered from cataracts, which has been put down to a Vitamin C deficiency by – genetic predisposition. According to a study in the 1950s by Ogino and Yasukura, they found that DNP users with a genetic predisposition to cataracts had a higher chance of developing it, but with vitamin C supplementation, or a vitamin C rich diet, cataracts didn’t develop.

The best research came in the 1950's by Ogino and Yasukura. They found that guinea pigs fed a vitamin C deficient diet while on DNP developed cataracts, while those that supplemented with vitamin C did not. As they explained, "In these experiments, it is clear that there is a close relationship between the production of cataract and vitamin-C deficiency." They then went on, though a series of fascinating steps, to isolate the cataractogenic metabolite of DNP (the chemical derived from DNP that can cause cataracts). They identified it as 2-amino-p-quinonimine. They found that the hydroxyl- and nitro-radicals of DNP in the p-position of the benzene ring are essential to the production of dinitrophenol cataract. There are various other cataractogenic agents that are similar quinoid substances.

Ogino and Yasukura said "This suggests that a genetic predisposition plays an important role in susceptibility to this cataract. This notion is strengthened by the fact that, in spite of extensive experiments of long duration by many authors, it has been found impossible to produce dinitrophenol cataract experimentally in various other species, namely, in rats, rabbits, guinea pigs, and dogs, although Bettman observed dinitrophenol cataract in a special strain of mice." If there's a genetic predisposition, then some people might be much more likely to develop cataracts than others. It's also possible that while a few people are susceptible, others are essentially immune.

Great post!


5"10
200lbs
BF = around 15% (guess)
600mg Tren E, 325mg Test Cyp week

Originally Posted by vindicated346

I posted this earlier in the thread, but this is Conciliator's thoughts on T3 shutdown

Conciliator post on t3 and DNP:

"DNP doesn't shut down the thyroid. This is a common myth. AAS and DNP have a similar effect on thyroid, through a similar mechanism of action. While androgens reduce the concentration of thyroid binding globulin (TBG), DNP occupies thyroid binding proteins, which has the same result... less protein to bind to thyroid. This may initially result in higher serum levels and accelerated clearance, but after a short term alteration in thyroid function a new steady state is soon reached in which thyroid function is normal, despite potentially reduced serum levels of total T4 and total T3. As one paper on DNP explained, "this action could lower the total hormone concentration in serum but should have no persistent effect on thyroid function". This means that even though the level of thyroid hormones in the blood can potentially be lower than normal, thyroid function will still be normal. What I've seen happen most of the time, however, is that thyroid levels hardly change.

There's a case study that's often posted as evidence for thyroid dysfunction from DNP, but I'm of the opinion that the bodybuilders in question had low thyroid levels not because of the DNP, but because they were taking T3 during their cycle. Exogenous T3 definitely will suppress endogenous production. I had a Norwegian translate the paper and it was unclear why they had low thyroid levels. They didn't test for reverse thyroid when they could have, which would have made the cause clearer.

I also have a friend who's a doctor of internal medicine who ran 600mg/day of crystal DNP for 3-4 months (went from 320 lbs down to the mid 200's). He gave himself frequent blood tests and said his thyroid didn't budge. I've heard feedback from several others who did blood work showing the same thing.

I'm just not convinced that DNP results in any thyroid dysfunction. You definitely do NOT need to take thyroid along with DNP. Considering how notoriously catabolic thyroid is, I'd recommend leaving it out of your dieting plan."

told ya so

yo vin.....that response was lifted from anabolex no? if i remember im all over that thread

its been posted several times through out many a board. I follow the tried and true words of conciliator,along with my own research, but The man has been dead on.

yeah he knows his shit....the only thing i wouldnt do is clen on dnp....with the dnp dehydration that you just cant escape and clen i get CRAMPS very bad.....worse than clen alone........i would wait to run clen after getting off because clen kills my appetite and i wouldnt want carb cravings to come back to square one after suffering thu sweat and breathing like darth vader..........besides with the t-3 BOOST you will get after cycle + clen you wouldnt even need to add t-3..........i still would add glycerol and TAURINE though because most cramps suck the taurine right out of your muscles.......ouch.....................

in a few weeks a new addition to my line is coming out with some known fat burners and appetite suppresants with only 50mg DNP (meant to only take twice a day then down to once a day) to help solidify fat loss from heavy cycles by offering COMFORTABLE uncoupling as well as curb carb cravings.....so youll still burn fat as the "flatness" dissapears...........i may even reduce it to 40mg not sure yet.....depends on subjects experience i guess..........anyways im not ready to divulge the exact date of release of formula just yet until i accquire all i need.................it would be designed to take 2-4 weeks post "heavy cycle" and will also offer thyroid support but the more i toss it around in my head the more im sure i wont need that......i would be better off with chems to KEEP THE FUCKIN FORKS OUT OF YOUR MOUTHS..........conciliator had agreed with me 100% in the past regarding this.......we just disagree on the clen subject...............................thoughts?

Originally Posted by the_anapolack

yeah he knows his shit....the only thing i wouldnt do is clen on dnp....with the dnp dehydration that you just cant escape and clen i get CRAMPS very bad.....worse than clen alone........i would wait to run clen after getting off because clen kills my appetite and i wouldnt want carb cravings to come back to square one after suffering thu sweat and breathing like darth vader..........besides with the t-3 BOOST you will get after cycle + clen you wouldnt even need to add t-3..........i still would add glycerol and TAURINE though because most cramps suck the taurine right out of your muscles.......ouch.....................

in a few weeks a new addition to my line is coming out with some known fat burners and appetite suppresants with only 50mg DNP (meant to only take twice a day then down to once a day) to help solidify fat loss from heavy cycles by offering COMFORTABLE uncoupling as well as curb carb cravings.....so youll still burn fat as the "flatness" dissapears...........i may even reduce it to 40mg not sure yet.....depends on subjects experience i guess..........anyways im not ready to divulge the exact date of release of formula just yet until i accquire all i need.................it would be designed to take 2-4 weeks post "heavy cycle" and will also offer thyroid support but the more i toss it around in my head the more im sure i wont need that......i would be better off with chems to KEEP THE FUCKIN FORKS OUT OF YOUR MOUTHS..........conciliator had agreed with me 100% in the past regarding this.......we just disagree on the clen subject...............................thoughts?

If Clen makes you feel like shit, then don't take it. With DNP you can and actually are slightly encouraged to use stimulants, DNP is not a stimulant so to counter lethargic feeling from DNP I personally would drink lots of coffee or a few caffeine pills to keep me going.

When I run DNP I don't change my diet at all, 209mg-400mg a day of DNP. Since it increases your metabolic rate 50%, you are essentially cutting your daily calorie intake in half or you can think of it as increasing calories burned by 50%.

Same stable diet plus DNP equals fat loss. This is a nice trick to cut up without starving yourself on a cutting diet.


5"10
200lbs
BF = around 15% (guess)
600mg Tren E, 325mg Test Cyp week

i do use stims with dnp.....i prefer ephedrine/caffine/yohimbe........................also subultiamine and some of "animal's" products which he wont disclose ingredients to give me some vavavoom............i just dont tolerate clen very well and with the additional cramping i advise against it....EVERYONE cramps on clen.......but cramping while dehydrated is just plain unecessary

anapolack, the only real suggestion I could make would be to substitute clen for albuterol, No wear near the sides, but still can reap some of the benefits of fat burning. I just stick with DNP alone and stay around 400mg, but carrying my own line, I can run a bit longer than most. Been running Test P/Tren while running my DNP at 400mg for the past 5 weeks, weight has dropped from about 260 to 240, but im stronger than when i started

Originally Posted by vindicated346

anapolack, the only real suggestion I could make would be to substitute clen for albuterol, No wear near the sides, but still can reap some of the benefits of fat burning. I just stick with DNP alone and stay around 400mg, but carrying my own line, I can run a bit longer than most. Been running Test P/Tren while running my DNP at 400mg for the past 5 weeks, weight has dropped from about 260 to 240, but im stronger than when i started

Is it really needed? DNP will burn pure fat and is insanely stronger than Clen...


5"10
200lbs
BF = around 15% (guess)
600mg Tren E, 325mg Test Cyp week

i used albuterol....like i said i prefer other stims....even ephedrine to clen while on dnp...............and yeah its like adding a firecracker to dynamite but what the goal is fighting fatigue and appetite

I've gotten away from just about anything that messes with my CNS directly. I do dose Caffeine from time to time while on DNP, but thats about it, I use fruit as my way to combat lethargy on DNP, and it works just fine for me

Originally Posted by vindicated346

I've gotten away from just about anything that messes with my CNS directly. I do dose Caffeine from time to time while on DNP, but thats about it, I use fruit as my way to combat lethargy on DNP, and it works just fine for me

Agreed. I can only tolerate being lethargic for a few days.


5"10
200lbs
BF = around 15% (guess)
600mg Tren E, 325mg Test Cyp week

Originally Posted by Thresh

DNP is not a stimulant so to counter lethargic feeling from DNP I personally would drink lots of coffee or a few caffeine pills to keep me going.

PreWO: 200mg DNP, 25mcg T3, ECA stack and 30mg of Halotestin.

Originally Posted by GMO

PreWO: 200mg DNP, 25mcg T3, ECA stack and 30mg of Halotestin.

Jesus


5"10
200lbs
BF = around 15% (guess)
600mg Tren E, 325mg Test Cyp week

drink lots of water/glycerol on that brah

What will dnp do for this? get shred nasty?

hell yeah....with that slim waist youll look like a buff healthy crackhead ........what i would do to have a waist like that

Originally Posted by bigbenj

What will dnp do for this? get shred nasty?

It will help. 200mg a day for 14-21 days and you'll be happy. Keep the diet in check and do some cardio. 10 days after your last dose when the water weight falls off, you should be 10-15lbs lighter. Drop your carbs out for 3-5 days and you'll drop down another 4-9lbs.

buff healthy crackhead???


I like that shit!!!! hahaha

Originally Posted by XYZ

It will help. 200mg a day for 14-21 days and you'll be happy. Keep the diet in check and do some cardio. 10 days after your last dose when the water weight falls off, you should be 10-15lbs lighter. Drop your carbs out for 3-5 days and you'll drop down another 4-9lbs.

Nice! I appreciate the advice.

Originally Posted by bigbenj

buff healthy crackhead???


I like that shit!!!! hahaha

Originally Posted by bigbenj

Nice! I appreciate the advice.

soooo, you gonna take the plunge?

Bigbenji, you to me would be a perfect candidate to run DNP, pretty lean and it would only help with maintaining the size you do have while still shredding up

Originally Posted by Bottom's Up

soooo, you gonna take the plunge?

I'm about 99.9999999% percent sure. Fuck it, its a go haha.

Originally Posted by vindicated346

Bigbenji, you to me would be a perfect candidate to run DNP, pretty lean and it would only help with maintaining the size you do have while still shredding up

I also just started my test and tren also, I think I already told you that before though, so I think the results could potentially be amazing.

http://www.atsdr.cdc.gov/toxprofiles/tp64-c2.pdf

Damn, dog, I have ADD, I need some cliff notes lol.
I'd like to see the exposure levels that lead to some of these side effects. I'll keep reading it, if I can pay attention long enough.

Edit: I see mice died from 1250-2500mg of dnp/day. No surprise there, as its upwards of 6x what people are recommending in this thread, and mice only weight a couple of pounds at most.

I'm going to find out for myself through real life experience. This is just going to turn into an online study posting session. One person will post a study pro-dnp, then someone will post a study that is anti.

Originally Posted by bigbenj

Damn, dog, I have ADD, I need some cliff notes lol.
I'd like to see the exposure levels that lead to some of these side effects. I'll keep reading it, if I can pay attention long enough.

Edit: I see mice died from 1250-2500mg of dnp/day. No surprise there, as its upwards of 6x what people are recommending in this thread, and mice only weight a couple of pounds at most.

not to menton thats alot for little tiny MICE.......and the first known people with heavy dnp exposure were miners who many led long lives if they didnt die of an accident...........why is there no mention in that about the anti-cancer properties? the big anti-oxidant values and the dna/rna protection not to mention the stimulation for increasing mitochondria?