Caffeine increase the anabolic effect of oxandrolone
According to the study caffeine is reported to accelerate absorption of some drugs. Our data show that caffeine alters the excretion profile of oxandrolone. With 300 mg of caffeine, there were very large increases (about 20 times) in the amount and rate of excretion for both oxandrolone and epioxandrolone
The Portuguese, who are linked to the doping Laborat?rio the analises the Dopagem , had heard from police that some Portuguese steroids users swore by a combination of caffeine and oxandrolone. The researchers wondered what the point of that combination could be, and dived into the library.
There they came across studies that say that can improve. Caffeine absorption and action of paracetamol [J Clin Pharmacol. 2007 Jun; 47 (6) :715-26]. Would that caffeine also with oxandrolone?
The researchers answered that question with an experiment in which they gave a subject with normal caffeine consumption of three cups of espresso a day a tiny amount of 0.4 mg oxandrolone.
The researchers then looked at how much caffeine for 40 hours, oxandrolone oxandrolone and the inactive metabolite epioxandrolone [structural formula shown here] there appeared in the urine of the subject. The figure below shows only what happened during the first 14 hours. Click on it for the full figure.
Next, the researchers repeated the experiment, but gave the subject there when 300 mg of caffeine in pill form at. You can see in the figure [click for full figure] that the amount of oxandrolone and epioxandrolone fold, respectively 20 and 15 increased by caffeine above.
The researchers suspect that their experiment shows that caffeine intake of oxandrolone greatly improves the body. " Practically this Means That similar Concentrations / Effects May Be Achieved using lower dosages , "they write. " Other anabolic steroids shouldering usefull be Investigated . "
Source: Laborat?rio the analises the Dopagem, IDP, Lisboa, Portugal. B. Salema, J. Ruivo, X. de la Torre, M. Sekera, L. Horta. Oxandrolone excretion: effect of caffeine dosing. Published www.adop.pt.