Various 1-T Cyp conversions to other AAS

prolangtum · 12-24-2003, 12:08 PM

Courtesy of Spidey:

This thread is strictly for entertainment purposes. I do not use or condone the use of illegal drugs. I have not performed these syntheses, nor will I consider doing so.

BOLDENONE CYPIONATE (fast acting EQ)

Step 1: 1-Test cyp is brominated in the 4 position with 2,4,4,6-tetrabromocyclohexa-2,5-dione in ether with catalytic HCl. The product is 4-bromo-1-testosterone cypionate. There are other methods to achieve this bromination as well but this one should work very cleanly with a minimum of side reactions.

Step 2: the bromide is eliminated to give the 4,5-double bond by stirring the above product in DBU for 10 to 20 minutes. The overall yield of bold cyp should be around 75 to 80%

METHANDROSTENOLONE (dbol)

Step 1: The bold cyp from above is stirred in boiling benzene with ethylene glycol and catalytic acid. A Dean-Stark trap should be used to remove water as it is formed. This protects the 3-one as an ethylene ketal.

Step 2: The above protected bold cyp is stirred in boiling methanol/water with NaOH to remove the cyp ester.

Step 3: The 17-OH is oxidized to a ketone with any of a variety of chromium VI reagents.

Step 4: The above 17-one is reacted with methyl magnesium iodide. The reaction is quenched with water and acid. Heating the mixture with the water and acid will remove the ethylene ketal as well, leaving you with methandrostenolone.

METHENOLONE CYPIONATE (Primobolin, although real primo is the enanthate, not the cypionate, I expect little difference in function.

Step 1: 1-Test cyp is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with liquid bromine. The product is 2-bromo-1-methyl-DHT.

Step 2: The bromine is eliminated to give back the 1,2-double bond by stirring with DBU as in the synthesis of bold cyp. The product is methenolone cypionate.

MESTEROLONE (proviron)

1-Test base is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with water to afford mesterolone in a single step.

OXANDROLONE (Anavar)

Step 1: Starting with 1-test base, the 3-one is protected as the ethylene ketal as in the above synthesis of methandrostenolone.

Step 2: The 17-OH is oxidized to a 17-one with chomium VI reagent.

step 3: The 17-methyl is attached with methyl magnesium iodide and the crude reaction mixture is treated with water and acid to quench the reaction and remove the ketal protecting group. The product is 17-methyl-1-test.

Step 4: the 17-methy-1-test is treated with ozone in methanol and then NaOH is added. This allows the purification of the intermediate by recrystallization of the sodium salt. The result is that the double bond is cleaved to give a carboxyolic acid (salt) on one side and an aldehyde on the other. The salt is dissolved in water and acidified to pH=4. NaBH4 is added to reduce the intermediate aldehyde. The resulting alcohol will spontaniously close with the carboxylic acid to give the desired lactone ring. The product is oxandrolone.

OXYMETHYLONE (Anadrol)

17-methyl-1-test from above is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with N-formylmorpholine to give oxymethylone as the product.

DROMOSTANOLONE propionate (Masterone)

Step 1: 1-test base is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with methyl iodide to install the 2-methyl group.

Step 2: the dromostanolone resulting from step 1 is esterified with propanoyl chloride and pyridine to afford the product, masterone.

prolangtum · 12-24-2003, 12:09 PM

From M 1T

Anavar, for instance is 6 steps from 1-test but 4 of those steps are making M-1-T (the 3-one must be protected; the 17-OH oxidized to a 17-one; the 17-one methylated with meLi of grignard; and finally, the 3-one deprotected).

Var is only 2 steps away from M-1-T. That can be done in an afternoon on multigram scale. This means much less time in the lab risking getting caught. It is well worth the $15 a gram (unless you can tell me where to buy var powder for $15 a gram, LOL).

I will still make my methenolone and mesterolone from simple 1-test. The nandrolone is coming from 19-norandrost-4-ene-3,17-diol (19-nor-diol). 1Fast400 sells the 1-test for $4 a gram in bulk and the 19-nor-diol powder for $2.50 a gram.

Power Rabbit · 12-24-2003, 06:20 PM

very interesting stuff...I really really wish prince would add a chem sub board....im definately gonna have to give a few of these a try

**Mudge** · 12-24-2003, 06:29 PM

If the activity was here then it probably could be done, otherwise it just becomes board hell. If people aren't posting all kinds of chemical stuff, then there is no need for it.

Billy_Bathgate is one of the chemists on the boards, I would be curious if he has done any of these.

crackerjack414 · 12-24-2003, 06:45 PM

doesnt billy also go by the hamburgler or something like that smart guy if we are talking about the same person

**Mudge** · 12-24-2003, 06:47 PM

The Hamburgler Mod, he is on Anabolic Review and B4L the most I think.

Power Rabbit · 12-24-2003, 08:02 PM

christ there are too many boards

**Mudge** · 12-25-2003, 01:55 AM

Something over 70 last time I saw count, I think Basskiller had a post on AP long long ago with a list of boards.

12-24-2003, 12:08 PM	#1
prolangtum Registered User Join Date: Dec 2003 Posts: 353	Various 1-T Cyp conversions to other AAS Courtesy of Spidey: This thread is strictly for entertainment purposes. I do not use or condone the use of illegal drugs. I have not performed these syntheses, nor will I consider doing so. BOLDENONE CYPIONATE (fast acting EQ) Step 1: 1-Test cyp is brominated in the 4 position with 2,4,4,6-tetrabromocyclohexa-2,5-dione in ether with catalytic HCl. The product is 4-bromo-1-testosterone cypionate. There are other methods to achieve this bromination as well but this one should work very cleanly with a minimum of side reactions. Step 2: the bromide is eliminated to give the 4,5-double bond by stirring the above product in DBU for 10 to 20 minutes. The overall yield of bold cyp should be around 75 to 80% METHANDROSTENOLONE (dbol) Step 1: The bold cyp from above is stirred in boiling benzene with ethylene glycol and catalytic acid. A Dean-Stark trap should be used to remove water as it is formed. This protects the 3-one as an ethylene ketal. Step 2: The above protected bold cyp is stirred in boiling methanol/water with NaOH to remove the cyp ester. Step 3: The 17-OH is oxidized to a ketone with any of a variety of chromium VI reagents. Step 4: The above 17-one is reacted with methyl magnesium iodide. The reaction is quenched with water and acid. Heating the mixture with the water and acid will remove the ethylene ketal as well, leaving you with methandrostenolone. METHENOLONE CYPIONATE (Primobolin, although real primo is the enanthate, not the cypionate, I expect little difference in function. Step 1: 1-Test cyp is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with liquid bromine. The product is 2-bromo-1-methyl-DHT. Step 2: The bromine is eliminated to give back the 1,2-double bond by stirring with DBU as in the synthesis of bold cyp. The product is methenolone cypionate. MESTEROLONE (proviron) 1-Test base is reacted with tetramethyl dilithium pentacuprate (formed in-situ from CuI and meLi). The reaction is quenched with water to afford mesterolone in a single step. OXANDROLONE (Anavar) Step 1: Starting with 1-test base, the 3-one is protected as the ethylene ketal as in the above synthesis of methandrostenolone. Step 2: The 17-OH is oxidized to a 17-one with chomium VI reagent. step 3: The 17-methyl is attached with methyl magnesium iodide and the crude reaction mixture is treated with water and acid to quench the reaction and remove the ketal protecting group. The product is 17-methyl-1-test. Step 4: the 17-methy-1-test is treated with ozone in methanol and then NaOH is added. This allows the purification of the intermediate by recrystallization of the sodium salt. The result is that the double bond is cleaved to give a carboxyolic acid (salt) on one side and an aldehyde on the other. The salt is dissolved in water and acidified to pH=4. NaBH4 is added to reduce the intermediate aldehyde. The resulting alcohol will spontaniously close with the carboxylic acid to give the desired lactone ring. The product is oxandrolone. OXYMETHYLONE (Anadrol) 17-methyl-1-test from above is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with N-formylmorpholine to give oxymethylone as the product. DROMOSTANOLONE propionate (Masterone) Step 1: 1-test base is reduced with lithium in liquid ammonia. The ammonia is carefully evaporated under a dry N2 atmosphere to give a dry, crystalline enolate. The enolate is dissolved in dry THF and treated with methyl iodide to install the 2-methyl group. Step 2: the dromostanolone resulting from step 1 is esterified with propanoyl chloride and pyridine to afford the product, masterone.
	Mod @ Bulknutrition Forums Mod @ superiormuscle.com Mod @ steroidsupport.com Designersupps.com Bulknutrition.com Blackstarlabs.com

12-24-2003, 12:09 PM	#2
prolangtum Registered User Join Date: Dec 2003 Posts: 353	From M 1T Anavar, for instance is 6 steps from 1-test but 4 of those steps are making M-1-T (the 3-one must be protected; the 17-OH oxidized to a 17-one; the 17-one methylated with meLi of grignard; and finally, the 3-one deprotected). Var is only 2 steps away from M-1-T. That can be done in an afternoon on multigram scale. This means much less time in the lab risking getting caught. It is well worth the $15 a gram (unless you can tell me where to buy var powder for $15 a gram, LOL). I will still make my methenolone and mesterolone from simple 1-test. The nandrolone is coming from 19-norandrost-4-ene-3,17-diol (19-nor-diol). 1Fast400 sells the 1-test for $4 a gram in bulk and the 19-nor-diol powder for $2.50 a gram.
	Mod @ Bulknutrition Forums Mod @ superiormuscle.com Mod @ steroidsupport.com Designersupps.com Bulknutrition.com Blackstarlabs.com

12-24-2003, 06:29 PM	#4
Mudge Dieting I swear! Super Moderator Join Date: Jun 2002 Location: Here Posts: 23,149 Photos: 1	If the activity was here then it probably could be done, otherwise it just becomes board hell. If people aren't posting all kinds of chemical stuff, then there is no need for it. Billy_Bathgate is one of the chemists on the boards, I would be curious if he has done any of these.
	Kinesiology Vote @ Top 25 Deads Comp Bench Motivation Bench form MaxCalc Charles Poliquin When I let go of what I am, I become what I might be. Lao-Tzu I don't know any sources so don't ask - thanks

12-25-2003, 01:55 AM	#8
Mudge Dieting I swear! Super Moderator Join Date: Jun 2002 Location: Here Posts: 23,149 Photos: 1	Something over 70 last time I saw count, I think Basskiller had a post on AP long long ago with a list of boards.
	Kinesiology Vote @ Top 25 Deads Comp Bench Motivation Bench form MaxCalc Charles Poliquin When I let go of what I am, I become what I might be. Lao-Tzu I don't know any sources so don't ask - thanks

Thread Tools
Show Printable Version Email this Page
Display Modes
Linear Mode Switch to Hybrid Mode Switch to Threaded Mode

12-24-2003, 06:20 PM	#3
Power Rabbit The Bunny Is Bulking! Elite Member Join Date: Nov 2003 Location: Virginia Posts: 1,027 Photos: 3	very interesting stuff...I really really wish prince would add a chem sub board....im definately gonna have to give a few of these a try

12-24-2003, 06:45 PM	#5
crackerjack414 Registered User Join Date: Jun 2002 Location: cali Posts: 644	doesnt billy also go by the hamburgler or something like that smart guy if we are talking about the same person

12-24-2003, 06:47 PM	#6
Mudge Dieting I swear! Super Moderator Join Date: Jun 2002 Location: Here Posts: 23,149 Photos: 1	The Hamburgler Mod, he is on Anabolic Review and B4L the most I think.

12-24-2003, 08:02 PM	#7
Power Rabbit The Bunny Is Bulking! Elite Member Join Date: Nov 2003 Location: Virginia Posts: 1,027 Photos: 3	christ there are too many boards