Thread: Site specific estrogen blockers

Is it true that the ER (estrogen receptor) is somehow different in different tissues? I was reading that tamoxifen (Nolvadex) was very effective at binding to the ER in breast tissue, but not effective at blocking estrogen in the hypothalmus or pituitary and therefore does not restore LH. The article then said Clomid kind of picks up there and increases LH production, it didn't say HOW, but I would assume clomid increases LH by blockin estrogen therefore signaling a drop ion sex hormones which signals a production of LH.
If that's how clomid works, why wouldn't nolvadex do the same thimg?
Do I need to add clomid to my PCT?

I'm using both clomid and nolva right now on my PCT. I feel pretty good, definetly 10x better than with using clomid only for PCT