Thyroid rebound

**Mudge** · 09-17-2005, 10:31 PM

People keep asking about this one.

N Engl J Med 1975 Oct 2;293(14):681-4

Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy.

Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH.

The pattern of thyrotropin secretion was analyzed in seven euthyroid women, before and after withdrawal of long-term thyroid hormone, by serial measurements of thyroid 131l uptake, serum thyroxine, tri-iodothyronine, and thyrotropin concentrations, and the response to thyrotropin-releasing hormone. During exogenous hormone administration, 131l uptake was suppressed, and serum thyrotropin concentrations before and after administration of thyrotropin-releasing hormone were undetectable.

After withdrawal of exogenous hormone, thyrotropin secretory function was transiently impaired, as indicated by undetectable basal thyrotropin concentrations together with absence of response to thyrotropin-releasing hormone, and subsequently by normal values of basal thyrotropin concentration and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine concentrations were subnormal.

Decreased thyrotropin reserve persisted for two to five weeks. Detectable values of serum thyrotropin (less than 1.2 muU per milliliter) and a normal 131l uptake usually occurred concurrently in two to three weeks. Serum thyroxine concentration returned to normal at least four weeks after hormone withdrawal.

Tha Don · 09-18-2005, 04:47 AM

can't this be avoided by tapering off?

**Mudge** · 09-18-2005, 02:05 PM

Even a small amount causes suppression, but my whole point was whats the big deal with a couple weeks when you've been on for YEARS? People seem to think that hardcore shutdown is going to be a problem, I never had any rebound at all although I wasn't on for years, only 6 weeks.

AusBB · 09-23-2005, 05:49 PM

I heard that it has a bigger shutdown effect on woman. Not sure how true that is.

09-17-2005, 10:31 PM	#1
Mudge Dieting I swear! Super Moderator Join Date: Jun 2002 Location: Here Posts: 23,149 Photos: 1	Thyroid rebound People keep asking about this one. N Engl J Med 1975 Oct 2;293(14):681-4 Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy. Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH. The pattern of thyrotropin secretion was analyzed in seven euthyroid women, before and after withdrawal of long-term thyroid hormone, by serial measurements of thyroid 131l uptake, serum thyroxine, tri-iodothyronine, and thyrotropin concentrations, and the response to thyrotropin-releasing hormone. During exogenous hormone administration, 131l uptake was suppressed, and serum thyrotropin concentrations before and after administration of thyrotropin-releasing hormone were undetectable. After withdrawal of exogenous hormone, thyrotropin secretory function was transiently impaired, as indicated by undetectable basal thyrotropin concentrations together with absence of response to thyrotropin-releasing hormone, and subsequently by normal values of basal thyrotropin concentration and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine concentrations were subnormal. Decreased thyrotropin reserve persisted for two to five weeks. Detectable values of serum thyrotropin (less than 1.2 muU per milliliter) and a normal 131l uptake usually occurred concurrently in two to three weeks. Serum thyroxine concentration returned to normal at least four weeks after hormone withdrawal.
	Kinesiology Vote @ Top 25 Deads Comp Bench Motivation Bench form MaxCalc Charles Poliquin When I let go of what I am, I become what I might be. Lao-Tzu I don't know any sources so don't ask - thanks

09-18-2005, 02:05 PM	#3
Mudge Dieting I swear! Super Moderator Join Date: Jun 2002 Location: Here Posts: 23,149 Photos: 1	Even a small amount causes suppression, but my whole point was whats the big deal with a couple weeks when you've been on for YEARS? People seem to think that hardcore shutdown is going to be a problem, I never had any rebound at all although I wasn't on for years, only 6 weeks.
	Kinesiology Vote @ Top 25 Deads Comp Bench Motivation Bench form MaxCalc Charles Poliquin When I let go of what I am, I become what I might be. Lao-Tzu I don't know any sources so don't ask - thanks

09-23-2005, 05:49 PM	#4
AusBB Aus BB Join Date: Sep 2005 Location: Australia Posts: 5	I heard that it has a bigger shutdown effect on woman. Not sure how true that is.
	Aus BB Aus Bodybuilding Forum, Home of Australian Bodybuilding

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09-18-2005, 04:47 AM	#2
Tha Don Registered User Join Date: Aug 2003 Location: Nottingham, England Posts: 3,826 Photos: 33	can't this be avoided by tapering off?