TJ Cline

Testosterone production declines naturally with age. Testosterone deficiency (TD) may result from disease or damage to the hypothalamus, pituitary gland, or testicles that inhibits hormone secretion and testosterone production, and is also known as hypogonadism. Depending on age, insufficient testosterone production can lead to abnormalities in muscle and bone development, underdeveloped genitalia, and diminished virility.

Testosterone is the androgenic hormone primarily responsible for normal growth and development of male sex and reproductive organs, including the penis, testicles, scrotum, prostate, and seminal vesicles. It facilitates the development of secondary male sex characteristics such as musculature, bone mass, fat distribution, hair patterns, laryngeal enlargement, and vocal chord thickening. Additionally, normal testosterone levels maintain energy level, healthy mood, fertility, and sexual desire.

The testes produce testosterone regulated by a complex chain of signals that begins in the brain. This chain is called the hypothalamic-pituitary-gonadal axis. The hypothalamus secretes gonadotropin-releasing hormone (GnRH) to the pituitary gland in carefully timed pulses (bursts), which triggers the secretion of leutenizing hormone (LH) from the pituitary gland. Leutenizing hormone stimulates the Leydig cells of the testes to produce testosterone. Normally, the testes produce 4–7 milligrams (mg) of testosterone daily.

Incidence and Prevalence
Testosterone production increases rapidly at the onset of puberty and decreases rapidly after age 50 (to 20–50% of peak level by age 80). Recent estimates show that approximately 13 million men in the United States experience testosterone deficiency and less than 10% receive treatment for the condition.

Studies also have shown that men with obesity, diabetes, or hypertension may be twice as likely to have low testosterone levels.

Types and Causes

Testosterone deficiency (hypogonadism) may be present at birth (congenital) or may develop later (acquired). It is classified by the location of its cause along the hypothalamic-pituitary-gonadal axis:

* Primary, disruption in the testicles
* Secondary, disruption in the pituitary
* Tertiary, disruption in the hypothalamus

The most common congenital cause is Klinefelter's syndrome. This condition, which is caused by an extra X chromosome, results in infertility, sparse facial and body hair, abnormal breast enlargement (gynecomastia), and small testes.

Congenital hormonal disorders such as leutenizing hormone-releasing hormone (LHRH) deficiency and gonadotropin-releasing hormone (GnRH) deficiency (e.g., Kallmann's syndrome) also may cause testosterone deficiency.

Other congenital causes include absence of the testes (anorchism; also may be acquired) and failure of the testicles to descend into the scrotum (cryptorchidism).

Acquired causes of testosterone deficiency include the following:

* Chemotherapy
* Damage occurring during surgery involving the pituitary gland, hypothalamus, or testes
* Glandular malformation
* Head trauma that affects the hypothalamus
* Infection (e.g., meningitis, syphilis, mumps)
* Isolated LH deficiency (e.g., fertile eunuch syndrome)
* Radiation
* Testicular trauma
* Tumors of the pituitary gland, hypothalamus, or testicles

Signs and Symptoms

Signs depend on the age of onset and the duration of hormonal deficiency. Congenital testosterone deficiency is generally characterized by underdeveloped genitalia (testes that do not descend into the scrotum) and, occasionally, undeterminable genitalia. Acquired testosterone deficiency that develops near puberty can result in enlargement of breast tissue (gynecomastia), sparse or absent pubic and body hair, and underdeveloped penis, testes, and muscle. Adult men may experience diminished libido, erectile dysfunction, muscle weakness, loss of body hair, depression, and other mood disorders.

Use the Testosterone Deficiency Health Quiz to evaluate your symptoms.

Complications
Testosterone deficiency has been linked to muscle weakness and osteoporosis. In one study, proximal and distal muscle weakness was detected in 68% of men with primary or secondary hypogonadism. Spinal, trabecular, and radial cortical bone density may also be significantly reduced in testosterone-deficient men. Thirty percent of men with spinal osteoporosis have long-standing testosterone deficiency, and one-third of men have subnormal bone density that puts them at risk for fracture.

TJ Cline

The forgotten symptoms of low testosterone levels...

Are you having a hard time building new muscle? Do you suffer from low sex drive, constant tiredness, depression, or a loss of strength? If so, low testosterone levels could be the problem.

Many think of low testosterone as something that just affects older men. However, men in their 30's and 40's also fall prey to low testosterone counts. According to the FDA, more than four million men suffer from low testosterone levels. Yet, 95 out of 100 men fail to seek treatment — often because they just accept the symptoms as a "normal" part of getting older.
Low testosterone levels

Testosterone is produced mainly in the Leydig cells in the male testes, and in smaller amounts by the adrenal gland near the kidneys. In women, where production is about one-tenth the total of males, roughly one-half comes from the ovaries. For men, the normal level of testosterone in the bloodstream is between 350 and 1230 nanograms per deciliter.

The production of testosterone increases rapidly at the onset of puberty. Once you reach middle age, however, testosterone levels begin to drop by about one percent each year. In the short-term, this might not sound like much. By the time you reach your 70's and 80's, this constant decline increases the risk of obesity, brittle bones, muscle loss and impotence. Very low testosterone levels can also increase your risk of dying from a heart attack.

Although it's considered as a male hormone, women need testosterone too. Despite the fact they only produce a small amount, testosterone helps women maintain the strength of muscle and bone. After the menopause, testosterone levels drop. Estrogen replacement therapy can also reduce testosterone levels, leaving some postmenopausal women concerned about a lack of energy and libido.

Testosterone is a hormone that's also very important for people wanting to shed fat while preserving (or even gaining) lean muscle. In fact, hormones such as testosterone are one reason why you can lose weight on the scales without being able to shift the fat that seems to be glued to your stomach.

Think of a hormone like the remote control for your television. In much the same way that you change the channel using the remote control, hormones can change the way your fat cells respond to the food you eat.

Your body has billions of these tiny fat cells. They expand to many times their original size in order to store fat. They also shrink when they release stored fat. Fat cells respond to hormones in one of two ways, depending on whether the signal is lipogenic or lipolytic.

The term lipo means fat, while lysis means breakdown. So, a lipolytic (pronounced lip-o-lit-ik) hormone increases the number of fat calories burned for energy. Hormones that promote fat storage, on the other hand, are known as lipogenic (pronounced lie-po-jen-ik). In other words, lipogenic hormones promote fat storage.
Fat loss

Testosterone affects fat loss in one of two ways [2]. Just like a car, your fat cells have a series of brakes and accelerators. The parts of a fat cell that accelerate the release of fat are called beta-receptors. The parts of a fat cell that put the brakes on fat loss are known as alpha- receptors.

The distribution of brakes and accelerators on each fat cell is one reason why certain parts of your body shed fat faster than others. Women, for example, often have a hard time losing fat from their hips. That's because the fat cells in that area have a higher ratio of alpha- to beta-receptors.

If a fat cell has more beta-receptors, it will release stored fat more quickly than one with fewer beta-receptors. That's where testosterone appears to help. By increasing the number of beta-receptors, testosterone makes it easier to lose stored fat.

What's more, testosterone can also limit the storage of fat. When fat cells are exposed to testosterone in a test tube, the activity of lipoprotein lipase — an enzyme that promotes fat storage — is dramatically reduced.

To see whether the same thing happens in the human body, researchers from Sweden gave a group of overweight older men supplemental testosterone (in the form of a pill or an injection) for six weeks [7]. When it was measured after just one week, lipoprotein lipase activity in abdominal fat tissue dropped. Even more dramatic changes were seen six weeks later. Waist size also dropped in 9 of the 11 men.

Further research confirms the positive effect of testosterone on body composition in older men [5]. The men were aged between 65 and 87. All had low levels of free testosterone, and were treated with either transdermal testosterone (two 2.5 milligram patches per day) or fake patches containing no testosterone.

After 12 months, free testosterone levels in the group using the patches rose by 75%. There was no change in the group given the fake patches. Subjects using the testosterone patches also lost fat, with the average body fat percentage dropping from 26.3% to 24.6%.

A long-term study also confirms that men with low testosterone levels are more likely to develop a pot belly [6]. More than 100 Japanese-American men took part in the research. A number of measurements, including total body fat and testosterone levels, were taken at the start of the study. The same measurements were taken again seven years later. Body fat increased to a greater extent in the men starting the study with low testosterone levels.

The link between hormones and body fat applies to women as well as men. Specifically, researchers from Yale have uncovered a link between a hormone known as cortisol and abdominal fat in otherwise slender women [4]. In other words, women who secrete more cortisol in response to stress also have more abdominal fat.
Testing

While a blood test is one of the most common ways to measure testosterone levels, there are several less invasive methods currently available. For instance, some research shows that analyzing saliva is an accurate way to test for low testosterone levels.

Testosterone travels around your bloodstream in two forms — free testosterone or bound testosterone. Roughly two percent of total testosterone is made up of free testosterone, which is the most "active" form. The rest is attached to sex hormone-binding globulin (known as SHBG) and other proteins [3].

In aging men, it's possible for total testosterone to appear normal, while free testosterone is actually low. If you do get your testosterone levels measured, make sure to ask for a reading of both total and free testosterone.

While a blood or saliva test is a more accurate way of establishing your levels of testosterone, you can also use The Saint Louis University Androgen Deficiency in Aging Men (ADAM) Questionnaire. Dr. John Morley, a researcher with the Saint Louis University School of Medicine, developed the self-screening tool to help identify symptoms of low testosterone in men. Choose the responses below that best describe how you have been feeling.

1. Do you have a decrease in libido (sex drive)?
2. Do you have a lack of energy?
3. Do you have a decrease in strength and/or endurance?
4. Have you lost height?
5. Have you noticed a decreased "enjoyment of life"?
6. Are you sad and/or grumpy?
7. Are your erections less strong?
8. Have you noticed a deterioration in your ability to play sports?
9. Are you falling asleep after dinner?
10. Has there been a recent deterioration in your work performance?

If you answer yes to question one or seven, or at least three of the other questions you may have low testosterone levels.
Mood

Another common sign of low testosterone is a change in mood and behavior. You find it very easy to get angry at trivial incidents. Things you used to enjoy now seem like chores. Life no longer seems to be an endless stream of possibilities.

When men who cannot produce testosterone come off hormone replacement therapy, they become irritable and depressed. Their mood improves when they resume treatment.

In fact, some researchers think that low testosterone levels are one reason why some men become grumpy, nervous and irritable as they age. Stress can also cause men of any age to experience a drop in testosterone levels.

The reason is that certain regions of your brain are "loaded" with receptors for testosterone. In fact, men with depression have free testosterone levels almost 20% lower than normal [1]. In contrast, high levels of testosterone lift your mood, giving you a feeling of well-being.
The bottom line

There are many different symptoms of low testosterone levels. Many men experience problems with their love life, ranging from occasional difficulties getting an erection to a complete loss of interest in sex.

If you do have a blood test, remember that testosterone levels are generally higher in the morning and lower in the evening. However, the degree to which testosterone levels vary during the day is reduced as you age. There are also peaks and troughs during the year. Testosterone levels reach a high during June and July, and drop during winter and early spring [8].


The best natural ways to raise your testosterone levels (18 pages)
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Click here to learn more about this exciting special report

References
1. Barrett-Connor, E., Von Muhlen, D.G., & Kritz-Silverstein, D. (1999). Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. Journal of Clinical Endocrinology and Metabolism, 84, 573-577
2. De Pergola, G. (2000). The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. International Journal of Obesity and Related Metabolic Disorders, 24, S59-63
3. Dunn, J.F., Nisula, B.C. & Rodbard, D. (1981). Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. Journal of Clinical Endocrinology and Metabolism, 53, 58-68
4. Epel, E.S., McEwen, B., Seeman, T., Matthews, K., Castellazzo, G., Brownell, K.D., Bell, J., & Ickovics, J.R. (2000). Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosomatic Medicine, 62, 623-632
5. Kenny, A.M., Prestwood, K.M., Gruman, C.A., Marcello, K.M, & Raisz, L.G. (2001). Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. Journal of Gerontology, 56, M266-272
6. Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491
7. Rebuffe-Scrive, M., Marin, P., & Bjorntorp, P. (1991). Effect of testosterone on abdominal adipose tissue in men. International Journal of Obesity, 15, 791-795
8. Andersson, A.M., Carlsen, E., Petersen, J.H., & Skakkebaek, N.E. (2003). Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period: possible effects of seasons. Journal of Clinical Endocrinology and Metabolism, 88, 932-937

FishOrCutBait

Nice post Dr. E. I didnt know that test. and fat loss were connected.

I believe in Jesus.

"tried and true theory on one's self is probably the only non-biased proof that something works for someone." - juggernaut

Tough Old Man

Nice read Dr. E

juggernaut

where the hell do i click for special report?

alexvega

well all the information is good and truth.


but letme share with u ll my case
when i was tenager, i got surgery for one testis.

but my life go well. my muscle are good. my sex drive soso because my jb is tiring, but if u are worried just for the muscle rob. just check my pictures, may be i´m not Doriant .or Ronie. but you can see just with one eye.

AusBB

Great Post. Looks like I will be needing some test then ;-)

Aus BB
Aus Bodybuilding Forum, Home of Australian Bodybuilding

gococksDJS

speaka da engrish...

min0 lee

Great post but wheres the rest?

TJ Cline

The links didnt transfer....I will have to go and try to find the origional page...

BulkMeUp

yeah. Thats the part i was waiting for!

min0 lee

Damn cliffhangers

TJ Cline

http://www.urologychannel.com/testos...cy/index.shtml
Here is the link if you want to take the test or look at related material.

min0 lee

Typical of Foreman, he gets you all worked up then he leaves you hanging.

TJ Cline

Happy now bitches???
http://www.urologychannel.com/testos...cy/index.shtml

TJ Cline

I'll work you up then take you to paradise baby/dude

BulkMeUp

Maybe this is a thread i shoulda stayed out of!

Prince

If you're going to copy/paste an article like that you should post the link and the author of it.

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juggernaut

alexvega

idont care tomatasos jajajajajjajj

juggernaut

hey i resent that remark-I am not a bitch...more like a motherfucker.