Estrogenic Activity: none Progestational Activity: moderate
Methylhydroxynandrolone, or MHN for short, is a potent derivative of the anabolic steroid nandrolone. It differs from this base steroid structurally in two ways. First, it has been c-17alpha alkylated (methylated), a modification that allows this steroid to be orally active. Next, an additional hydroxyl group has been added at its 4 position, similar to hydroxytestosterone. Together these two alterations have created a potent orally active and non-aromatizable anabolic steroid, with a profile somewhat similar to that of Winstrol or Anavar - a primarily anabolic agent with no discernible estrogenic activity. This anabolic was investigated back in the 1960's, and to spite its effective nature was never released as a prescription drug. Its properties make it of obvious interest as a designer steroid, and I would not be surprised if numerous athletes have used it for this purpose over the years. However, since we have not seen a MHN scandal in the media, this remains a matter for speculation.
Although this steroid is a nandrolone derivative, it acts quite differently from its chemical parent. For starters, while nandrolone is a relatively mild steroid, MHN is an exceedingly potent synthetic agent.
According to assay results published in Hormonal Steroids (Academic Press, 1964), methylhydroxynandrolone is 13 times more potent than methyltestosterone. This is clearly something of interest for this makes MHN stronger than any prescription steroid known currently. MHN is also quite potent as an androgen, behaving more like trenbolone than nandrolone in this regard. The relative androgenicity of this steroid is likely intensified by its 4-hydroxyl group, a modification that prevents its 5-alpha reduction to weaker "dihydro" metabolites in the skin, scalp and prostate. MHN cannot interact with the reductase enzyme, therefore, it retains its original level of potency in these same tissues. This steroid is still technically more of an "anabolic" than an "androgen", but it is definitely not the mild nandrolone you are familiar with.
Due to its displaying such a high level of milligram for milligram potency, the typical effective daily dosage for men is going to be comparatively much lower than one would expect with other agents. For example, while Dianabol might warrant using 25-35mg daily to notice a pronounced benefit, methylhydroxynandrolone users will likely be working in the range of only 5-15mg per day. At this level MHN should provide very solid gains in muscle mass and strength, with no water retention or increased fat deposition. If anything the user is likely to lose body fat at the same time, one of the reasons why athletes will often spend the extra money on an anabolic like Winstrol, instead of simply taking cheap testosterone or Dbol. This drug is also versatile for stacking, and mixes well with most other anabolics (for cutting) or androgenic (for bulking phases). Women should probably stay away from this steroid altogether, and instead opt for an agent known to be less androgenic (and friendlier to women). Something like Primobolan, Winstrol or Anavar would be a much better choice than MHN, with less chance for permanent masculine side effects.
Methylhydroxynandrolone is not available as a prescription agent at this time, in any part of the world. This agent was merely investigated as a drug, and never sold as one. It has appeared on the U.S. supplement market very recently, sold legally and openly as a nutritional product. This was due primarily to the fact that it was never regulated as a drug in this country, and, barring a direct listing on the 1992 steroid law, could not be covered by it. MHN has since been included in the most recent expansion of our nation's steroid laws, and is formally a controlled anabolic steroid in the U.S. as of January 20, 2005. Possession of this agent after this date carries all the same legal risks and consequences as other popular and illegal steroids.