HCG and nolva together?

Tha Don · 12-10-2005, 12:40 PM

Quote:

Tamoxifen Blocks HCG Induced Leydig Cell Desensitization

HCG induced testicular desensitization seems to be a hot topic. There are a number of studies showing that concomitant use of Nolvadex ameliorates this. The first abstract suggests that HCG at least partially blocks the conversion of 17 alpha-hydroxyprogesterone (17 OHP), a testosterone precursor, to testosterone. This effect is suppressed by Nolvadex.

The second abstract seems to indicate that estrogen may not be the only culprit, since Nolvadex plus HCG does not increase T levels any more than HCG alone, even though the combination reduces desensitization.

Since we are trying to avoid this desensitization so when we quit the HCG our testes respond to our endogenous LH, it makes sense to always use nolvadex with HCG to at least help the problem, if not solve it completely.

J Clin Endocrinol Metab 1980 Nov;51(5):1026-9

from this, should we assume that nolva should be taken with our HCG shots?

**Pirate!** · 12-10-2005, 01:44 PM

Quote:

Originally Posted by young d

from this, should we assume that nolva should be taken with our HCG shots?

It appears to be helpful when taking doses of hcg that might otherwise cause desensitization. I doubt small (500 iu or less) would cause any desensitization, unless done too frequently.

brogers · 12-10-2005, 07:31 PM

I was under the impression you become desensitized to HCG, not the your endogenous LH.

**Pirate!** · 12-10-2005, 09:38 PM

Quote:

Originally Posted by brogers

I was under the impression you become desensitized to HCG, not the your endogenous LH.

Too much HCG can cause your testes to have less LH receptors, which makes a given amount of endogenous LH less effective.

12-10-2005, 07:31 PM	#3
brogers Registered User Join Date: Jul 2004 Posts: 1,253	I was under the impression you become desensitized to HCG, not the your endogenous LH.
brogers Registered User Join Date: Jul 2004 Posts: 1,253

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