Thread: Igf-1

Originally Posted by tommyboy11

Hey guys jus had a question, went lookin through threads but couldnt find much info, what do you guys think of IGF-1 i was thinkin of runnin it possibly sometime into the future and see some sites sellin it. I would appreciate any feedback you guys have on it, thanks

I've heard a lot of good things and very little bad. Apparently the biggest side is if you dose too high, you can go hypoglycemic (sp?), so make sure you have some carbs right after. Effective doses are as low as 30-40mcg a day.

cool thanks alot man, def gonna check this stuff out

Expensive

Originally Posted by dg806

Expensive

Depends on how you look at it. Figure it at $120 a kit which will last about 25 days, which is about where diminishing returns begin. Contrast that to HGH which you run for six months, and you're saving a ton of cash.

what does it do?

Originally Posted by musclepump

Depends on how you look at it. Figure it at $120 a kit which will last about 25 days, which is about where diminishing returns begin. Contrast that to HGH which you run for six months, and you're saving a ton of cash.

LOL, how you figure??? Seeing where real gear at half that cost will give you many more times the gains.

My experience with IGF-1 has been disapointing.
I ran up to 100mg ed with not much result.
Tried 2 different sources and used both the powder form and the premix.

I know several people that reports good results but many also report no result so it seems to be a hit or miss.

Originally Posted by dg806

LOL, how you figure??? Seeing where real gear at half that cost will give you many more times the gains.

Hi Genius,

Because as you noticed (if you opened those steroid-swollen eyes, ya fucking juicer!) I was comparing it to Human Growth Hormone, not Anabolic Steroids.

Originally Posted by Heimir

My experience with IGF-1 has been disapointing.
I ran up to 100mg ed with not much result.
Tried 2 different sources and used both the powder form and the premix.

I know several people that reports good results but many also report no result so it seems to be a hit or miss.

How did you run it--did you shoot it all at once or divide your doses pre and post workout?

Originally Posted by musclepump

How did you run it--did you shoot it all at once or divide your doses pre and post workout?

Tried it different ways.
40mcg first thing in the morning and 40mcg post workout.
40mcg pre workout and 40 mcg post workout.
80mcg post workout.

Really did not do much for me.

Originally Posted by Heimir

Tried it different ways.
40mcg first thing in the morning and 40mcg post workout.
40mcg pre workout and 40 mcg post workout.
80mcg post workout.

Really did not do much for me.

Bummer.

I like it for cutting. It's great for shuttling glucose over an extended period. It won't do much for mass or strength, though. You will feel like you have arthritis.

Originally Posted by Pirate!

I like it for cutting. It's great for shuttling glucose over an extended period. It won't do much for mass or strength, though. You will feel like you have arthritis.

How were your pumps on IGF-1? I've heard a lot of feedback that pumps can get painfully intense.

Originally Posted by musclepump

Hi Genius,

Because as you noticed (if you opened those steroid-swollen eyes, ya fucking juicer!) I was comparing it to Human Growth Hormone, not Anabolic Steroids.

(dg grabs his .40 to shoot mp between the eyes!)
Both are expensive, at least to me. I couldn't afford either one the way it would need to be used.

Originally Posted by musclepump

How were your pumps on IGF-1? I've heard a lot of feedback that pumps can get painfully intense.

They aren't problematic for me at any dose. Maybe if I was using gear, they could get out of hand.

Originally Posted by Pirate!

They aren't problematic for me at any dose. Maybe if I was using gear, they could get out of hand.

How about headaches? I've heard those are common as well on IGF-1

IGF didn't do anything for me either, but I only tried it once. If you try it twice and it doesn't do anything for you, leave it be.

Friend of mine liked it at 60mcg daily, 40mcg he didn't notice much.

Originally Posted by Mudge

IGF didn't do anything for me either, but I only tried it once. If you try it twice and it doesn't do anything for you, leave it be.

Friend of mine liked it at 60mcg daily, 40mcg he didn't notice much.

I'm at 40mcg and so far the only thing I notice is a splitting headache that I've had every minute of the day since about twenty minutes after my first pin.

I didn't have any of those issues thankfully.

Originally Posted by Mudge

I didn't have any of those issues thankfully.

I envy you.

Doesn't much matter when I got no gains from it.

Originally Posted by Mudge

Doesn't much matter when I got no gains from it.

Maybe yours was bunk.

Or cooked, dunno. Some people just dont respond brother, and I'm famous for not responding. Creatine has never worked for me, no delivery system I've yet tried.

Your IGF-1 probably didn't work because it wasn't renatured correctly. Other forums have posted nice semi-soft science threads that describe its reconstitution from lyophylized (free dried) powder. You need 100 mM acetic acid buffer acid to protonate the surface enough of this relatively small peptide to get 'untangled" from the protein glue it forms once water hit the concentrated mass.

Plus, you got fuckchops who think they know what they're doing when they use a peptide synthesizer. Don't purify the endproduct, you get these short shit sequences that are competitive binders for the same active sites as the long from IGF-1, 'cept that they don't work. Plus, your product did sit in not so good conditions in a hot environment before you made it up to use.

My guess: dirty product of questionable quality, improper reconstitution and potentially thermal damage, in that order. The lack of effective product would support the observation of a lack of the commonly reported headache side effect Why do you get headaches from IGF-1? It interacts with pro-inflammatory agents (cytokines and prostanoids) in various cells, including the muscles of the neck and head, and in brain, where mild neuralgia can be induced by inflammation at the base of the brain/spinal chord junction.

How do I know this? I worked in molecualr biology and protein biochemisry for many years.

The reason you aren't a creatine responder is that you haven't the proper ion control in your cells; that can be remedied. Plus, you may have been using a creatine form (monohydrate) that dimerized(forms polymers that are too big to be effectively transported into intestinal lumen) during commercial process drying (its sold as anhydrous crystalline form). I'd put my money on the dimerized form and also your aquaporin status, Mudge.

Originally Posted by Trouble

Your IGF-1 probably didn't work because it wasn't renatured correctly. Other forums have posted nice semi-soft science threads that describe its reconstitution from lyophylized (free dried) powder. You need 100 mM acetic acid buffer acid to protonate the surface enough of this relatively small peptide to get 'untangled" from the protein glue it forms once water hit the concentrated mass.

Plus, you got fuckchops who think they know what they're doing when they use a peptide synthesizer. Don't purify the endproduct, you get these short shit sequences that are competitive binders for the same active sites as the long from IGF-1, 'cept that they don't work. Plus, your product did sit in not so good conditions in a hot environment before you made it up to use.

My guess: dirty product of questionable quality, improper reconstitution and potentially thermal damage, in that order. The lack of effective product would support the observation of a lack of the commonly reported headache side effect Why do you get headaches from IGF-1? It interacts with pro-inflammatory agents (cytokines and prostanoids) in various cells, including the muscles of the neck and head, and in brain, where mild neuralgia can be induced by inflammation at the base of the brain/spinal chord junction.

How do I know this? I worked in molecualr biology and protein biochemisry for many years.

The reason you aren't a creatine responder is that you haven't the proper ion control in your cells; that can be remedied. Plus, you may have been using a creatine form (monohydrate) that dimerized(forms polymers that are too big to be effectively transported into intestinal lumen) during commercial process drying (its sold as anhydrous crystalline form). I'd put my money on the dimerized form and also your aquaporin status, Mudge.

The headache comes from

Well my IGF-1 must definitely be good, because my head is fucking killing me.

You mentioned that you can "remedy" yourself if you're not a Creatine responder; like Mudge, I'm not. What's the remedy?

A major action of cellular regulation is maintenance of physiologically important conditions. That includes ion concentration, and that means cellular hydration and the movement of ions, important energy factors, and water in and out of cells. That ion regulation is tightly coupled to both glycogen (glucose storage) and creatine processining. Insulin controls the expression of a group of membrane channel proteins that control water and ion movement in and out of cells. Insulin insensitivity means you don't do this correctly, and you pay a price in the efficiency of cellular function and repair.

Make sense?

Now, if your question was: how do you reduce the sides from the IGF-1 upregulation of PGs and cytokines, then you need to control both COX1 and COX2. These are cyclo-oxygenase enzymes in the prostaglandin biosynthesis pathways, first is constiutive = always made, second is induced, made on demand as is necessary. First is always around, second is turned on by IGF-1 and many other nuclear receptor transcription factors.

I would use both cayenne pepper extract and also turmeric extract, twice daily with food, both are dirt cheap, reliable supplements that you can buy at WallyWorld (Walmart).

They are potent nuclear receptor regulators. You should also be using:
K-RALA, vitamin E and omega-3 fats (fish oils). Each of them play a role in proper inflammation (prostaglandin) control.

Musclepump,

I've not heard of anyone having headaches like that from IGF. You may have bad shit, bro.

Just an update... headaches have subsided... thank the good Lord!