Thread: Exemestane

I've been reading about the anti E exemestane. Now it says that exemestane is an irreversible, steroidal aromatase inactivator. What do thay mean by "irreversable". does that mean that it will permanently bind to the aromatase enzyme or forever stop the conversion of estrogens. and if that is true wouldn't that be unhealthy since you want all your hormones/enzymes to return to their natural state/balance after a cycle?

Essentially, it means that the enzyme can not be repaired. Therefore, the body must produce more enzyme to again resume normal function. Compare this with Anastrozole, which binds reversibly. In that case, more estrogen can displace the anastrozole and again bind to the enzyme.