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heavyiron
12-22-2010, 06:37 PM
Winstrol

(stanozolol)

Winstrol - Stanozolol is a very commonly used anabolic steroid for cutting cycles. While many people will attempt to use Dianabol or even Anadrol for cutting cycles, I´ve really never heard of anyone using Stanozolol for anything except a cutting cycle. It´s a bit of a one-trick-pony in this respect. Let me repeat that: Stanozolol is a cutting drug. Not many people will argue for its use in a bulking cycle. It´s certainly not a very effective compound for treating anemia (1) and thus, one could rightly assume that its role in bulking cycles is very limited. One novel use for Winstrol in any cycle (perhaps even bulking) would be to use it at a very limited dose, in order to lower SHBG. (2) One of the properties of Winstrol is it´s profound ability to lower SHBG much more than other steroids. A dose of .2mg/kg lowered SHBG significantly, which would in turn, raise the amount of free testosterone circulating in the body. As with 99% of steroids, however, it´s important to note that suppression of your natural hormonal levels will occur (though perhaps not to the extent that it will with many other steroids).(10) As with running virtually any compound, testosterone supplementation (i.e. running test in a cycle containing Winstrol) is warranted to avoid possible sexual dysfunction.

Winstrol & Stanozol Side Effects

Adding it to a heavy bulking cycle could be problematic, as Stanozolol is a 17aa compound, meaning that it´s been altered to endure the first pass through your liver without being destroyed. This makes it an orally active compound; so many people choose to take the pills which are available from both legitimate pharmaceutical companies as well as Underground Labs. Unfortunately, since it is 17aa, it is also liver toxic& in fact; Stanozolol has one of the worst hepatoxicity (mg for mg) of any steroid. This is the reason its addition to a bulking cycle could be problematic; generally a bulking cycle will be very heavy, dosage wise as well as toxicity-wise. It also has undesirable results on Cholesterol, and a mere 6mgs/day of Stanozolol can lower HDL by 33% and raise LDL by 29% (3). Cardiac Hypertrophy, even at lower doses could be a concern with Winstrol as well (4) Thus, many people limit their intake of Stanozolol to precontest or Summer-cutting types of cycles. It´s generally accepted that due to the toxicity issues of Stanozolol, its use should be limited to 6 weeks & as with anything though, many people have run it for up to 12 weeks with no problems. Another great feature of Winstrol is that it does not aromatize, meaning it does not convert into any estrogen in the body.

Winstrol & Stanozol Use Effects

I ran Winstrol for about 3 months (12 weeks) at a dose of 100mgs Every Other Day (along with Test prop at 125mgs, every other day) and I suffered no ill-effects. My joints felt fine, and I can say that the only thing which was undesirable about that cycle was the injection pain. Generally, people report a "dry" and less lubricated feeling in their joints when on this drug (fluid retention is nil with Stanozolol), and also a "dry" overall look as regards contest prep. This could be due to a sort of "reverse-osmotic" effect...of course this is speculation, but people do look "dryer" on Winnie, and some even look dryer in the site they inject(more on this later). There are many conflicting reports on tendon strength and Stanozolol, even in medical journals. Some reports state that it weakens tendons, others that it strengthens them (and some speculation on the internet among many "guru´s" is that it strengthens them unevenly, leading to possible injury). For this reason, it may be best for athletes in explosive or high-impact sports to stay away from this drug. It has certainly been shown to be beneficial in some bone ailments induced by glucocorticoid induced stress (5) as well as having collagen producing properties (11), but with all of the anecdotal problems athletes have suffered with their joints while on Stanozolol, I simply can not recommend it with confidence to strength/speed athletes. I can say that personally, it was an effective compound for me and did not cause joint duress, but I can do without the discomfort of the shots, and have found other DHT based compounds to be far more effective (Masteron springs to mind). Those who find themselves more prone to the joint issues will usually counter-act this side effect by either taking a joint support (usually high in glucosamine, MSM, Flax oil, ect~), or by taking a compound such as Deca which is infamous for joint lubrication.

As previously stated, this compound is unique, as it is available in both an oral form as well as an injectable form. Both forms contain the exact same compound, but injecting this compound (and yes, you can drink the injectable version, and no you shouldn´t) is superior to ingesting it orally in terms of nitrogen retention (6), and thus one would also imagine, for overall anabolism. Injecting it also has the advantage of avoiding the "first pass" through your liver, and thus places your liver under less stress. Dosing is identical for both the oral and injectable versions, at around 50-100mg per day. Stanozol injections are known for being mildly painful.

Stanozolol (Winstrol) and Women

Stanozolol is also one of the few compounds that women can take safely, as it´s anabolic:androgenic ratio is quite skewed towards anabolism. It´s generally accepted that women can tolerate around 5-10mgs a day of this compound. Men, on the other hand can dose themselves in the .5-1.5mg/kg range. I find 100mgs injected every other Day to be sufficient, but of course, even with the injectable form, every day dosing is optimal. I tend to favor DHT based compounds, and have enjoyed great success with a Winstrol/Masteron/Testosterone cycle, but I suspect that replacing the Masteron in that cycle with Trenbolone would prove more beneficial for most bodybuilders seeking to get ripped.

Although the anabolic ratio of this product is very high as compared to its androgenic actions, not many people report huge weight gains off of Stanozolol. Also, interestingly, it has a relatively weak AR binding ability (7), which is quite unusual for a "cutting" steroid. Many of the effects of this drug, as relates to building muscle, are probably from its very high protein synthesizing ability (6) (8). In addition, since this compound is derived from DHT, it tends to promote a very nice, "quality" look to the user´s muscles, with little or no water retention. Winstrol does not aromatize at any rate and has even been speculated to have anti-progestenic properties (in at least some cases, where it may "block" that receptor) (9). If one were to run ancillary compounds with Stanozolol, perhaps Tamoxifen would be appropriate for it´s beneficial effects on blood lipids, but an anti-estrogen (in it´s classic sense) would be unwarranted; proper post cycle therapy is still needed, though.

Typical Sides (In Women) may include interrupted periods, irregular menstrual sides, acne, oily skin and/or hairlosss, a 'cracking' or a deepening voice, and dry joints.

Winstrol on the market (couldnt think of a better sub-title lol) -> should be seperated from the "winny in women" section.

Most underground labs produce Winstrol at very reasonable prices, in both an oral as well as injectable form. Unfortunately, production value differs vastly due to the varying size of the Stanozolol powder used to make the injectable version; the finer the powder, the smaller gauge needle it will fit through, and the easier the injection will be. Of course the opposite is also true& In any case, you should be paying under $100 for a 10ml bottle of 100mg/ml concentration, and roughly the same for 100 or so 10mg tablets.

Winstrol Profile

Stanozolol
[17beta-Hydroxy-17-methyl-5alpha-androstano[3,2-c]pyrazole]
Molecular Weight: 344.5392
Molecular Formula: C22H36N2O
Melting Point:N/A
Manufacturer: (Originally) Sterling
Release Date:1962
Effective Dose(men): 50-100mgs/day
Effective Dose (women): 5-15mgs/day
Active Life:8hours
Detection Time:3 weeks (oral) to 9 weeks (injectable)
Androgenic/Anabolic Ratio:30:320

References:



Trop Doct. 2004 Jul;34(3):149-52.
J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200
JAMA. 1989 Feb 24;261(8):1165-8.
J Steroid Biochem Mol Biol. 2005 Jan;93(1):43-8. Epub 2005 Jan 25.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Nov;23(11):1117-20.
Can J Vet Res. 2000 Oct;64(4):246-8.
Endocrinology. 1984 Jun;114(6):2100-6.
J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22
Agents Actions. 1994 Mar;41(1-2):37-43.
Chemical Muscle Enhancement
J Invest Dermatol. 1998 Dec;111(6):1193-7.

heavyiron
12-22-2010, 06:44 PM
Stimulation of collagen synthesis by the anabolic steroid stanozolol.

Falanga V (http://forums.rxmuscle.com/pubmed?term=%22Falanga%20V%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Greenberg AS (http://forums.rxmuscle.com/pubmed?term=%22Greenberg%20AS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Zhou L (http://forums.rxmuscle.com/pubmed?term=%22Zhou%20L%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Ochoa SM (http://forums.rxmuscle.com/pubmed?term=%22Ochoa%20SM%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Roberts AB (http://forums.rxmuscle.com/pubmed?term=%22Roberts%20AB%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Falabella A (http://forums.rxmuscle.com/pubmed?term=%22Falabella%20A%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Yamaguchi Y (http://forums.rxmuscle.com/pubmed?term=%22Yamaguchi%20Y%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
University of Miami School of Medicine, Department of Dermatology, Miami Veterans Affairs Medical Center, Florida, USA.

There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear. In this report, we measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone. The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.

PMID: 9856839 [PubMed - indexed for MEDLINE]

heavyiron
12-22-2010, 06:44 PM
The effect of stanozolol on 15nitrogen retention in the dog.

Olson ME (http://forums.rxmuscle.com/pubmed?term=%22Olson%20ME%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Morck DW (http://forums.rxmuscle.com/pubmed?term=%22Morck%20DW%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract), Quinn KB (http://forums.rxmuscle.com/pubmed?term=%22Quinn%20KB%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVAbstract).
Animal Health Unit and Gastrointestinal Sciences, University of Calgary, Alberta. molson@ucalgary.ca (molson@ucalgary.ca)

The objective of the study was to determine the influence of either oral or intramuscular administration of stanozolol on nitrogen retention in dogs by using a non-invasive 15N-amino acid tracer technique. Ten healthy, intact, adult male sled dogs received either stanozolol tablets, 2 mg/dog PO, q12h, for 25 days (Group 1, n = 5) or an intramuscular injection of 25 mg of stanozolol on Days 7, 14, 21, and 28 (Group 2, n = 5). A 15N amino acid (5.27 mmol) was infused intravenously into each dog on Day 0 (before stanozolol treatment) and on Day 31 (after stanozolol treatment). Urine was collected by catheterization from each animal 3 times daily for 3 consecutive days. The 15N-urea enrichment in urine was determined by high-resolution mass spectrometry and the total amount of urea in the urine was determined. Both oral and injectable stanozolol resulted in significant (P < 0.05) increases in amino acid nitrogen retention compared to pretreatment values. Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%. The response to intramuscular administration was significantly greater than the response to the oral dosing regime. Stanozolol increases amino acid nitrogen retention in dogs, as has been previously observed in rats. This action of stanozolol may be beneficial in dogs under stress of surgical trauma and chronic disease.

PMID: 11041505 [PubMed - indexed for MEDLINE]

TwisT
12-22-2010, 07:40 PM
Prolonged treatment with (the AAS) stanozolol increases antioxidant defences in rat skeletal muscle

Delgado J (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Delgado%20J%22%5BAuthor%5D), Saborido A (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Saborido%20A%22%5BAuthor%5D), Megas A (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Meg%C3%ADas%20A%22%5BAuthor%5D).
Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, 28040 Madrid, Spain.
Abstract

Testosterone and its synthetic derivatives anabolic-androgenic steroids have been shown to increase skeletal muscle work capacity and fatigue resistance, but the molecular basis for these effects remains uncertain. Since muscle performance has been related to redox status of exercising muscles, this investigation was aimed at testing whether a treatment with suprapharmacological doses of the anabolic-androgenic steroid stanozolol, (2 mg/kg body weight, 5 days/week, for 8 weeks), either alone or in conjunction with treadmill training (12 weeks), enhanced antioxidant defences in rat muscles. Stanozolol treatment did not modify thiobarbituric acid reactive substances and glutathione content in soleus and extensor digitorum longus (EDL) homogenates. In soleus from sedentary rats, superoxide dismutase and glutathione reductase activities were increased by 25% (P < 0.05) and by 40% (P < 0.01) after stanozolol administration, whereas catalase and glutathione peroxidase activities were not modified. This response was similar to that induced by training alone. In EDL from sedentary rats, stanozolol increased only superoxide dismutase activity (20%, P < 0.05). In no case, the effects of steroid administration and training were additive. HSP72 levels were up-regulated in soleus (1.5-fold, P < 0.01) and EDL (threefold, P < 0.001) following training but remained unchanged after stanozolol treatment. Endurance capacity, assessed in a treadmill endurance test, was similar for treated and control rats. We conclude that stanozolol treatment increases antioxidant capacity in selected skeletal muscles from sedentary rats. However, the steroid was not effective in improving endurance capacity or enhancing the training effects on muscle antioxidant defence systems.

PMID: 20480277 [PubMed - in process]

sassy69
12-27-2010, 01:24 PM
Women & Winstrol
*Note: * caveat about this is general information & not medical recommendations *

Overview
Winstrol, or "winny", is one of the steroids most commonly suggested for women, (along with anavar and primobolan). Winstrol comes in both oral and water-based injectable form (or as water-based, you can actually drink it). It is attractive to women or recommended for women because it is an oral, it has a relatively short half-life and detection time (i.e. it clears the system relatively quickly, reducing the duration of any undesired sides following completion of a cycle), and promotes lean muscle mass without water retention. It is most commonly viewed as a "cutter" for physique competition. Winstrol is also attractive as it tends to be both cheaper and more readily available than anavar or primobolan. Also because of this, it is less likely to be faked.

Winstrol is often grouped with Anavar as good steroid for "beginners" or those who don't want to go into the more aggressive compounds (i.e. injectables), however, it is more androgenic than anavar and sides are less predictable and more unique to the individual, with the potential of being very androgenic. Because of this, anavar would generally be the better recommendation, but winstrol is seen as a viable alternative.

Typical Use
Winstrol is most commonly used both by men and women, as a cutter during competition prep. It promotes lean, hard muscle mass without water retention. One might see figure competitors running a winstrol-only cycle, or a more advanced physique competitor using it in a stack towards the final weeks of a competition prep. It might also be used, especially in oral form, by someone who wants to "take it to the next level".

Typical Cycle
Oral winstrol:
can be cycled similarly to anavar, as they both have comparable half-lives and detection times and doses.
Dose: 5-15 mg / day - split the dose 1/2 in the AM, 1/2 in the PM
Duration: 8-12 weeks

Injectable winstrol:
Dose: 25 mg E3D
Duration: 8-12 weeks
No taper down or post cycle therapy (PCT) is needed.
If chosen to include in a competition cutting stack, schedule towards the final weeks of prep. It takes about 2 weeks to "show itself".


Typical Sides
- interrupted period / flow - may take a few months for the flow to come back as normal.
- may still experience usual menstrual sides (cramps, bloating, etc.) on your regular menstrual schedule
- mild to aggressive acne
- oily skin / hair
- hairloss
- scratchy throat / cracky or deepening voice
- dry joints

heavyiron
05-05-2011, 09:04 PM
Winstrol (Stanozolol) A Basic Guide By Heavyiron

Stanozolol has a anabolic rating of 320 and an androgenic rating of 30 making it an excellent steroid for promoting muscle growth with zero water retention. Stanozolol cannot aromatize into estrogen so estrogenic side effects like water retention are not a factor. Even the most gyno prone users can use Winstrol without any worry of gynocomastia.

Winstrol is excellent for dieting bodybuilders and is best employed near the end of a cutting cycle to keep the user anabolic but give a dry shredded appearance. Winstrol is also favored by speed athletes like runners, swimmers and even fighters who want to stay in a certain weight class but want to have an anabolic edge.

Winstrol also significantly lowers SHBG even at very low doses in a matter of a few days. This is significant because that equates to more free testosterone. Winstrol stacked with testosterone means more testosterone stays free or active. Some users report increased sex drive when stacking Winstrol with testosterone. Basically Winstrol makes your testosterone work better and it can raise libido.

Administration Men

A good starting dose for performance is 25-50mg Winstrol daily. I prefer to stack Winstrol with testosterone propionate. I also prefer shorter runs of around 3-6 weeks due to liver stress and Winstrol's ability to lower HDL and raise LDL cholesterol like most oral steroids.

Administration Women

A good starting dose for performance is 10mg Winstrol daily for 6-8 weeks. A more adventuresome female may take up to 20mg Winstrol daily, however side effects such as interrupted menstruation, acne, oily skin, hair loss and deepening of the voice will likely increase with dosage.

Not all Winstrol is created equal

Injectable Winstrol is usually a suspension as opposed to a solution. Suspensions have tiny particles that are visible with the naked eye. If left on the shelf for a few days many times the particles will sink to the bottom leaving the clear solvents and water on the top. Depending on the manufacturer, particle sizes vary meaning some Winstrol preparations can clog a 22 gauge needle. Ultra micronized Winstrol can easily pass through a 25 gauge needle making injections more comfortable. Because of the various particle sizes Winstrol may remain active in the blood stream for several days once injected. Basically the solution almost immediately hits the blood stream when injected and then a few days later the solid particles are slowly absorbed by the body. The basis for this was demonstrated in March of 2011 in a pharmacokinetics study done in horses that reported a median terminal half-life of 39 hours with aqueous Testosterone Suspension. Therefore every other day dosing is reasonable with injectable Stanozolol.

http://www.ironmagazineforums.com/attachments/anabolic-steroid-profiles/39217d1326561818-winstrol-stanozolol-updated-winstrol_resize.jpg

Winstrol Base is similar to aqueous Winstrol Suspension however Winstrol Base is technically a solution not a suspension. Winstrol Base contains no visible Winstrol crystals because they are in an oil and solvent solution NOT water. There are no crystals to slowly absorb into the injection site. Therefore when you inject Winstrol Base there is a very rapid increase in blood Winstrol levels that falls off faster than standard aqueous Winstrol suspension. An advantage of Winstrol Base is you may use very small gauge needles to inject it. There are no crystals in Winstrol Base to clog the needle so administering with an insulin syringe is an option.

Can I mix water based Winstrol with oil based steroids?

A common misconception is that oil and water based steroids cannot be injected together. This is absolutely false. You may mix water based Winstrol with any oil based steroid. The picture below is Cypionate and Winstrol together in the same syringe (Winny lava lamp).

http://www.ironmagazineforums.com/attachments/anabolic-steroid-profiles/39216d1326561818-winstrol-stanozolol-updated-oil-winstrol-closeup.jpg

Bacteria and water based steroids (drinking your Winstrol)

Bacteria have an easier time living in water based steroids than in oil based steroids. Water based Winstrol is notorious for causing painful lumps at the injection site and for causing infections and or abscesses. This is because many underground labs improperly assemble steroids not because of the Winstrol itself. I don't recommend injecting UGL water based Winstrol due to the risk for infection unless it's a regulated or trusted lab. I recommend pharmacy grade injectable Winstrol made at high standards or Winstrol base. Because aqueous injectable Winstrol can be ingested orally and because it can cause infections when injected some users drink their injectable Winstrol to avoid infections as gastric acid destroys the bacteria. You may drink your aqueous Winstrol however injecting has been proven to work better mg for mg than oral administration in terms of nitrogen retention. Fair warning though, injectable aqueous Winstrol tastes absolutely awful.

Overall Winstrol is an excellent "cutting" anabolic and also well suited for speed sports. It's the "summer" steroid because it does not promote the watery look that so many other steroids do.

References
Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test.
Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.
The effect of stanozolol on 15nitrogen retention in the dog.
Effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.
An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses.