View Full Version : Proviron and it’s mood altering effects

08-31-2020, 06:47 AM
Proviron has a molecular formula of C20H32O2 and has an active life of eight to twelve hours though its effects can be experienced up to 24 hours. The drug has an anabolic-androgenic ratio of 100-150: 30-40 and can be detected over a period of 5-6 weeks.

One of the biggest advantages associated with use of Proviron is its unique ability to promote the count and quality of sperm and is also indicated to treat serious wellness problems such as low libido and erectile malfunction. The drug is even recommended to male patients struggling with impotency or lack of testosterone. In addition to these advantages, use of Mesterolone is also associated with improved release of luteinizing hormone and follicle-stimulating hormone for stimulating testes so that more testosterone can be produced.

Since it is not a 17 alpha alkylated compound, it can be used for a long period of time. The drug can even enhance potency of testosterone when used in an anabolic steroid cycle with it. The fact that Proviron can attach itself to SHBG (sex hormone-binding globulin) and albumin means that a large percentage of testosterone (free) is made available to conduct anabolic actions. Furthermore, the performance enhancing drug can also be used as an anti-aromatase and this characteristic proves to be beneficial when the drug is stacked with other anabolic steroids and performance enhancing drugs that may convert to estrogen to some extent. Since this steroid can bind to the aromatase enzyme, it does not allow steroids that are made a part of the cycle (with Proviron) to interact with enzymes and lead to formation of estrogens.

The increased level of free testosterone can then be utilized by the body for promoting protein synthesis that in turn stimulates muscle gain. Moreover, the steroid also has the ability to reduce the amount of free estrogen in the body by minimizing estrogen receptors’ ability to bind to estrogen. The drug is medically recommended to individuals suffering with potency disturbances due to androgen-deficiency, easy fatigability, lack of concentration, weak memory, disturbances of libido, depressive moods, general vegetative complaints, irritability and declining physical activity and mental alertness in middle- and old-aged men.

Neurobiology: Mood altering Effects

Testosterone is in-fact a prohormone in the brain; it’s converted into either DHT or oestradiol, to act upon androgen and oestrogen receptors (AR/ER), respectively. This of course causes sexual differentiation of the brain 26. Progesterone can antagonise actions at both AR and ERs in the brain. Oestrogen promotes neurotrophic synthesis, modulates cholinergic and dopaminergic neurotransmitter systems, and protects the brain against stress and inflammation 27. It also elevates serotonin and modulates serotonin receptor distribution. Why? Because oestradiol increases the production of tryptophan hydroxylase, which is the rate limiting step in the synthesis of serotonin from tryptophan, thus increasing serotonin concentrations. Additionally, it inhibits the expression of the serotonin reuptake transporter (SERT) gene and acts as an antagonist at SERT, resulting in promoting the actions of serotonin due to increasing the length of time it remains available within synapses and the interstitial space of the brain 28–30.

Oestradiol also upregulates 5HT2A (a serotonin receptor) in the brain 28. Taken together, these effects will ultimately cause an anti-depressive effect. This is true of the oestradiol that testosterone converts to in the brain of males too. The brain has significant expression of SRD5A (5α-reductase), which converts Testosterone to DHT, thus clearly indicating that there are local, tissue-specific effects of DHT on cognition and mood. We understand that DHT treatment promotes the expression of synaptic plasticity markers and positively modifies synaptic structures. What this means is that DHT promotes good synaptic health, important in preventing diseases such as Alzheimer’s 31. We know that Mesterolone (Proviron) also alleviates depression symptoms in men with less side effects than amitriptyline (tricyclic anti-depressant) 32. This suggests that testosterone and androgens act as central MAOIs too.32


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