Thread: IGF1-Des: Why is it much better then IGF-1 and IGF-1LR3 and how does it work?

Well IGF-1 Des is a lot like your normal IGF1 molecule with the exception that IGF1 has a 70 amino acid chain and IGF-1 Des has only 67. This is not a bad thing, there are purposefully 3 amino acids cleaved off and that is why it has a very low affinity to binding proteins which is a good thing as it makes it about 10X more potent than your normal IGF-1 peptide chain would be in the body.

The half-life of this peptide is still very short, the same as with IGF-1. IGF-1 Des it is MUCH more biologically active, giving much greater results over IGF-1 regardless of the similar active life span per dosing.

This matters to us because IGF-1 play's a major role in cell growth and development of tissues throughout the body and mind of nearly all animals. This goes from muscle-building and tendon-building effects to even neurological building effects. Really just about any role of growth in tissue has IGF-1 connected to it somehow; it is truly an amazing peptide to study.

Here is a very interesting comment showing the promising direction IGF-1 Des is going in the medical field with regards to possible mental enhancement: "This characterization of the acute actions of des-IGF-1 at hippocampal excitatory synapses may provide insight into the mechanism by which long-term increases in plasma IGF-1 impart cognitive benefits in aged rats." So as you see this is not just a very promising peptide to research from a simple tissue building stand point, but also for research work about the brain/mind and possibly enhancing it in aged subjects.

So should you still use normal IGF-1 in your studies? If IGF-1 Des is an option to get, then NO!

IGF-1 Des is far superior to IGF1 and possibly even IGF1LR3 judging from current studies out there.

Get it right here >>> IGF DES 1mg

Refs:
1) Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 acti... [J Neurophysiol. 2005] - PubMed - NCBI
2) Sequence of cDNA encoding human insulin-like growth 2) factor I precursorM. Jansen*, F. M. A. van Shaikh?, A. T. Sicker??, B. Bullock??, D. E. Woods??, K. H. Gabby??, A. L. Nussbaum, J. S. Sussenbach & J. L. Van den Brande* Sequence of cDNA encoding human insulin-like growth factor I precursor
3) The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxia-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.Guan J, Williams CE, Skinner SJ, Mallard EC, Gluckman PD. The effects of insulin-like growth factor (IGF... [Endocrinology. 1996] - PubMed - NCBI
4) Differential effects of des IGF-1 on Erks, AKT-1 and P70 S6K activation in mouse skeletal and cardiac muscle.Li M, Li C, Parkhouse WS. Differential effects of des IGF-1 on Erks, ... [Mol Cell Biochem. 2002] - PubMed - NCBI

Ok so now Im confused. Im going to run a cjc1293/ghrp2 cycle and someone had mentioned/ suggested igf. I assumes igf 1 but now I see this- it sounds like this is much better. Input anyone ?