For this article I would like to talk about Raloxifene (Ralox) and its many possible research applications. Ralox is a Selective Estrogen Receptor Modulator (SERM) and to fully understand what Ralox is and can do you need to first understand the basics of what a "SERM" is.
A SERM is a compound that selectively binds to estrogen receptors in various parts of the body. When this happens it alters the effects of estrogen in some tissues, like for example breast tissue. SERMs are known to have been first researched for its possible application in the treatment of some cancers but that is not Ralox's only function. Ralox has shown to have many other possible research areas from fertility to Gynecomastia (Gyno) prevention and many more; it truly is a multi-faceted compound worthy of research.
Ralox has been shown in research studies to positively affect male research subjects with fertility related issues. Ralox does this by affecting the hypothalamic-pituitary-testicular axis (HPTA) and causing an increase of gonadotropin levels in the body. This was found to be crucial for an enhanced rate of conception in test subjects with infertility issues.
Ralox has also been found to have a very positive effect in research subjects with hormone related osteoporosis. Ralox shows these positive effects by increasing bone mineral density. Ralox was also found not to blunt growth hormone (GH) in both male and female test subjects, this matters because it has been shown to be an issue with some other SERM compounds currently being researched.
Ralox has proven very efficient in the prevention of Gyno in hormonally dysfunctional test subjects, but does not fix the underlying issues of hormonal dysfunction. Ralox in my opinion is still a good option as part of research into the treatment and/or prevention of gyno, possibly along with other compounds that may positively affect the underlying hormonal issues like an aromatase inhibitor. Ralox does not "fix" gyno but rather blocks estrogen from binding to the receptors in the breast glands and limits estrogens affects there, even with active hormonal dysfunction.
Ralox has been found to be very safe and effective in many research studies and well tolerated by test subjects. Ralox is a very promising compound and I feel further research is warranted into its many positive effects and possible applications.
It binds many times more strongly to the e receptor in breast tissue than any other avail serm offering the most effective gyno prevention/treatment. It also results in a 20% increase in testosterone production when not taking alongside anabolics that have induced shutdown. Its not talked about often enough IMO when it comes to gyno prevention or treatment. It is, IMO, the best option for that scenario.