nkira

For folks taking caffeine + epinephrine,

Some of the secondary effects of caffeine are probably caused by actions unrelated to adenosine. Caffeine is known to be a competitive inhibitor of the enzyme cAMP-phosphodiesterase (cAMP-PDE), which converts cyclic AMP (cAMP) in cells to its noncyclic form, thus allowing cAMP to build up in cells. Cyclic AMP participates in activation of protein kinase A (PKA) to begin the phosphorylation of specific enzymes used in glucose synthesis. By blocking its removal caffeine intensifies and prolongs the effects of epinephrine and epinephrine-like drugs such as amphetamine, methamphetamine, or methylphenidate. Increased concentrations of cAMP in parietal cells causes an increased activation of protein kinase A (PKA) which in turn increases activation of H+/K+ ATPase, resulting finally in increased gastric acid secretion by the cell. Cyclic AMP also increases the activity of the funny current, which directly increases heart rate.

Source - Same as above.

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jordybb

Well i think above 1200 mgm is too much of coffee, i take 1100 coffee daily and i am ok with it....

m11

Why is this?

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powerlifter316

Keep your coffee, however much you want as long as you aren't adding tons of cream and sugar. You don't need to worry about the stuff that has literally no calories when you're still trying to cut out bad foods and drinks.

Personally, I take a lot of caffeine before I train every day. Usually around 400-600 mg. This is in addition to some coffee or diet soda throughout the day. It gives me a good boost of energy, and I still sleep like a baby at night.

shell37

I thought this was interesting. I have ordered a kit and sent it off to a lab. Awaiting results.

Consumer Genetics: Caffeine Metabolism DNA Testing Services