Thread: Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

There are some strange comments in the study

1) Seven healthy men were studied for 5.5 h during euglycemic (5.5 mmol/l), hyperinsulinemic (430 pmol/l), fasting glucagon (65 ng/ 1),

what the hell did they feed them to make them hyperinsulinemic? Looks like AA's

2) In conclusion, plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis.

Hell yeah......AA 's buy themselves....turn to serum glucose at 58%, why we never eat protein alone

3)The mechanisms by which AAs could reduce skeletal muscle glucose uptake are as yet unclear. ......Moreover, endogenous release of insulin (18) and glucagon (19) induced by plasma AA elevation might have obscured possible direct effects of AAs in those studies. Taking together all these factors, it is uncertain whether AAs directly induce skeletal muscle insulin resistance in vivo and if so, which mechanism (glucose uptake versus substrate competition) is responsible for such an effect.

WTF......I hope my tax $$$ didn't pay for this


So...um w8.......what are you looking for?


DP

Originally posted by Dr. Pain
There are some strange comments in the study




So...um w8.......what are you looking for?


DP

A nice summary so I didn't have to read it all :ADD:

Just bolded something else....did I help?

DP