Thread: Serious question

This is a serious question so I am hoping to get some serious feedback. A friend of mine who I train with almost every day experienced some abnormal vaginal bleeding during her cardio session today. It was her first day off of her clen cycle and she was doing her regular 30 minute cardio session after weight training. She said that she felt light headed and then could feel that she began to bleed. When she went to check herself, she confirmed that she was bleeding. This is the first time this has ever happened to her. She Googled side effects of clen but nothing at all was mentioned about vaginal bleeding. Then she Googled physical exercise and vaginal bleeding and was yielded with a few results that basically said intense training could lead to vaginal bleeding. She has since stopped bleeding, but I figured I would get some insight from the females here. She is currently carb cycling with a refeed day. Some of her days she is almost entirely keto. The only supplements she uses is Fish Oil, Multi, Vitamin E, EFAs, BCAA's and occasionally Clen. Also, she has the Mirena birth control implanted in her just in case this is relevant at all. Thank you for your serious responses... it is much apprectiated.

I just had a quick peek through pubmed; it appears that beta-adrenergic stimulation has a profound effect on female sex organs, at least in pigs and calves. It appears to increase expression of progesterone and estrogen receptors in the reproductive tract of females. As an aside, this makes me nervous for estrogen sensitive cancers.

Genital Lesions following Long-term Administration of Clenbuterol in Female Pigs

Discussion
The results of this study show that long-term clenbuterol administration in finishing gilts causes lesions in the reproductive system, and induces an alteration of the cycling activity. Genital tract lesions following long-term clenbuterol administration have been reported in rats 2,22 and in cattle. Rats showed hydrometra and endometrial gland dilation associated with a significant increase in uterine estrogen receptor content.
The vagina and uterus of veal calves showed an abnormal collection of mucus, endometrial gland dilation, and microcystic ovaries associated with high concentrations of uterine estrogen and progesterone receptors.

Although the pathological changes in these species are different from those observed in the gilts in this experiment (i.e., small multiple follicular cysts, uterine and vaginal atrophy), it seems evident that the reproductive system is a target of clenbuterol action.

Down-regulation of beta-adrenergic receptors and u... [Am J Vet Res. 1995] - PubMed result

Abstract

Effects induced by long-term administration of clenbuterol at anabolic dosages (20 micrograms/kg of body weight for 40 days) on beta-adrenergic receptor (beta-AR) subtypes, estrogen receptors (ER), and progesterone receptors (PgR) in the reproductive system of female veal calves were investigated. Clenbuterol treatment induced a significant (P < 0.01) down-regulation of beta-AR subtypes (beta 1-AR, beta 2-AR, myometrial high-affinity beta 2-AR, and ovarian low-affinity beta 2-AR). On the other hand, a significant (P < 0.01) increase of uterine and ovarian ER and PgR receptors was observed in treated calves. Treatment did not affect dissociation constant values of beta-AR, ER, or PgR. In similar manner, clenbuterol did not significantly modify distribution of ER and PgR in the various tissues of the genital tract. In fact, these receptors were significantly (P < 0.05) more concentrated in the uterus than in the vagina in treated and untreated calves. Data indicated that prolonged clenbuterol exposure induced homologous beta-AR down-regulation (down-regulation of its specific receptors) and heterologous ER and PgR up-regulation (up-regulation of different types of receptors, not specifically bound by clenbuterol) in the genital tract of veal calves. Modification of the receptorial status could be reasonably related to the pathologic changes observed in long-term treated calves (eg, hydrometra, dilatation of uterine glands, cystic ovaries). The increased concentrations of ER and PgR suggested the possible existence of subcellular mechanisms regulated by repeated beta-adrenergic stimulation.