Trouble

Well, the reaction is natural, removing excess hormone, mostly estrogens, but its also been known to remove androgens *in specific tissues*, eg prostate, breast, uterine. NOT MUSCLE.

I sincerely doubt its removing your testosterone. As far as AKG goes, I would start with several small doses, 500 mg a day. See how you fare. Remembers, its excitatory in its action on gut. It may help your pancreas output for insulin.

Make sure you're not overcontrolling insulin release. I've done this in the past when I used both vanadium and chromium GTF at the same time. I've also done it when using too much K-ALA (too large of a daily dose). Result is a worsening of reactive hypoglycemia.

hardasnails1973

insulin is definiety a factor. I am keeping carbs the same as protein or just alittle lower. When ever I take in alot of carbs and lower protein I crash really hard and i have been this way pretty much all my life so that way a lower carb diet seem to work alot better then higher carbs in the past. I am using krala 100 mgs a day just as antioxident support. Been a few days since I leveled out nicely and strength and libido is coming back like before. I saw my dr at the gym and notified him of the changes I expreinced and he found that to be interesting. I will have more blood test in 2 weeks. Felt very strong tonight benched 315 for a few reps, but its a start. Blood test ought to be interesting to see the changes.

hardasnails1973

Trouble,
I just read your article your best post yet about "mineral imbalances and methylation" and reading that alot of light bulbs went on. The part about calcium/magnesium ratio 2:1 really hit home. Not this dr, but all the ND before was drilling magasium in to my body like it was going out of style I mean 1000 mgs or more a day for several months with even diagnostic testing and only Ca doing what was in my multivitamin may 600 mgs if that and I do not drink milk (allergic ). Does excess magnesium interfer with zinc absorption? Another point nicely made is that lack of methyl donors (me obviously) results in lower sam-e (we already estabilished that), but if excess of magnesium and b-6 leads to excess cysteine and taurine production. Now when you mention b-6 are referring also to the P5P form or just plan b-6 HCL). I wish other people would take time to read your articles from other boards because I am sure with the steroid use and enviromental toxins on the rise they are bound to run into problems with no medical explanations other then depression. You mentioned about using supplements of calcium and magnesium not insolation. Did you mean they must be taken together or as long as they are taken on a daily basis that will suffice. People at 350 mgs of magnesium start to experience symptomes of magnesium excess I found that totally interesting. I am sure if you posted something of that nature of here people would not even bother to read and appreciate basically possible life saving information was infront of them.

Trouble

No, zinc is regulated by iron and copper balance.

Mg+2 and Ca+2 are the common counterbalance ions in mito.

They have difference membrane channel transporters.

1000 mg of Mg is NOTHING. I recommend one or more grams a day for those who show signs of depletion, because they tend to favor calcium uptake due to acetate prevalence in gut.

If I take calcium, I have skin problems within a few days. Acetate is converted to glutamate and that sets off excess insulin release in me, which then causes subQ cells to release free fatty acids, which feed sebum production. Since these FFA can also worsen inflammation, this causes skin eruptions.

I tested the cascade many times. I can also elict the same response by eating an excess of grains in any given day (not bran, processed grains in bread or crackers).

Its a interesting feeback loop.

Excess B12 strips out methyl donors if its not methylated itself. Excess B6 will cause nightime disturbances in sleep. Excess magnesium cases muscle rigidity, they feel very hard, and breathing can feel as though you have a band around your chest. The other sign is gastric upset.

Unless you have clear signs of Ca deficiency in blood tests, I wouldn't take excess calcium. Ask you ND.You get in food as well. Unless you show signs of osteoporosis, I would be cautious about using calcium. 600 mg is a standard supplement dose for adults.

The whole point of using supplemental magnesium is to address GI muscosal cell Mg+2 uptake errors due to competition from Ca. You don't just absorb the ions because they are there. Its regulated.

hardasnails1973

That is very interesting points. Now we all know we need testosterone for muscle building but that has to be balanced with estrogen, but i tried to find out what the consequences of lowering estrogen too low in terms of muscle buiilding and anabolic properties, but found little data. All these body builders taking anti estrogens could they actually being doing more harm then good because. I looked back on all mylab test and when I had my testosterone in the 900-1000 range, my progesterone was elevated and my estrodial was on the low end. I found that very strange. But what are the side effects of driving estrogen too low for a male. i could not find alot but symptoms of excess and low are almost identical. This will all be cleared up next week when I get my blood work done. What i found interesting is that estrogen raises copper serum levels and it also can raise cortisol levels thats could i could benefit from that greatly. i did find one study of male aromatase deficeincy but it did not explain things too clearly. The picture of the showed muscle atrophy and big pot belly.

hardasnails1973

Could hypomethylation cause a defect in the metallothionein process which regulates zinc /copper metabolism. I am beginning to understand the "methy trape" would methylcobalin, and samme TMG help to overide this.
I have been taking about 50 - 100 mgs of p5p in a subligual for a long time could this be causing CBS pathway to be overactivated reducing the methioine synthase pathway. I also found a great article that testosterone in controlled dosages helps to reverse NASH.

hardasnails1973

I found this to completely explain what is going on in my methylation imbalance.

It is hypothesised that B12 deficiency may reduce both extracellular choline supplies and intraneuronal synthesis and thereby result in the characteristic cholinergic deficit of AD.

As discussed previously, one effect of B12 deficiency is impairment of essential methylation reactions, due to reduced formation of SAM, and important source of intracellular methyl-groups . Nitrous oxide induced cobalamin inactivation in the rat results in lowered levels of hepatic SAM and methylation reactions are compromised . These animals remain well, however, and it has been shown that an alternative B12 independent pathway for methylation of homocysteine to methionine is induced . This is the betaine homocysteine methyltransferase pathway, betaine supplying the methyl group instead of methyl-folate. Betaine is derived from the oxidation of choline via betaine aldehyde. Hence, B12 deficiency results in the diversion of endogenous and dietary choline to overcome the MS block, with consequent reduction in plasma and extraneuronal supplies.

It is also proposed that intraneuronal choline synthesis is compromised in B12 deficiency. Choline may be released from phosphatidylcholine (PC) by base exchange of phospho-lipase mediated hydrolyses . PC is formed either by the incorporation of existing choline, or by de novo synthesis. The latter process involves three sequential methylations of PC by SAM . B12 deficiency should therefore result in a decreased supply of neuronal SAM. Furthermore, betaine homocysteine methyltransferase is absent in the brain , which will further exacerbate this process. Sequential methylation of PE to PC will therefore be inhibited in B12 deficiency, resulting in impaired de novo synthesis of intraneuronal choline. There will also be an inversion of the SAM/SAH ratio, thereby inhibiting all transmethylation reactions .


http://www.alzforum.org/res/adh/cur/...laminergic.asp

Is Folinic acid the same thing as 5- methyltetrahydrofolate?

hardasnails1973

bump

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