
BBC NEWS | Health | Obesity 'controlled by the brain'
Seven new gene variants discovered by scientists suggest strongly that obesity is largely a mind problem.
The findings suggest the brain plays the dominant role in controlling appetite, and that obesity cannot easily be blamed on metabolic flaws.
Two international studies, published in Nature Genetics, examined samples from thousands of people for the tiniest genetic changes.
Many of the seven key variants seem to be active in the brain.
This suggests that the brain's impact on appetite and eating behaviour may be more important that any genetic variation which alters the body's ability to lay down or burn up fat.
All seven variants were picked up by a study led by Icelandic company deCODE Genetics, while six of the seven were also identified in a second, independent study by an international team dubbed the Giant consortium.
In both cases the researchers scrutinised DNA samples from thousands of people to assess the impact of tiny changes.
Each of the variants identified had a small impact on obesity, but a person carrying all of them was typically around 1.5kg - 2kg heavier than average.
It is estimated that as much as 70% of the variation in body mass index - a measure of obesity based on height and weight - is down to genetics, rather than environmental factors.
Researcher Dr Kari Stefansson, of deCODE Genetics said: "This suggests that as we work to develop better means of combating obesity, we need to focus on the regulation of appetite at least as much as on the metabolic factors of how the body uses and stores energy."
Major step forward
Dr Alan Guttmacher, of the US National Human Genome Research Institute, said the research was a major step forward in understanding how the human body regulates weight.
However, Professor Peter Weissberg, of the at the British Heart Foundation, expressed caution.
He said: "This research adds to the growing body of evidence that some people are more at risk of becoming obese because of their genes.
"It suggests that some people may be less able than others to resist the temptation to overeat because of their genetic background and it might start to explain why some people have no problem keeping their weight down whilst others struggle.
"However, this cannot be the explanation for the current epidemic of obesity since these genes have been present for centuries and the obesity epidemic is a relatively new phenomenon."
Almost one in four people in the UK is now classified as obese, and expert predict the proportion will continue to rise sharply.
"you thought it was over, its not over, I came back, I brought my axe!!!!
Journal
Listen you stupid pieces of shit, your trailer park up bringing is showing!


And a former fatty. I struggled with my weight for almost twenty years, and it was not fun. I jogged 10k 3x a week for almost ten years trying to keep it down to a dull roar. It didn't help.
I wasn't fat because I was a glutton. I was fat because on the standard dietary guidelines offered up to overweight women (ie low fat, low protein) my appetite outpaced my energy requirements. It took me a while, but I managed to figure out a way to eat and train that didn't make me hungry all the time. Once I had that part, I dropped the weight, got off type II diabetes meds and got my life back.
I don't think too many people are walking around out there who like being obese. Having tried everything under the sun before I finally stumbled upon the way to keep my weight off, let me tell you, it sure as shit ain't easy to figure out what to do.
Barbs is already losing weight and comes here for support. She doesn't need to read sewage like what's been posted here. Nobody does.
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Thank you KelJu. I appreciate that.
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I'm sure there are some people out there with a legitimate reason to be overweight, but the vast majority of overweight people do two things: 1, They eat like it's going out of style; 2, they blame it on a medical problem that has never been diagnosed.
For fat people it always comes down to someone or something else's fault. Those that that take it upon themselves to take control are the one's that lose weight. Sure, you may have been given a bad diet, but ultimately, you chose to education yourself and take control.
For most people though, it means putting down the fork.


You got anything upon which to base your assertion, DOMS?
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Just anecdotal. I've seen many, many fat people over the years that complained about being overweight, yet ate fast food for lunch...and a lot of it.
It also seems glaringly obvious that obesity if a much greater problem in first-world countries than third-world countries. Because we have a greater access to food and not to an over abundance of bad dietitians.


Interestingly, obesity is a far greater problem the farther away one gets from urban centres.
When I was growing up, most people weren't fat. There was maybe one fat kid in the school, and she had a "gland problem".
You don't blame dieticians? Hmmm...
I don't blame them individually, but I do blame how they are trained. Low-fat has to be THE worst idea that ever got foisted upon us - it has been a DISASTER. It gave people the false notion that as long as what they eat is "low in fat" they can eat unlimited quantities of it. I was one of these poor fools, and I was hungry all the time.
And have YOU tried to construct a diet based on the guidelines offered up by the American Food Pyramid, or the Canada Food Guide? We all know how to eat, right? We're well-entrenched in physical culture, we know that it's calories in, calories out, that we can't realistically expect to control our weight in either direction through exercise, and that the calorie is king, right?
Figure everybody knows this?
Got any idea why the ADA still recommends a low-fat, high complex carbohydrate diet to type II diabetics?
While you're at it, got any idea why low-carbohydrate diets aren't routinely recommended to people with high cholesterol? The AHA's step I diet has been clinically shown to worsen your lipid profile. Bad cholesterol drops, a little, but good cholesterol drops a little MORE. And the point drop is trivial at best. Compare this with what typically happens on Atkins, where good cholesterol actually RISES while total cholesterol and triglycerides drop. Remember, Atkins was a cardiologist. My doctor put me on Atkins to fix my lipid profile and it worked. Good doctor - I was lucky. Most would have just put me on Statins when I was 33, jogging 10k 3x a week and overweight with high cholesterol on my former low-fat diet. I would have been told "it's just your genetics".
My genetics predisposed me to overwhelming hunger if I tried to follow a low-fat, high-carb diet. There was nothing in my genetics that prevented me from maintaining a healthy bodyweight on reasonable calories - but I didn't even know what that meant until I got onto the bodybuilding boards.
Think hard about how few really know this.
No wonder people just give up. I almost did.
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Not only what Built said, but the people that are supposed to be "educating" us on health issues are often clueless themselves. Both my high school PE teacher and our health teacher were both extremely overweight (go figure).
It's not that I chose to be fat, I fucking hated it. I was just never educated on how to eat or understand nutrition. I had no concept of how bad something like soda really was for you up until I started reading these boards in my freshman year of college. I was always told that I just needed to get outside more and/or do cardio which we all know is blatantly wrong.
Ron Paul 2012
No gym for home, work out floor with 30, but is it for 20 like 30 lb when you no lift it to be for men, for 30 lbs instead? or half is 10 for 20 pounds?

I don't know how old you are, but I'm guessing that you went to school pre-1980. The eighties saw the rise, and abuse of, cheap easy to get food known as fast food. But this is irrelevant...
I didn't say that dietitians weren't to blame, just that individual diets choices are a far more greater problem.
So...the reason that the kids in your school weren't fat was that the FDA had it right back then? The logic to that argument just isn't there.


I don't know what to tell you - but they sure as shit don't have it right NOW.
And I'm forty five.
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My sister is 31 years old. She hardly ever eats fast food, candy, junk food. She does on the other hand, eat lots of carbs. Spaghetti, pizza about once a week, bread. She is very overweight. She is finally realizing that it is the carbs and not the lack of exercise and fatty foods. As we know everyone is different. I could eat my sisters diet and probably lose weight.


Not if you ate more calories than you require.
It's not the carbs that are making her fat - the carbs are making her HUNGRY, so she overeats. She is currently living my former nightmare.
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