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Well, the nice thing is that, sort of by definition, the successful bodybuilders and such don't have as much of a problem with stubborn fat (I like the term invincible) as the rest of us. It's semi-circular reasoning mind you but it still holds. Basically, if they are successful, they don't have problems with it; if they had problems with it, they wouldn't be successful. But yes, trying to get rid of taht last little stubborn fat (which just does NOT want to be mobilized for all kinds of annoying reasons) can lead to more muscle loss. Your body has to fulfill the caloric deficit from somewhere; if you can't mobilize fatty acids to do it, the calories will come from muscle. But that's all kind of tangential, the question is what, if anything can be done about it. The first question is why it's so stubborn and there are many different reasons. Part of it has to do with the receptor types on the fat cells (alpha-2 vs. beta-1,2). Stubborn fat has more alpha-2 receptors which send anti-fat mobilizing signals. There is also a blood flow issue, stubborn fat has poor blood flow. So it's hard to get fat mobilizing hormones in or the fatty acids out. Unfortunately, the research can't seem to decide what's causing the blood flow problems exactly: that is what all is regulating it (it's a combination of alpha and beta adrenoreceptor but nobody seems to be sure which are involved exactly, nitric oxide plays a role, so does angiotensin, so do prostaglandins, there may be other factors). There are other reasons too, but not as important. Without going into the brutally long and complicated mental machinations that led me to this (and I'm still working on the overall scheme, but you can be a guinea pig), here's my current thoughts on how to approach it. First and foremost, this is one of the places where morning/pre-breakfast cardio is probably crucially important. An hour or two before cardio, take 200 mg caffeine (vivarin) with 1-3 grams of L-tyrosine (NO ephedrine). there are two segments to the cardio. The first segment is for mobilization, to get those stubborn fatty acids out of the fat cell. The second segment is the oxidation part, to burn them off in the muscle. For the first segment of the cardio, use a machine that you don't normally use. So if you normally do the treadmill, do the first segment on the stairmaster or bike or something. Just make it different. First segment: warmup: 3-5 minutes go hard: 5-10 minutes. I mean hard, as hard as you can stand for the entire time. This will NOT be fun on lowered blood glucose. I've considered putting intervals here but haven't found the data I need to make up my mind. If you do intervals, go somethign like 5X1' all out wiht 1' break (10' total intervals) Rest 5', just sit on your butt, drink water, try not to puke. Go to your normal cardio machine. Do at least 30 minutes at moderate/high moderate intensity (below lactate threshold but decent intensity). I'd say 45' maximum here but I'm still making up my mind and looking at data. Go home, an hour later, have a small protein meal (25-50 grams or so). No dietary fat. 2-3 hours later, go back to normal diet eating. Your daily calories shouldn't be any different than they were already, they are just distributed differently, you only have 100-200 after cardio, and then the rest afterwards. I'd do that maybe 3 days per week to start. Quick reasons: These two are the same answer: To get stubborn fat mobilized, you have to overcome fairly severe resistance in terms of both blood flow and lipolysis, this requires very high concentrations of catecholamines (adrenaline/noradrenaline). Sadly, jacking up levels of catecholamines (necessary for mobilization) limits burning in the muscle which is why you follow the high intensity with low intensity. Basically, you jack up levels to get the fat mobilized, and then let them fall so that the fatty acid can be burned in the muscle. I ahve a study showing that E before intense activity lowers the catecholamine response, that's the reason for avoiding it. Studies also show a lower than normla catecholamine response as people adapt to a given type of cardio; doing a different machine will result in a higher catecholamine response than you'd other wise get. |
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Originally posted by w8lifter Very interesting! Incidentally, that's how I do my cardio....balls to the wall the first ten minutes...however, I almost always use the same machine, and I almost always use ephedrine...I didn't know it lowered the catecolamine response. btw...it's "intriguing"
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Originally posted by w8lifter and I almost always use ephedrine...I didn't know it lowered the catecolamine response. |
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Clin Sci (Lond) 1999 May;96(5):483-91 Related Articles, Books, LinkOut Acute effect of ephedrine on 24-h energy balance. Shannon JR, Gottesdiener K, Jordan J, Chen K, Flattery S, Larson PJ, Candelore MR, Gertz B, Robertson D, Sun M. Autonomic Dysfunction Center, AA3228 MCN, Vanderbilt University, Nashville, TN 37232-2195, USA. Ephedrine is used to help achieve weight control. Data on its true efficacy and mechanisms in altering energy balance in human subjects are limited. We aimed to determine the acute effect of ephedrine on 24-h energy expenditure, mechanical work and urinary catecholamines in a double-blind, randomized, placebo-controlled, two-period crossover study. Ten healthy volunteers were given ephedrine (50 mg) or placebo thrice daily during each of two 24-h periods (ephedrine and placebo) in a whole-room indirect calorimeter, which accurately measures minute-by-minute energy expenditure and mechanical work. Measurements were taken of 24-h energy expenditure, mechanical work, urinary catecholamines and binding of (+/-)ephedrine in vitro to human beta1-, beta2- and beta3-adrenoreceptors. Twenty-four-hour energy expenditure was 3.6% greater (8965+/-1301 versus 8648+/-1347 kJ, P<0.05) with ephedrine than with placebo, but mechanical work was not different between the ephedrine and placebo periods. Noradrenaline excretion was lower with ephedrine (0.032+/-0.011 microg/mg creatinine) compared with placebo (0.044+/-0.012 microg/mg creatinine) (P<0.05). (+/-)Ephedrine is a relatively weak partial agonist of human beta1- and beta2-adrenoreceptors, and had no detectable activity at human beta3-adrenoreceptors. Ephedrine (50 mg thrice daily) modestly increases energy expenditure in normal human subjects. A lack of binding of ephedrine to beta3-adrenoreceptors and the observed decrease in urinary noradrenaline during ephedrine treatment suggest that the thermogenic effect of ephedrine results from direct beta1-/beta2-adrenoreceptor agonism. An indirect beta3-adrenergic effect through the release of noradrenaline seems unlikely as urinary noradrenaline decreased significantly with ephedrine. Publication Types: Clinical Trial Randomized Controlled Trial PMID: 10209080 [PubMed - indexed for MEDLINE] |
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Med Sci Sports Exerc 2002 Feb;34(2):344-9 Related Articles, Books, LinkOut Effect of ingesting caffeine and ephedrine on 10-km run performance. Bell DG, McLellan TM, Sabiston CM. Defence and Civil Institute of Environmental Medicine, Toronto, Ontario, Canada. doug.bell@dciem.dnd.ca . BACKGROUND: The ingestion of either caffeine (C) or ephedrine (E) has been shown to improve performance during high-intensity aerobic activity lasting 10-20 min, with an additive effect being found when the combination (C + E) was ingested. It was the purpose of this study to determine if the addition of E to C would improve performance in activity lasting longer than 20 min. METHODS: One and one half hours after ingesting a placebo (P), C (4 mg/kg), E (0.8 mg/kg), or C + E, 12 subjects performed a 10-km run while wearing a helmet and backpack weighing 11 kg. The trials were performed in a climatic suite at 12-13 degrees C, on a treadmill where the speed was regulated by the subject. VO(2), VCO(2), V(E), heart rate (HR), and rating of perceived exertion (RPE) were measured during the run at 15 and 30 min, and again when the individual reached 9 km. Blood was sampled at 15 and 30 min and again at the end of the run and assayed for lactate, glucose, and catecholamines. RESULTS: Run times (mean +/- SD), in minutes, were for C (46.0 +/- 2.8), E (45.5 +/- 2.9), C + E (45.7 +/- 3.3), and P (46.8 +/- 3.2). The run times for the E trials (E and C + E) were significantly reduced compared with the non-E trials (C and P). Pace was increased for the E trials compared with the non-E trials over the last 5 km of the run. VO(2) was not affected by drug ingestion. HR was elevated for the ephedrine trials (E and C + E). RPE remained similar for all trails. Caffeine increased the epinephrine and norepinephrine response associated with exercise and also increased blood lactate, glucose, and glycerol levels. Ephedrine reduced the epinephrine response but increased dopamine and FFA levels. CONCLUSION: The previously seen additive nature of E and C was not evident in this study, with the primary ergogenic effect being attributed to E. Publication Types: Clinical Trial Controlled Clinical Trial PMID: 11828246 [PubMed - indexed for MEDLINE] |
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Originally posted by davatar When I do that I get lightheaded from all the blood flowing away from my brain, at which point I usually say to myself "I feel like crap today" and wimp out. Perhaps a regular warmup 10-15 minutes and then intervals, followed by endurance until you've done about 60 minutes? |
| An hour or two before cardio, take 200 mg caffeine (vivarin) with 1-3 grams of L-tyrosine (NO ephedrine). |
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