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Insulin resistance and anabolism

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Posted by: Revenant

I'm told insulin resistance results in the pancreas releasing more insulin. Does this extra insulin give an added anabolic effect or does insulin resistance mean that the anabolic effects of insulin are diminished?

BTW, I'm starting to think I have an insulin resistance. How can I find out for sure? I've noticed that after consuming a lot of carbs, particularly simple sugars, I slip into a tranquilised state of mind sometimes with an accompanying physical fatigue.


Posted by: gopro

Your cells are resisitant to the effects of insulin therefore the body secretes more in an effort to make up for it. This is not a good thing. However, an extremely large percentage of the population has a degree of IR. I wouldn't be too worried about it in terms of muscle building.


Posted by: The_Chicken_Daddy

Quote:
Originally posted by Revenant
BTW, I'm starting to think I have an insulin resistance. How can I find out for sure? I've noticed that after consuming a lot of carbs, particularly simple sugars, I slip into a tranquilised state of mind sometimes with an accompanying physical fatigue.

That's cause of tryptophan, not IR.


Posted by: The_Chicken_Daddy

Well, seritonnin more specifically, but tryptophan is the precursor.


Posted by: Nigeepoo

How does eating carbs result in high tryptophan?


Posted by: The_Chicken_Daddy

There are about 5 amino acids that compete for transport over the blood brain barrier. Tryptophan is bound to albumen, so it's too big to bind to insulin. When you eat carbs and there is an insulin release from the pancreas, it can take some of the remaining four aminos away into cells, leaving the tryptophan quite an easy path over the BBB and into the brain where it quite nicely converts into seritonnin.

If you eat protein with your carbs, you tend to keep the blood amino profile high enough to prevent this, but sharp rises in insulin, from simple sugars or if you eat too much carbs in one sitting, can still cause problems of lethargy and tiredness.


Posted by: Rob_NC

Hmmm,,,, Interesting stuff. Now I understand why my wife can't get anything done after lunch. Seriously, I have to remind her constantly to up her protein intake.


Posted by: P-funk

Quote:
There are about 5 amino acids that compete for transport over the blood brain barrier. Tryptophan is bound to albumen, so it's too big to bind to insulin. When you eat carbs and there is an insulin release from the pancreas, it can take some of the remaining four aminos away into cells, leaving the tryptophan quite an easy path over the BBB and into the brain where it quite nicely converts into seritonnin.
Damn, beat me to it.

This also explains why when people are deppressed they eat junk foods. Becasue the high amounts of sugar release tryptophan and the seratonin makes you feel so damn good. And thus begins the cycle of carb addiction .


Posted by: Nigeepoo

Ah!

I thought serotonin was a neurotransmitter and high levels acted as a stimulant.

I had a 5 hour OGTT during January and 75g of glucose nearly sent me off to sleep. Luckily, although I have impaired glucose control, I'm nowhere near diabetic.


Posted by: The_Chicken_Daddy

You may be aware of the post-lunchtime daze that most office workers seem to suffer - i believe it's also the time where work is least productive?

Well, now you know the cause.







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