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Alcohol and Testosterone


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Posted by: LAM

people are always asking how consuming alcohol effects testosterone levels. here is an example.

Alcohol effects on luteinizing hormone and testosterone in male macaque monkeys

NK Mello, JH Mendelson, MP Bree, J Ellingboe and AS Skupny

The effects of alcohol (2.5 and 3.5 g/kg) on luteinizing hormone (LH) and testosterone were studied in adult male macaque monkeys under both basal and naloxone-stimulated conditions. Integrated plasma samples were collected at 30-min intervals for 90 min before nasogastric intubation of alcohol (2.5 and 3.5 g/kg) or a sucrose control solution, isocalorically equivalent to 2.5 g/kg of alcohol. Under basal (non- naloxone-stimulated) conditions, alcohol (2.5 or 3.5 g/kg) did not change LH levels significantly from prealcohol control levels. When basal testosterone levels were normal (600-1300 ng/dl), alcohol significantly suppressed testosterone levels in a dose-dependent manner. Testosterone levels decreased by 52% (P less than .05) within 30 min after a 3.5 g/kg dose of alcohol. As average blood alcohol levels increased to 400 mg/dl and above, testosterone levels fell monotonically and remained over 70% below base-line levels (P less than .01). After administration of 2.5 g/kg alcohol, testosterone levels were significantly suppressed within 90 min (P less than .05) and remained 52 to 63% below control levels (P less than .02-.05) as average blood alcohol levels increased to 300 mg/dl. However, when basal testosterone levels were abnormally low (100-200 ng/dl), alcohol had no effect on testosterone or LH. Naloxone stimulation was used to circumvent the high incidence of abnormally low testosterone levels observed. Naloxone (0.5 mg/kg i.v.) administration 90 min after alcohol (2.5 and 3.5 g/kg) or sucrose control administration significantly increased LH levels in comparison to base line (P less than .02-.001). LH reached peak values within 60 min after naloxone administration. A significant increase in testosterone (P less than .001) was observed 90 min after naloxone administration as LH levels began to decline. Alcohol (2.5 and 3.5 g/kg) did not attenuate or delay naloxone- stimulated increases in LH and testosterone in comparison to sucrose control conditions.

Volume 233, Issue 3, pp. 588-596, 06/01/1985
Copyright © 1985 by American Society for Pharmacology and Experimental Therapeutics


Posted by: guyfromkop

that study is 20 years old


Posted by: LAM

Quote:
Originally Posted by guyfromkop
that study is 20 years old
and that would matter why ? I guess the human genome has changed since then..


Posted by: TJ Cline

Quote:
Originally Posted by guyfromkop
that study is 20 years old

The studies on atomic bombs are over 60 years old so the must not work anymore

Lam, sum up the study in la-mans terms......also I have read that alchol and testosterone ( as in steroid cycles) will increase estrogen and the chances for gyno go up ?


Posted by: HardTrainer

Quote:
Originally Posted by LAM
and that would matter why ? I guess the human genome has changed since then..
Lam there is no way that study is usable in todays world, 20 years on you have the likes of ronnie coleman compared to arnold, you have creatine and prohormones now the advances in supplement technology is better then 20 years ago, how the hell can that study hold water now?

p.s. did i make a good argument... did i???? i hope i did


Posted by: LAM

here are the main points:

When basal testosterone levels were normal (600-1300 ng/dl), alcohol significantly suppressed testosterone levels in a dose-dependent manner.

this says that when baseline total testosterone levels were in the normal range of 600-1300 ng/dl that alochol suppresses test levels in a dose dependat manner. basically the more you drink the more test is suppressed.

Testosterone levels decreased by 52% (P less than .05) within 30 min after a 3.5 g/kg dose of alcohol. As average blood alcohol levels increased to 400 mg/dl and above, testosterone levels fell monotonically and remained over 70% below base-line levels (P less than .01).

when a 3.5g/kg dose of alchol was consuming causing BAC levels of 400 mg/dl or greater test levels fell by 70% as compaired to baseline test levels.

After administration of 2.5 g/kg alcohol, testosterone levels were significantly suppressed within 90 min (P less than .05) and remained 52 to 63% below control levels (P less than .02-.05) as average blood alcohol levels increased to 300 mg/dl.

when a 2.5g/kg dose of alchol was consuming causing BAC levels of 300 mg/dl or greater test levels fell by 52-63% as compaired to baseline test levels.

re-inforcing the fact that test suppression via alchol consumption is dose dependant. the higher your BAC the great the suppression of testosterone


However, when basal testosterone levels were abnormally low (100-200 ng/dl), alcohol had no effect on testosterone or LH.

when baseline test levels are under the normal range the consumption of alcohol does not cause suppression or effect luteinizing hormone (LH). so if you have low test levels to begin with the consumption of alchol does not supress testosterone levels


Posted by: LAM

Quote:
Originally Posted by HardTrainer
Lam there is no way that study is usable in todays world, 20 years on you have the likes of ronnie coleman compared to arnold, you have creatine and prohormones now the advances in supplement technology is better then 20 years ago, how the hell can that study hold water now?

p.s. did i make a good argument... did i???? i hope i did
lol ! I would like to see some MRI's and DEXA scans and ultrasound scans of Ronnies body. imagine what in the hell is going on in there ! can't be good...



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