Second-messenger [Forum Archive]

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Second-messenger

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Posted by: TJ Cline

Can someone explain to me, Second-messeneger mechanisms of amino-acid based hormones.
I just cant grasp it.

Posted by: musclepump

Hormone (first messenger) binds to its receptor, which then binds to a G protein
The G protein is then activated as it binds GTP, displacing GDP
Activated G protein activates the effector enzyme adenylate cyclase
Adenylate cyclase generates cAMP (second messenger ) from ATP
cAMP activates protein kinases, which then cause cellular effects

Posted by: Jodi

I could help, I suppose but if I recall you said I had issues..........Hmmm........

Actually you are better off reading this. I know a little bit on the subject but not enough to feel confidant I'd be giving you all proper info. http://web.indstate.edu/thcme/mwking...-hormones.html

Posted by: TJ Cline

Quote:

Originally Posted by musclepump

Hormone (first messenger) binds to its receptor, which then binds to a G protein
The G protein is then activated as it binds GTP, displacing GDP
Activated G protein activates the effector enzyme adenylate cyclase
Adenylate cyclase generates cAMP (second messenger ) from ATP
cAMP activates protein kinases, which then cause cellular effects

thanks MP, with the chart and your info I think I have it now

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Second-messenger

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