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Originally Posted by Purdue Power
If you don't have to worry about estrogen-related problems(ie. gyno), then there is no reason to take Nolva or an aromitase inhibitor during your cycle. You need to have estrogen in your system to have an optimal anabolic environment(evidence against aromitase inhibitors). Nolva inhibits IGF-1 production, thus lowering your gains.
On the other hand, if you have estrogen-related problems, then you will need to take one or the other to limit or eliminate those problems while on cycle. Always have them on hand in case you need them, but you won't know for sure if you are going to need them until you are actually on-cycle. |
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Estrogen suppression in males: metabolic effects. Mauras N, O'Brien KO, Klein KO, Hayes V. Nemours Research Programs at the Nemours Children's Clinic, Jacksonville, Florida 32207, USA. nmauras@nemours.org We have shown that testosterone (T) deficiency per se is associated with marked catabolic effects on protein, calcium metabolism, and body composition in men independent of changes in GH or insulin-like growth factor I production. It is not clear,,however, whether estrogens have a major role in whole body anabolism in males. We investigated the metabolic effects of selective estrogen suppression in the male using a potent aromatase inhibitor, arimidex (Anastrozole). First, a dose-response study of 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses; hence, a 1-mg dose was selected for other studies. Subsequently, eight males (aged 15-22 yr; four adults and four late pubertal) had isotopic infusions of [(13)C]leucine and (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray absorptiometry, isokinetic dynamometry, and growth factors measurements performed before and after 10 weeks of daily doses of arimidex. Contrary to the effects of T withdrawal, there were no significant changes in body composition (body mass index, fat mass, and fat-free mass) after estrogen suppression or in rates of protein synthesis or degradation; carbohydrate, lipid, or protein oxidation; muscle strength; calcium kinetics; or bone growth factors concentrations. However, E2 concentrations decreased 48% (P = 0.006), with no significant change in mean and peak GH concentrations, but with an 18% decrease in plasma insulin-like growth factor I concentrations. There was a 58% increase in serum T (P = 0.0001), sex hormone-binding globulin did not change, whereas LH and FSH concentrations increased (P < 0.02, both). Serum bone markers, osteocalcin and bone alkaline phosphatase concentrations, and rates of bone calcium deposition and resorption did not change. In conclusion, these data suggest that in the male 1) estrogens do not contribute significantly to the changes in body composition and protein synthesis observed with changing androgen levels; 2) estrogen is a main regulator of the gonadal-pituitary feedback for the gonadotropin axis; and 3) this level of aromatase inhibition does not negatively impact either kinetically measured rates of bone calcium turnover or indirect markers of bone calcium turnover, at least in the short term. Further studies will provide valuable information on whether timed aromatase inhibition can be useful in increasing the height potential of pubertal boys with profound growth retardation without the confounding negative effects of gonadal androgen suppression. Publication Types: Clinical Trial PMID: 10902781 [PubMed - indexed for MEDLINE] |
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Originally Posted by musclepump
Here's a question... is ANY itching worth using Nolva for? Or should it be persistent before busting out the AIs?
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Originally Posted by stax
is taking nolvladex your entire cycle good, bad, or great?
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Originally Posted by Getbig82
How much Arimidex do you take throughout the cycle Toughman?
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Originally Posted by Getbig82
Sucks for me I can get gyno at times.What HCG do you recommend(Tough). I was told that actually Proviron was best with Test. which is a rare case of its use, instead of arimidex. I think Proviron is harder to get though. It's better because, it attaches to a certain molecule in Test. and allows more free testosterone,which promotes gains.(Am I correct)?
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Originally Posted by Mudge
Nothing attaches to testosterone, AI (aromatase inhibitors) prevent some of the testosterone from converting to estrogen by inhibiting aromatase conversion rates.
People either love proviron, or say its highly overrated. |
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Originally Posted by Tough Old Man
And your personal opinion on Proviron? Over rated or not. I say over rated
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