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High doses of nandrolone decanoate reduce volume of testis and length of seminiferous


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Posted by: Pirate!

High doses of nandrolone decanoate reduce volume of testis and length of seminiferous tubules in rats.

Noorafshan A, Karbalay-Doust S, Ardekani FM.

Shiraz University of Medical Sciences, Shiraz, Iran. noora@sums.ac.ir

Anabolic-androgenic steroid (AAS) compounds rank among the drugs most widely abused with the goal of improving athletic ability, appearance, or muscle mass. It has been shown that these compounds have adverse effects on human and animal physiology and sperm quality, but quantitative structural changes of the testis have received less attention. The present study was conducted to evaluate the effects of nandrolone decanoate, which is one of the AAS compounds, on testis weight and volume, diameter and length of seminiferous tubules in rats by unbiased stereological methods. Adult rats were divided into three groups. The first comprised control rats; the second and third groups received low and high doses of nandrolone decanoate for 14 weeks. The rats were then left untreated for 14 weeks. After removal of the testis, stereological study of these tissues showed that the mean volume of testis and length of the seminiferous tubules in the animals that received high doses of nandrolone decanoate were reduced approximately 32% (p<0.01) and approximately 31% (p<0.04), respectively, in comparison with the control group. It can be concluded that the high doses of nandrolone decanoate produce structural changes in the rat testis that remain 14 weeks after stopping injection of the drug.


Posted by: musclepump

Poor rats didn't get a drop of Nolva


Posted by: Tough Old Man

Lets see. Right now I'm doing 1 gram of test, 600 eq and 450 deca. 2050 mgs total. Think i'll bump the deca up to 600


Posted by: Tha Don

Quote:
Originally Posted by musclepump
Poor rats didn't get a drop of Nolva
lol, how would that help them?

so what implications would this have, less chance of being fertile?


Posted by: Pirate!

Quote:
Originally Posted by Tha Don
less chance of being fertile?
Yes, decreased sperm production. The tubules are usually ~2 ft long.


Posted by: Tha Don

wow, so a reduction of 32% just from one deca cycle, another good reason why i'm never touching deca!


Posted by: redflash

Quote:
Originally Posted by Tha Don
wow, so a reduction of 32% just from one deca cycle, another good reason why i'm never touching deca!
I see nothing here that says other AAS would be better or worse... if they did a control study at all then it was with non-AAS not other-AAS. If you are minded to avoid Deca, you should avoid all AAS based on what is presented here. I don't think Deca has a special tubule-shortening chemical structure or anything else which would not be found in other AAS, perhaps more so. Based on the evidence presented...

Flash


Posted by: Pirate!

Very true. It isn't just nandrolone that sends the nuts on vacation. If you shut down the HPTA, you not only shut down LH but FSH, as well.


Posted by: Tha Don

on vacation? meaning the tubes should regrow when you come off?


Posted by: Pirate!

They can regrow in time.


Posted by: Tha Don

ah, in that case pass the deca!


Posted by: luke69duke69

The tubes you're talking about is that the ones your nads hang from? So they make your nuts hang not as far down?


Posted by: Pirate!

Quote:
Originally Posted by luke69duke69
The tubes you're talking about is that the ones your nads hang from? So they make your nuts hang not as far down?
They are actually in your nuts.
Look at this diagram


Posted by: luke69duke69

Oh ok. I was kinda confused.



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