Originally Posted by Trouble

Not sure that this rationale works. Yes, you dilute the anabolics load delivered to pretty dense tissue (intramuscular) but the injection oil (drug delivery vehicle) is far from being innocent in terms of inducing inflammation.

I've mentioned this before; in fact, my eyebrows shot to my hairline when I first heard about using grapeseed oil.

Its loaded, and I mean loaded, with omega-6 fatty acids that can and do get converted to arachidonic acid and its metabolites, known to actively promote inflammation.

The difference in reaction to these injections is then a combination of induvidual sensitivity to inflammation response (eg. local concentration of omega-3s that counter the omega-6 inflammatory action), bolus concentration (anabolic agent tendency to invoke pain and inflammation, a function of loading rate: total mgs/vol injected) and injection density; muscle status and previous history of injections to the site, and injection technique. I propose a little discussion here to see if we can identify factors that can be wiggled (adjusted) to reduce injection pain.

Probably might be a good idea to look over this list of factors, see if I missed anything, prioritize them, and then look for alternative options.

Anybody who has ever given or received an injection knows that technique can be important; adjuvant is a big, big issue. Rate of injection of viscous adjuvent is yet another.

I'm also wondering if a topical application that blocks or reduces pain perception an hour or more ahead of the injection might not be a bad idea.

And Mudge mentions the most obvious item: sterility of the injection. Your idea of sterilization and mine (from the technique I've seen described) are two different versions of reality.

Originally Posted by Trouble

Its an awkward site for injection. You use these muscles for locomotion; this can make you more aware of injection site irritation. Maybe you have a skinny ass and it overloads the muscles, who knows.