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6-OXO IS PROVEN TO BE SAFE, EFFECTIVE AT RAISING TESTOSTERONE AND LOWERING AROMATASE ACTIVITY.

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Dan Rohle1 , Colin Wilborn2 , Lem Taylor3 , Chris Mulligan4 , Richard Kreider5 and Darryn Willoughby5,6

1 Pharmacology Department, Weill Cornell Graduate School of Medical Sciences, 445 East 69th Street, Room 412, New York, NY 10021, USA
2 Department of Exercise and Sport Science, University of Mary Hardin-Baylor, UMHB Station, 900 College Box 8010, Belton, Texas 76513, USA
3 Department of Health, Leisure, and Exercise Science, University of West Florida, 11000 University Parkway, # 72-219, Pensacola, FL 32514, USA
4 Department of Nutrition and Food Science, Colorado State University, Fort Collins, CO 80523, USA
5 Department of Health, Human Performance, and Recreation, Baylor University, Box 97313, Waco, TX 76798, USA
6 Institute for Biomedical Studies, Baylor University, Waco, TX 76798, USA

Journal of the International Society of Sports Nutrition 2007, 4:13doi:10.1186/1550-2783-4-13
The electronic version of this article is the complete one and can be found online at: Journal of the International Society of Sports Nutrition | Full text | Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resis
Received:25 September 2007Accepted:19 October 2007Published:19 October 2007
© 2007 Rohle et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (Creative Commons — Attribution 2.0 Generic — CC BY 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to determine the effects of 6-OXO, a purported nutritional aromatase inhibitor, in a dose dependent manner on body composition, serum hormone levels, and clinical safety markers in resistance trained males. Sixteen males were supplemented with either 300 mg or 600 mg of 6-OXO in a double-blind manner for eight weeks. Blood and urine samples were obtained at weeks 0, 1, 3, 8, and 11 (after a 3-week washout period). Blood samples were analyzed for total testosterone (TT), free testosterone (FT), dihydrotestosterone (DHT), estradiol, estriol, estrone, SHBG, leutinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH), cortisol, FT/estradiol (T/E). Blood and urine were also analyzed for clinical chemistry markers. Data were analyzed with two-way MANOVA. For all of the serum hormones, there were no significant differences between groups (p > 0.05). Compared to baseline, free testosterone underwent overall increases of 90% for 300 mg 6-OXO and 84% for 600 mg, respectively (p < 0.05). DHT underwent significant overall increases (p < 0.05) of 192% and 265% with 300 mg and 600 mg, respectively. T/E increased 53% and 67% for 300 mg and 600 mg 6-OXO, respectively. For estrone, 300 mg produced an overall increase of 22%, whereas 600 mg caused a 52% increase (p < 0.05). Body composition did not change with supplementation (p > 0.05) and clinical safety markers were not adversely affected with ingestion of either supplement dose (p > 0.05).
While neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.

The science of IronMagLabs E-Control Rx with 6-OXO

It's The Scientific Results That Go Beyond the high Expectations of Every Serious Bodybuilder ...

When advanced bodybuilders think of IronMagLabs, they think of state-of-the-art prohormones--like the revolutionary product Super-DMZ Rx. Most recently, IronMagLabs developed E-control Rx with 6-OXO[TM] -- a unique compound that has been shown in scientific literature to be a "suicide" inhibitor of the estrogen producing enzyme aromatase. In addition, it was believed that 6-OXO would also increase testosterone levels through manipulation of the body's natural hormonal feedback system. This was great news for bodybuilders who desired in-cycle and post-cycle estrogen management as well as a boost in testosterone.

However, research has revealed that the power of 6-OXO is even greater than had been anticipated, and therefore has even more to offer the competitive or serious bodybuilder. With the advent of 6-OXO, ErgoPharm founder, Patrick Arnold, has once again delivered a compound to the sport that is destined to become a staple in every bodybuilder's arsenal. In fact, no matter what level of development you've attained, it just might be the most effective supplement for maximizing your anabolic environment. IronMagLabs recognizes the power of 6-OXO and has made it the main ingredient of E-Control Rx.

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Science Serious Bodybuilders Can Use

A study on 6-OXO was completed by a prestigious clinical research organization. This study examined the blood hormone responses over a 3-week cycle of 600mg per day of 6-OXO. The study used 6 normal men aged 32-40, and in addition to tracking changes in sex hormone levels it also looked at common indicators of toxicity.

The results were very impressive. Total testosterone levels rose an average of 188%, while free testosterone levels rose an average of 226% over the course of the three weeks! The variability among the 6 subjects was quite low, and majority of the testosterone increase was acheived after only the first week. Not only that, but there was NO indication of acute toxicity and in some areas (cholesterol, liver function) health and function even improved!! Results from two of the six subjects are demonstrated below:


An Advanced Look At The Estrogen/Testosterone Connection

A decrease in estradiol (the bioactive form of estrogen) was seen, but unlike testosterone the change was not drastic--levels still remained within the low end of normal. The explanation for this is simple; 6-OXO acts to inhibit the aromatase enzyme and block the conversion of testosterone to estradiol. A consequence of this is a signal from the brain to increase production of testosterone to compensate for the blocked estradiol production. As testosterone levels increase, so do estradiol levels since more substrate has now become available for the aromatase enzyme. Basically, what has occurred is the establishment of a new baseline level of testosterone to maintain the body's normal levels of estradiol. This sort of hormonal response is in fact very desirable, as decreasing estradiol levels below normal can be detrimental. E-control rx with 6-OXO will CONTROL estrogen but not CRUSH it.


The Clinically Proven Supplement For Serious Results

Finally, E-control rx with 6-OXO is the only product that is both an effective estrogen inhibitor AND a non-hormonal testosterone trigger. It's the product with the science every serious bodybuilder has been waiting for.

* What: E-Control Rx with 6-OXO contains a natural compound that helps trigger the release of Luteinizing Hormone (LH). Recent data by a prestigious clinical research organization has shown that after 3 weeks of 600mg/day, test subjects averaged a 226% increase in free testosterone! 6-OXO also combats estrogen formation by inhibiting aromatase.

* Why: Having increased testosterone is a no-brainer--train harder and recover faster. But estrogen contributes to a host of unwanted side effects--water retention, gyno (bitch tits), moodiness, and an overall smooth, soft look.

* Who: Any athlete interested in achieving a hard, lean physique. E-control with 6-OXO is for those that have been predictably disappointed by the hype promised by cheap Tribulus and other non-hormonal testosterone boosters.

IronMagLabs E-Control Rx

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