Thread: Cla

zebraez@hotmail. welcome to IM!

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Welcome to IM!

Originally Posted by zebraez@hotmail.

Hi, I'm a new member to this site. I'm interested in knowing more about CLA. I live on a fixed income so I have to be careful how I spend my money. I'm trying to get the best value, quality, etc for the little that I can afford on supplements. I have lost over 30 lbs but I need to loose "fat". Question: Can I just purchase safflower oil instead of CLA supplements and what would be the benefits/difference of each? Any help is greatly apreciated. Thanks.

Conjugated linoleic acid (CLA) and obesity.

Silveira MB, Carraro R, Monereo S, Tébar J.
Servicio de Endocrinología y Nutrición, Hospital Universitario de La Princesa, Diego de León, 62. 28006 Madrid, Spain. belensilveira@telefonica.net

Abstract

BACKGROUND: The term conjugated linoleic acid (CLA) refers to several positional and geometric conjugated dienoic isomers of linoleic acid (LA), of which the trans-10,cis-12 isomer has been reported to reduce adiposity and increase lean mass in mice and other animals when included at <or=1% of the diet. However, most dietary CLA in humans is obtained from dairy products, accounting for the cis-9,trans-11 CLA isomer, also known as rumenic acid, for more than 90% of the total CLA intake. Commercial CLA preparations industrially produced, containing trans-10,cis-12 and cis-9,trans-11 CLA isomers in diverse proportions, are attracting consumers' interest because of the purported body fat-lowering effects of CLA, coupled to the perception of a 'natural' compound devoid of harmful effects. Nevertheless, despite numerous studies on CLA effects on body composition for nearly a decade, the mechanisms by which CLA isomers elicit their effects remain largely unknown. The purpose of this paper is to provide an updated review of the studies performed on animals and humans, as well as to describe the potential mechanisms involved in CLA effects on body weight and composition and metabolism.

METHOD: Literature review.

RESULTS: Experiments in humans have not been able to show a significant effect on body weight, body composition or weight regain related to either of the CLA isomers. In fact, some studies suggest a tendency towards a decrease in body fat mass and an increase in body lean mass, while some others raise concern about the possibility of deleterious effects of trans-10,cis-12 CLA on lipid profile, glucose metabolism and insulin sensitivity.

CONCLUSIONS: Evidence regarding effectiveness of CLA in humans is not concluding.