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#1 |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Pergolide, Mirapex, Amphetamine, Selegeline, and other assorted halloween candies
I'm gonna run this log here at IM and also at Lyle's board. I like the input from people here and there... unfortunately everyone posts at different boards.
![]() I'm still "bulking," although diet has been less than stellar. Weights are going up still, but im up to 240lbs as of this morning. I look a lot better than the last time i saw this weight, but im still fat. Just been too busy to really put a concerted effort into eating cleanly. Anyway, here's the log:------ This is mostly going to be a log of my generally uneducated experimentation upon myself with drugs im familiar with only from the unchecked and often dangerously ignorant depths of the internet. Oh yeah, a few books, too. For an overview of myself: I'm psychiatrically impaired. When unmedicated, ive got some wickedly severe depression/suicidal ideation, severe ADD, mild OCD, and a host of related psychodevelopmental problems as a result (which i wont delve into, since we only just got rid of a Kevin, and probably dont need another). Thus far it seems most of my problems are related to dopamine (duh). Wellbutrin, adderall, and mirapex (a potent non-ergot D3 agonist with moderate D2/D4 activity) have all had profound impacts on my situation. It's interesting to note that i have a lot of "thrill seeking" behavior - which has often been attributed to an attempt at "self medication." i.e. low basal levels of DA promote a compulsion to increase levels through excitement. I find this to be very true, as i speed far too often, and lost my license for a month because i had accumulated too many speeding tickets (that was after getting out of a shit-ton of them in court/through favors, too). I also skydive, scuba dive relatively recklessly, and generally try to stimulate myself. It's interesting that in all of these situations, i find myself at my calmest and most serene. i.e. the first time i jumped out of a plane. I was kneeling at the doorway, nervous as shit, but as soon as i left the plane - it was the most serene, incredibly relaxed, most meditative experience of my life. I had never felt so utterly peaceful. Paradoxical, no? Anyway, of the three, the mirapex has been the most impressive. It's something i'd like to write about in more detail, but just dont have the time. There are a lot of people ive seen around these various forums (especially some of the lunatics at avant) who have symptoms that seem to parallel my own, and who i think could benefit greatly from mirapex. Psychiatrically, it's my wonder drug. Anyway, something else to add to my "list of things to do during winter break." For what im currently taking: 60mg racemic amphetamine/adderall XR 1x AM 30mg racemic amphetamine/adderall (instant release) as needed, i.e. when the XR stops working 150mg venlafaxine/effexor 1x AM 300mg bupropion/wellbutrin 1x AM 500mcg pramipexole/mirapex 2x AM/PM (has a relatively short half life, dosed upon waking and 8 hours later, but not after 6pm... although timing really isnt as important as something like pergolide) The current supplements arent much... fish oil, whey, calcium, vit c, multivit/min, b complex. Sesathin occassionally. I should be taking NAC, but measuring out the powder 2x a day was a pain in the ass, so i stopped. Im waiting on fucking 1fast to ship my order, in which i finally bought a capper. Anyway, what prompted this journal was a decision to toy around with pergolide. Ive been trying to find some a non-ergot D1 agonist, but it just doesnt exist. Theres not even anything close to in-vivo human clinical trials around, yet... so that really leaves me with no choice. What really piqued my interest in the D1 receptor is its relative abundance in the prefrontal cortex relative to other areas of the brain, and the prefrontal cortex/dopamine theory of depression/add/ocd/etc. Im figuring that something like a selective D1/D2 agonist would have very few side effects in someone like myself, since DA activity in these regions would be very minimal to begin with. And as for body comp effects, there should be relatively drastic optimizations, since the system has been out of whack to begin with - this wouldnt simply be putting higher octane gas in the engine, as one might parallel pergolide use in an otherwise healthy individual. This should be the equivelent of trading in that busted up civic with the unpainted wing for a V10 viper. My hopes, at least. So, that brings us to today. I threw back 125mcg of pergolide this morning. I was going to start at 250mcg, as i assumed my tolerance should be relatively high given the lack of side effects i had when titrating up with mirapex (and the fact that i was on mirapex to begin with), but i cant chance being unproductive today, so played it safe. Tdose+1:45 and i havent experienced a single side. I should note that the only drug i discontinued was the mirapex (although depending on how things go, i may reintroduce it). The only worry i have is the cardiac damage related with pergolide use. It seems like it only happens in people using high dose, long term pergolide... but i honestly havent looked into it very thoroughly. It's something that would have been prudent to do before i started the drug, but hey, who needs a heart anyway? Off to the gym, now. |
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#2 |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Training is still a take on Lyle's version of periodization. It's supposed to be a 3 day split - chest/back/grip, quads/hams/calves, shoulders/bi/tri/abs. However, lately its only been a 2 day split, with no direct shoulder/bi/tri/ab work. This is mostly because i often find myself running out of time in the day to get to the gym, which constantly screws up my split. The direct work on that day really isnt necessary, though, so im not worried. Those muscles have been getting plenty of direct work on the other days.
So, we have todays w/o: Chest/Back Flat BB press - 3/0/x tempo, 4-5 min RI 235lbx2 235lbx2 235lbx2 BB row - 3/0/1 tempo, 2-3 min RI 205lbx6 205lbx6 205lbx6 205lbx5 205lbx5 205lbx4 Flat BB press - 3/0/2 tempo, 1-2 min RI 155lbx8 155lbx8 155lbx6 155lbx6 WG pulldowns - 3/0/2 tempo, 1-2 min RI 140lbx13 140lbx9 --- Decent. Prolly gonna some stuff around (emphasis, rep range, and whatnot) in a few weeks. I dont really like having flat BB press as my only chest movement. Strength has progressed, though, for sure. |
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#3 |
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Peak Physiques™
Join Date: Mar 2002
Location: NY
Posts: 7,870
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Damn, you are fucked up. And I mean that in the nicest way possible.
![]() Seriously though, perg messed me up bad, and I saw no body comp effects. |
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#4 |
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Peak Physiques™
Join Date: Mar 2002
Location: NY
Posts: 7,870
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Oh, and I don't have any of those issues, but right before jumping, and while freefalling was probably the most serene experience of my life as well.
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#5 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
Weird about the pergolide... how high a dose did you maintain and for how long? Could ya describe "messed me up bad" any better? And why the fuck doesnt ANYTHING work on you? I wonder if a gunshot would. |
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#6 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
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#7 |
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Nor*Cal
Elite Member
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Gonna stick with updating this journal with school and all? lol jk Good luck with this one.Re: The only worry i have is the cardiac damage related with pergolide use. It seems like it only happens in people using high dose, long term pergolide... but i honestly havent looked into it very thoroughly. It's something that would have been prudent to do before i started the drug, but hey, who needs a heart anyway (Maybe I should ask my dad for ya. He's a cardiologist).When did you first sky dive? I want to do that. |
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#8 |
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Peak Physiques™
Join Date: Mar 2002
Location: NY
Posts: 7,870
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125 knocked me on my ass. Nauseous, sick, worn down, sleepy, major flu-like symptoms. Nasty.
Then I worked all the way up to 1800 or so. If nothing else, I can persevere. And nothing. |
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#9 |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Yeah, im turning into a bit of a MonStar... lol. I don't see any reason i won't stick with this log, seeing as how ive basically described it as covering nearly everything in my life. Time will tell, though.
![]() I did that skydive like 2.5 years ago in australia. Did it right over the coast. We were actually a good 500 feet off shore for the jump, and just glided in to the beach. It's definitely worth doing. IIRC, lessons werent too expensive... but going tandem is just as fun. Steve, thats fuckin bizarre that you had all the sides and none of the benefits. Did the sides lessen at all while you stabilized at 1800? I forgot to post this earlier, but i popped 500mcg of mirapex around 4pm this afternoon, as it seemed as if the pergs initial effects (regarding mood, etc) were wearing off. I was expecting at least some mild nausea, consider i now had two D2 agonists in my system... but there was nothing. Felt fine. I'm gonna head on up to 250mcg tomorrow, if that still doesnt hit me, im goin straight for 500. I'm still thinkin i should be able to titrate up pretty damn quickly. The only thing that might slow me down is coinciding dose increases with days my schedule is relatively light... so if the DA hits the fan, i wont be totally screwed. |
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#10 |
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Peak Physiques™
Join Date: Mar 2002
Location: NY
Posts: 7,870
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I titrated very slowly (125 every few days). Sides stabilized, but were always prevelant. Coming off was one of the best feelings of my life.
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#11 |
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Mom/Student/Wifey
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Wow, thanks for sharing all of that. I too have suffered from severe depression but the thrill seeking is something I try to stay away from b/c I used to have panic attacks. What exaxtly is Peroglide?
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Current weight 130.4
Goal weight 125 11 bf% Overall Goal is to be the best I can be and feel good ![]() http://www.ironmagazineforums.com/ga...ent_BF-med.jpg |
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#12 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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#13 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
Check the other issues of M&M for the rest of the series. ![]() |
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#14 | |
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Mom/Student/Wifey
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Quote:
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Current weight 130.4
Goal weight 125 11 bf% Overall Goal is to be the best I can be and feel good ![]() http://www.ironmagazineforums.com/ga...ent_BF-med.jpg |
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#15 |
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Registered User
Join Date: Apr 2004
Posts: 395
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all power to you for trying to find the answers yourself albeit thru drugs not karma. when was the last time you experienced drug-free 'reality' in all its horror and brutality? can you remember feeling depressed in as a child?
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#16 |
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Patrick
Super Moderator
Join Date: Dec 2002
Location: AZ
Posts: 30,631
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Hey Mon. Cool joural. Any specifc physique goals in mind? Or just bulking up as much as possible? Why did you decide to do your rep ranges to a cadance?
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http://pwtraining.blogspot.com/.....come and see what is on my mind!
Ivonne's Blog on Health and Wellness! Looking for online training/coaching/consulting? --> Optimum Sports Performance "In the beginners mind there are many possibilities, in the experts there are few." -Buddha's Little Instruction Book |
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#17 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
Have you tried other types of appetite suppressants for your binging? What about therapy? |
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#18 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
![]() I dont mind talking about my immediate psychological problems, but the psychosocial/psychodevelopmental stuff isnt something im too comfortable with (even though i realize its all related). But yeah, i can remember a lot of this stuff relating to me as a kid (pre puberty). Even as far back as preschool... which is bizarre, since my memory in general is awful. I barely remember anything before i was 10-12... and the stuff i do remember only seems to stick out in my mind as being fairly traumatic. lol. Such is life. ![]() |
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#19 | |
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Mom/Student/Wifey
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Quote:
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Current weight 130.4
Goal weight 125 11 bf% Overall Goal is to be the best I can be and feel good ![]() http://www.ironmagazineforums.com/ga...ent_BF-med.jpg |
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#20 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
![]() But honestly, the whole idea of this past bulk was that it was going to be clean and short. I wanted to get back to cutting, since i felt i was still pretty fat (and i was). I'm probably back up around 18% BF at this point. Thats just a guess, though, since ive learned to hate that little 3-point electronic accucheck thing. Pants are a tad tighter, but i really dont look that much larger... probably because im so tall. Shit, back when i was 300lbs, i didnt even look that fat. ![]() Anyway, my schedule has been completely screwy lately, so my diet has been junk. Junk leads to junk, of course... so my self-control is lacking as well. I went out last night to a performance of "Beethoven's 3's" by the local symphony orchestra, and during the intermission, passed over the turkey sandwiches for a cookie. Not to mention what my meal looked like before the show (16oz of filet mignon, flambe'd to perfection amid peppercorn and cognac). ![]() Over the past week i gained 2lbs, which is actually amazingly good considering how much crap ive been eating... probably around the 5-6kcal/day mark. Of the 20lbs i gained, id say 8-10 is water, too... since a lot of that weight came in the first week when i stopped starving myself and ate brown rice like it was my job. Goals for now are really nonexistent. As i see it now, i'm gonna just wing it untill winter break, and then probably begin cutting again. As for the rep ranges... what do you mean exactly? You talking about the tempo? Or the actual variation in rep ranges? |
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#21 | |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Quote:
I don't want to come off as offensive and be like "PERGOLIDE IS WAY TOO HARDCORE FOR YOU," i just that think it'd be overkill for you, and probably out of the realm of what effects youre looking for. Especially considering how friggin awesome you look in those pics. ![]() But as an appetite suppressent... i think you were the one who started that thread asking about them in the supplement forum, right? All the ones people suggested in there would certainly help. I think nicotine gum would be especially helpful for you during those sudden cravings. I've never used it, but TP said Anorect-In worked great, too... and id definitely trust his recommendations. |
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#22 |
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OMGWTFBBQ
Join Date: Feb 2003
Location: MA
Posts: 4,002
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Journal update:
Bumped to 250mcg of pergolide this morning. T+1:00 i'm getting a bit of nausea, very similar to what i experienced when titrating up on the mirapex. Could it be that nausea is a side effect of D2 activity only...? This could make things very, very interesting if an orally active D1-specific agonist becomes available.... |
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#23 | |
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Patrick
Super Moderator
Join Date: Dec 2002
Location: AZ
Posts: 30,631
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Quote:
yeah, the tempo cadance. |
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http://pwtraining.blogspot.com/.....come and see what is on my mind!
Ivonne's Blog on Health and Wellness! Looking for online training/coaching/consulting? --> Optimum Sports Performance "In the beginners mind there are many possibilities, in the experts there are few." -Buddha's Little Instruction Book |
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#24 | |
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Registered User
Join Date: Apr 2004
Posts: 395
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Quote:
do you have any specific diet plans or just to eat clean as poss? you seemed pretty disciplined in the past. |
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#25 |
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OMGWTFBBQ
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