Its a dumb idea. Gamers have been changing the configuration of their keyboard layout for long time though custom configuration built into the game. Anyway, with a game, you forget what the key says, and learn where the key is building hand eye coordination with the keys. The ctrl button stops being ctrl, and becomes jump in your mind.
As far as applications go, who actually has problems doing what they want with a $19.00 keyboard. If you are having problems with photoshop, its you, not the keyboard or application.