Thread: Aromasin frequency

ED or EOD. Once a day or more, it doesn't really matter. I hope that helps.

Try taking it with some ANPB as the fat helps the chemical absorb better.

Exemestane reaches steady blood plasma levels of after a week of administration and this is also when we see it begin its maximal effect on reducing circulating estrogen levels. It’s also has a ½ life of 27 hours (4), so taking it once per day is going to build up blood plasma levels to a very effective level.
12.5 EOD is what I use .. I think you still have to adjust to your needs dose and freq. If 2x a day works for u do it

How would one know if they are using too much Exemestane?

joint dryness and overall facial dryness could be one indicator

Originally Posted by cutright

Exemestane reaches steady blood plasma levels of after a week of administration and this is also when we see it begin its maximal effect on reducing circulating estrogen levels. It’s also has a ½ life of 27 hours (4), so taking it once per day is going to build up blood plasma levels to a very effective level.
12.5 EOD is what I use .. I think you still have to adjust to your needs dose and freq. If 2x a day works for u do it

Your source for the half life was measuring females. The half life in males is WAY shorter because of our higher T levels. Twice daily dosing is ideal for maximal E2 suppression. Once daily will work though.

Originally Posted by colorado

How would one know if they are using too much Exemestane?

Bloodwork

Originally Posted by heavyiron

Your source for the half life was measuring females. The half life in males is WAY shorter because of our higher T levels. Twice daily dosing is ideal for maximal E2 suppression. Once daily will work though.

Your right sorry about that I should have posted that with that article... It's hard to find study's on male subjects most of all I find are for females

Originally Posted by cutright

Your right sorry about that I should have posted that with that article... It's hard to find study's on male subjects most of all I find are for females

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe
Nemours Children’s Clinic and Research Programs (N.M., J.L., A.R.), Jacksonville, Florida 32207; and University of Florida Health Sciences Center (D.P.) and Amersham Pharmacia Biotech (E.d.S., A.K., B.L.), Peapack, New Jersey 07977

Address all correspondence and requests for reprints to: Nelly Mauras, M.D., Nemours Children’s Clinic, 807 Children’s Way, Jacksonville, Florida 32207. E-mail: nmauras@nemours.org.

Abstract

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

Awesome thanks!^^^^^

Originally Posted by cutright

Awesome thanks!^^^^^

No problem

Only 14%? Wow I thought it was much higher.

Did I read that wrong?

Originally Posted by SloppyJ

Only 14%? Wow I thought it was much higher.

Did I read that wrong?

62% plus or minus 14%. Its an average of sorts.

That's 62 plus or minus 14, so 48-76 %

Thanks for clearing that up!

Originally Posted by heavyiron

Your source for the half life was measuring females. The half life in males is WAY shorter because of our higher T levels. Twice daily dosing is ideal for maximal E2 suppression. Once daily will work though.

So do you take 12.5 mg every day, heavyiron?

Originally Posted by heavyiron

Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males

Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe
Nemours Children’s Clinic and Research Programs (N.M., J.L., A.R.), Jacksonville, Florida 32207; and University of Florida Health Sciences Center (D.P.) and Amersham Pharmacia Biotech (E.d.S., A.K., B.L.), Peapack, New Jersey 07977

Address all correspondence and requests for reprints to: Nelly Mauras, M.D., Nemours Children’s Clinic, 807 Children’s Way, Jacksonville, Florida 32207. E-mail: nmauras@nemours.org.

Abstract

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

Good stuff...thanks for that.

12.5mg ed works like a charm

Ive been taking 12.5 eod of Sciroxx Aromasin and it been working great

Originally Posted by keith1569

12.5mg ed works like a charm

same here, best ai there is, easily

personally EOD does not work for me..my nips start to get sore and sensitive if i dont dose every day

I may go to every 3rd day, but then I am on simple 600 mg test weekly.

I need some of that shit! I trust, thus far EP, but they been all soled out of Exemestane. BOGUS!

Be sure to stock up next time its in!!! A few bottles lasts a long time.

I just did, and appreciate the advice!

By chance, what is the shelf life for aromasin or nova? Can you freeze it, is it necessary.

No matter the dose ED!! Not EOD!!!

Originally Posted by Bigb21084

I just did, and appreciate the advice!

By chance, what is the shelf life for aromasin or nova? Can you freeze it, is it necessary.

I was told 2 years by research stop, if you keep it in a dark cool place.

Originally Posted by atlas114

No matter the dose ED!! Not EOD!!!

Why?