Thread: OMG Follistatin rocks

Is this mixed with BW as well? What are the sides? And at what point on the gear should this be used ( what week) for best results if wanting to use for a 10 day period?

Originally Posted by SomeGuy

Recent logs have shown gains of a little more then 1 pound per day in small 7 to 10 day cycles.

Very interesting & exciting.

Review links please?

What logs? I have never found one.

Originally Posted by Thresh

What logs? I have never found one.

Google search "follistatin log" = 15,500 results (0.06 seconds)

that was so hard

Originally Posted by TwisT

Google search "follistatin log" = 15,500 results (0.06 seconds)

that was so hard

That google search turns out 15,000 useless results. Farthest log I could find was 3 days in. I'm not signing up for the forum on the first search result, so that's useless. The 2nd log is bunk, doesn't list any days, and is only an advertisement for EP (nothing wrong with that but it screams advertisement and not independent log, especially when your sig is advertising were to buy it) = not reputable.

The rest just seems to be info and questions about the product. I'm not bashing anyone or any company (I use EP), but the first post had huge claims with zero references. Then points out what the logs show. I still have yet to find a reputable log. If you know any by all means just post the link, not useless google search results.

Not much data on it yet.. i will let rest of the rats jump on it first

Originally Posted by minimal

Not much data on it yet.. i will let rest of the rats jump on it first

Exactly why I'm asking for a neutral log.

Originally Posted by TwisT

Google search "follistatin log" = 15,500 results (0.06 seconds)

that was so hard

Nonsense, none of those logs are for EP and a number of the ones Ive read the test subjects became ill shortly after beginning administration. If you guys are offering a better quality product then I need proof.

No disrespect T, but who in their right mind is going to pay $180+ for a 10 day supply of compound without seeing some feedback? You mentioned in another thread there were some logs, why do you link them for us?

there's is feed back out there and its good. if you look hard enough you will find it. if i had it like that rite now i would be all over this peptide.there is about 4 companies that i know of that are selling it and getting great feed back and ep is one of them and there all selling it for about the same price

Have yet to try it but it is def on my horizon! I have been VERY pleased with EPs IGF DES and PEG MGF so far. It is NUTS!

Originally Posted by Hench

Nonsense, none of those logs are for EP and a number of the ones Ive read the test subjects became ill shortly after beginning administration. If you guys are offering a better quality product then I need proof.

No disrespect T, but who in their right mind is going to pay $180+ for a 10 day supply of compound without seeing some feedback? You mentioned in another thread there were some logs, why do you link them for us?

That was a different follistatin with a different tag from a different company. Theres loads of feedback on follistatin, including logs and clinical studies. read the original post about the 10 day progress. I cant give links to other forums, against the rules.

Originally Posted by tjsulli

there's is feed back out there and its good. if you look hard enough you will find it. if i had it like that rite now i would be all over this peptide.there is about 4 companies that i know of that are selling it and getting great feed back and ep is one of them and there all selling it for about the same price

I'm glad i'm not the only one who knows how to search (other) forums

Originally Posted by OutWhey

Have yet to try it but it is def on my horizon! I have been VERY pleased with EPs IGF DES and PEG MGF so far. It is NUTS!

Originally Posted by Thresh

Exactly why I'm asking for a neutral log.

Why dont you go look on pro muscle???????????????????????????????????????????? ??? the first result in the google search, and there are MULTIPLE logs. Idk how much more I can hold your hand through this lol

Originally Posted by minimal

Not much data on it yet.. i will let rest of the rats jump on it first

theres enormous ammounts of data?


Well here, fuck.

Abstract

Follistatin (FS) inhibits several members of the TGF-beta superfamily, including myostatin (Mstn), a negative regulator of muscle growth. Mstn inhibition by FS represents a potential therapeutic approach of muscle atrophy. The aim of our study was to investigate the mechanisms of the FS-induced muscle hypertrophy. To test the role of satellite cells in the FS effect, we used irradiation to destroy their proliferative capacity. FS overexpression increased the muscle weight by about 37% in control animals, but the increase reached only 20% in irradiated muscle, supporting the role of cell proliferation in the FS-induced hypertrophy. Surprisingly, the muscle hypertrophy caused by FS reached the same magnitude in Mstn-KO as in WT mice, suggesting that Mstn might not be the only ligand of FS involved in the regulation of muscle mass. To assess the role of activin (Act), another FS ligand, in the FS-induced hypertrophy, we electroporated FSI-I, a FS mutant that does not bind Act with high affinity. Whereas FS electroporation increased muscle weight by 32%, the muscle weight gain induced by FSI-I reached only 14%. Furthermore, in Mstn-KO mice, FSI-I overexpression failed to induce hypertrophy, in contrast to FS. Therefore, these results suggest that Act inhibition may contribute to FS-induced hypertrophy. Finally, the role of Act as a regulator of muscle mass was supported by the observation that ActA overexpression induced muscle weight loss (-15%). In conclusion, our results show that satellite cell proliferation and both Mstn and Act inhibition are involved in the FS-induced muscle hypertrophy.


Abstract

Antagonists of myostatin, a blood-borne negative regulator of muscle growth produced in muscle cells, have shown considerable promise for enhancing muscle mass and strength in rodent studies and could serve as potential therapeutic agents for human muscle diseases. One of the most potent of these agents, follistatin, is both safe and effective in mice, but similar tests have not been performed in nonhuman primates. To assess this important criterion for clinical translation, we tested an alternatively spliced form of human follistatin that affects skeletal muscle but that has only minimal effects on nonmuscle cells. When injected into the quadriceps of cynomolgus macaque monkeys, a follistatin isoform expressed from an adeno-associated virus serotype 1 vector, AAV1-FS344, induced pronounced and durable increases in muscle size and strength. Long-term expression of the transgene did not produce any abnormal changes in the morphology or function of key organs, indicating the safety of gene delivery by intramuscular injection of an AAV1 vector. Our results, together with the findings in mice, suggest that therapy with AAV1-FS344 may improve muscle mass and function in patients with certain degenerative muscle disorders.


Abstract

In most cases, pharmacologic strategies to treat genetic muscle disorders and certain acquired disorders, such as sporadic inclusion body myositis, have produced modest clinical benefits. In these conditions, inhibition of the myostatin pathway represents an alternative strategy to improve functional outcomes. Preclinical data that support this approach clearly demonstrate the potential for blocking the myostatin pathway. Follistatin has emerged as a powerful antagonist of myostatin that can increase muscle mass and strength. Follistatin was first isolated from the ovary and is known to suppress follicle-stimulating hormone. This raises concerns for potential adverse effects on the hypothalamic-pituitary-gonadal axis and possible reproductive capabilities. In this review we demonstrate a strategy to bypass off-target effects using an alternatively spliced cDNA of follistatin (FS344) delivered by adeno-associated virus (AAV) to muscle. The transgene product is a peptide of 315 amino acids that is secreted from the muscle and circulates in the serum, thus avoiding cell-surface binding sites. Using this approach our translational studies show increased muscle size and strength in species ranging from mice to monkeys. Adverse effects are avoided, and no organ system pathology or change in reproductive capabilities has been seen. These findings provide the impetus to move toward gene therapy clinical trials with delivery of AAV-FS344 to increase size and function of muscle in patients with neuromuscular disease.





Abstract

In addition to gene correction therapy and cell transplantation techniques, multidisciplinary approaches to drug discovery and development offer promising therapeutic strategies for intractable genetic muscular disorders including muscular dystrophy. Inhibition of the production and activity of myostatin, a potent growth factor that determines skeletal muscle size, is a novel strategy for the treatment of muscle-wasting disorders such as muscular dystrophy, cachexia and sarcopenia. Myostatin blockers include myostatin-blocking antibodies, myostatin propeptide, follistatin and follistatin-related proteins, soluble myostatin receptors, small interfering RNA and small chemical inhibitors. This review describes the discovery and development of myostatin inhibitors.




Ill stop there. And whoever asked for references on the first post then you PM me if you really want them. I know who wrote that article, but he couldnt post it himself because of human use. Understand?



You people put me in the worst mood sometimes...




go bruins

-T

Twist, I thought those studies were with the virus attached, making it gene therapy?

not trying to put you in a bad mood T, almost all the logs I found were more or less asking questions, or telling everyone they are going to start it, I just could not find logs that were completed.

Thank you for posting more info though.

Originally Posted by Thresh

Twist, I thought those studies were with the virus attached, making it gene therapy?

not trying to put you in a bad mood T, almost all the logs I found were more or less asking questions, or telling everyone they are going to start it, I just could not find logs that were completed.

Thank you for posting more info though.

Correct, they were knockout mice. Obviously, we dont have the ability to sell the virus, nor could it be used for anything but research on mice. The thing we can do is supply the gene or amino that the virus is responsible for replicating and producing, in this case FS 344 or follistatin 344, which is practically the same thing to research with, yet giving us more control on the amounts we want to research, and having more control over the FS. There are I think two or three that completed a 10 day research log, in the peptides section.

-T

Yeah but the mice were retarded.

Originally Posted by Glycomann

Yeah but the mice were retarded.

Hahaha follistatin 344 is some serious stuff

Originally Posted by TwisT

Correct, they were knockout mice. Obviously, we dont have the ability to sell the virus, nor could it be used for anything but research on mice. The thing we can do is supply the gene or amino that the virus is responsible for replicating and producing, in this case FS 344 or follistatin 344, which is practically the same thing to research with, yet giving us more control on the amounts we want to research, and having more control over the FS. There are I think two or three that completed a 10 day research log, in the peptides section.

-T

That clears a lot of fog for me, thanks brother!

Originally Posted by Thresh

That clears a lot of fog for me, thanks brother!

No problemo, check your pms also.

Originally Posted by TwisT

No problemo, check your pms also.

Thank you again sir!