Thread: Follistatin 344 Now is stock - SUPPLIES GOING FAST

ITS FINALLY ARRIVED FOLKS! AFTER A VERY LONG WAIT THE FOLLISTATIN 344 HAS ARRIVED.

THIS IS TRUE FOLLISTATIN 344 AT 98% PURITY.

WE ONLY HAVE 110 OF THESE IN STOCK SO IF YOURE PLANNING ON WAITING ON ORDERING THEN DONT BECAUSE WE WILL PROBABLY RUN OUT BEFORE THE WEEK IS OVER.

YOU CAN ORDER IT HERE!

Originally Posted by TGB1987

Info?

pulled this from the website.

Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FSTgene.[1][2]Follistatin is an autocrineglycoprotein that is expressed in nearly all tissues of higher animals.
It was initially isolated from follicular fluid and was identified as a protein fraction that inhibited follicle-stimulating hormone (FSH) secretion from the anterior pituitary, and so was known as FSH-suppressing protein (FSP). Since then its primary function has been determined to be the binding and bioneutralization agent of members of the TGF-? superfamily, with primary focus on activin, a paracrine hormone (TGF-? member) which enhances secretion of FSH in the anterior pituitary.

Species

Human

Mouse

Entrez
10468
14313
Ensembl
ENSG00000134363
ENSMUSG00000021765
UniProt
P19883
P47931
RefSeq (mRNA)
NM_013409
NM_008046
RefSeq (protein)
NP_006341
NP_032072
Location (UCSC)
Chr 5: 52.81 - 52.82 Mb
Chr 13: 115.24 - 115.25 Mb
PubMed search
[1]
[2]

Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FSTgene.[1][2]Follistatin is an autocrineglycoprotein that is expressed in nearly all tissues of higher animals.[2]
It was initially isolated from follicular fluid and was identified as a protein fraction that inhibited follicle-stimulating hormone (FSH) secretion from the anterior pituitary, and so was known as FSH-suppressing protein (FSP). Since then its primary function has been determined to be the binding and bioneutralization agent of members of the TGF-? superfamily, with primary focus on activin, a paracrine hormone (TGF-? member) which enhances secretion of FSH in the anterior pituitary.
Contents
•1 Biochemistry
•2 Clinical significance
•3 References
•4 Further reading
•5 External links
Biochemistry
Follistatin is part of the inhibin-activin-follistatin axis.
Currently there are three reported isoforms, FS-288, FS-300, and FS-315. Two, FS-288 and FS-315, are known to be created by alternative splicing of the primary mRNA transcript. FS-300 (porcine follistatin) is thought to be the product of posttranslational modification via truncation of the C-terminal domain from the primary amino-acid chain.
Although FS is ubiquitous its highest concentration has been found to be in the female ovary, followed by the skin.
The activin-binding protein follistatin is produced by folliculostellate (FS) cells of the anterior pituitary. FS cells make numerous contacts with the classical endocrine cells of the anterior pituitary including gonadotrophs.
In the tissues activin has a strong role in cellular proliferation, thereby making follistatin the safeguard against uncontrolled cellular proliferation and also allowing it to function as an instrument of cellular differentiation. Both of these roles are vital in tissue rebuilding and repair, and may account for follistatin's high presence in the skin.
In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or pathogenic incursion. The source of follistatin in circulating blood plasma has yet to be determined, but due to its autocrine nature speculation suggests the endothelial cells lining all blood vessels, or the macrophages and monocytes also circulating within the whole blood, may be sources. Follistatin is involved in the development of the embryo. It has inhibitory action on bone morphogenic proteins (BMPs); BMPs induce the ectoderm to become epidermal ectoderm. Inhibition of BMPs allows neuroectoderm to arise from ectoderm, a process which eventually forms the neural plate. Other inhibitors involved in this process are noggin and chordin.
Follistatin and BMPs are also known to play a role in folliculogenesis within the ovary. The main role of follistatin in the oestrus/menstrus ovary, so far, appears to be progression of the follicle from early antral to antral/dominant, and importantly the promotion of cellular differentiation of the estrogen producing granulosa cells (GC) of the dominant follicle into the progesterone producing large lutein cells (LLC) of the corpus luteum.
Clinical significance
Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee &McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.[3][4] In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis.[5]
A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.[6]
It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.

THIS PRODUCT IS NOT FOR HUMAN USE NOR IS IT INTENDED TO TREAT PREVENT OR CURE ANY DISEASES. EXTREME PEPTIDE WILL DENY ANY ORDER IF WE FEEL IT WILL NOT BE USED TO THE CONDITIONS SPECIFIED IN OUR DISCLAIMER WHICH IS AGREED UPON BEFORE ENTERING THE STORE