Thread: Tß4

Product Description

Product Name: TB-500

Size:

Molecular Formula: C212H350N56O78S

Molecular Weight:

CAS:77591-33-4

Sequence (One-Letter Code):

Sequence (Three-Letter Code):Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser


TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (Tß4). It is a first-in-class drug candidate that promotes the following*:

• Endothelial (blood vessels) cell differentiation
• Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
• Keratinocyte migration
• Collagen deposition; and
• Decreases inflammation.

TB-500 offers many benefits to the equine world in performance racing. Recent trials by some of the world’s leading trainers on their prize winning equine members of both genders, have been credited by a huge boost in their race-day results, something long desired in the racing world.

These trials along with clinical trials have indicated the following benefits associated with the use of TB-500 on mares and stallions*:

• Increase muscle growth with huge increases in endurance and strength noted
• Relaxed muscle spasm
• Improved muscle tone
• Increase the exchange of substance between cells
• Encourage tissue repair
• Stretches connective tissue
• Helps maintain flexibility
• Reduces inflammation of tissue in joint
• Enhances nutritional components in the animal
• Prevents the formations of adhesions and fibrous bands in muscles, tendons and ligaments.

T²4 Peptide Research - RegeneRx

http://www.regenerx.com/wt/page/publications


seems like a wonder drug

Hair Growth

It has also been demonstrated that TB4 promotes hair growth in various rat and mice models including a transgenic TB4 overexpressing mouse24. The mechanism by which TB4 acts to promote hair growth is by its stimulatory effects on follicle stem cell growth, migration, differentiation, and protease production.

Anti-Aging Properties

Applied topically on the skin (as a spray or cream), TB4-7b has very potent anti-aging, anti-wrinkle, anti-scarring and wound healing properties. No adverse or unwanted effects have been observed in case studies and in a phase I/II clinical trial involving 30 patients. Applied topically on the scalp, promotion of hair thickness, change in coloration (from grey back to its original darker colour), and hair growth have also been clearly observed.

Large Clinical Trial About to Be Initiated

When injected into patients it promotes activation of circulating and various organ stem cells in a safe manner, leading to a very potent anti-aging effect. Benefits have so far been observed in patients with a variety of degenerative diseases, such as heart disease, neuromuscular disease, diabetes and emphysema, to name a few. A large clinical trial under FDA regulations is about to be initiated on the efficacy of TB4-7 in patients with Type II diabetes, Duchenes Muscular dystrophy and emphysema.

As has been shown in cardiac tissue, TB4-7 promotes the activation of cardiac muscle and endothelial progenitor cells, and their survival, and decreases muscle apoptosis25. Similarly in the cornea, TB4 promotes cell migration and wound healing, has anti-inflammatory properties, and suppresses apoptosis26. Another group's results indicate that TB4 also promotes the survival and neurite outgrowth of cultured spinal cord neurons27. We have observed similar promotive effects of TB4 on the survival and stimulation of skeletal muscle progenitors and myocytes.

Already Used By Body Builders

Human trial candidates have noticed the following in an ongoing trial in body builders where they inject 10mg of TB4-7 twice weekly for four weeks:

•Increased muscle girth.
•Faster recovery time (wear and tear) from training.
•Increased muscular endurance.
•Increased muscular strength.
•Decreased musculoskeletal pain.
•Improved hand-eye coordination.
•Increased energy levels.
•Improved mood (decreased anxiety).
•Improved sleeping patterns.
•Improved concentration span and short-term memory.
•Improved hair growth.
AdiStem TB4-7™ Peptide is an injectable formulation of TB4. A similar formulation has just completed Phase I clinical trials and has been shown to be safe and well-tolerated. The product candidate has been developed to address medical indications where subcutaneous administration is warranted. AdiStem Ltd. is currently planning a Phase I/II clinical trial to evaluate AdiStem TB4-7™ in type II diabetic patients although other indications such as motorneurons disease, emphysema, and Duchene's muscular dystrophy have been identified as potential targets.

Available in a Cream for Hair Growth through ActiStem Ltd.

AdiStem TB4-7™ Peptide is now available in a cream for hair growth. You can purchase or view more information on our distributor's website, ActiStem.com.

About AdiStem Ltd.

Aside from autologous adipose-derived stem cell therapy, AdiStem Ltd. is focused on the discovery and development of novel stem cell derived peptides to accelerate tissue and organ repair. Currently, AdiStem Ltd. is developing a product candidate, TB4-7, for Type II diabetes. AdiStem Ltd. is also developing other product candidates for use on other diseases. These product candidates are based on TB4, a synthetic derivative copy of the 43-amino acid, naturally occurring peptide. AdiStem Ltd. holds and has applied for over 6 world-wide patents and patent applications related to novel peptides to date.

CONTACT US

Telephone: +632 856 5100
Fax: +632 856 9206
Email: info@AdiStem.com

sounds great is this stuff on the market yet ?>

Originally Posted by spaemp3

sounds great is this stuff on the market yet ?>

Yes for research and for horses, camels and dogs. Also its in 3rd phase clinical trials for humans.
But Kynoselen also was only for horses up until bodybuilders started using it and now there is a human version that alot of people love. Nice to see someone that reads. you would think more people would be interested in something like this.

YEP seen this peptide around now. just like u getbig808 im seriously interested in it. seems really promising. supposedly 1-2mg for a 200lb research animal ( ) once a week for 6 weeks. and then just 1-2mg once a month to maintain. seems really really promising bro!

Originally Posted by jayice

YEP seen this peptide around now. just like u getbig808 im seriously interested in it. seems really promising. supposedly 1-2mg for a 200lb research animal ( ) once a week for 6 weeks. and then just 1-2mg once a month to maintain. seems really really promising bro!

0.4mg for a 220lb test subject once a week for 6 weeks. 2mg is for a horse based on the average wieght of a horse is 1100lbs wich is 5x 220. So 2mg divided by 5 is 0.4mg

Originally Posted by getbig808

0.4mg for a 220lb test subject once a week for 6 weeks. 2mg is for a horse based on the average wieght of a horse is 1100lbs wich is 5x 220. So 2mg divided by 5 is 0.4mg

u sure bro. cuz was seeing that its 2mg for a 200lb test subject and 10mg for a horse. u could be right tho...have u researched with this peptide? if so how were the results?

Originally Posted by jayice

u sure bro. cuz was seeing that its 2mg for a 200lb test subject and 10mg for a horse. u could be right tho...have u researched with this peptide? if so how were the results?

looking closer you are right it is 10mg/2ml. i thought it was 10ml/10mg. So you are right 2mg per week or 0.4ml from a 10mg/2ml solution. No i havent tryed it but im getting ready to.

Originally Posted by getbig808

looking closer you are right it is 10mg/2ml. i thought it was 10ml/10mg. So you are right 2mg per week or 0.4ml from a 10mg/2ml solution. No i havent tryed it but im getting ready to.

ok kl mate. ive also heard it only lasts for 7 days then degrades bro . how are u going to reconstitute it bro?

I read 8 but still. Not sure yet. Sure would be nice if we had alittle more help but we arent talking steroids or pickup lines so no one gives a fuck. lol I wonder if i could get say 4 steril vials and seperate it dry then reconstitute one at a time? I need to read more

HOW TO USE TB-500 (Thymosin beta 4):

FOR RESEARCH USE ONLY

Research has shown that the best results are achieved when using sterile saline solution (Sodium Chloride Injection BP 0.9%) to mix TB-500 (thymosin beta4).

Important:
Only prepare the vials that will be used immediately. If using doses that are lower than the recommended dose, prepared vials must be stored in the fridge and be used within 8 days.

Vial preparation:
Remove the plastic protective cap of the sealed vial containing the powder of peptides.
Insert the filled syringe of 2ml of sodium chloride solution into the rubber top of the vial and release the 2ml of sodium chloride into the vial.
Remove the syringe and gently rotate the vial until the powder is completely dissolved.
Ensure that the solution is well mixed with all powder thoroughly dissolved for maximum safety and effectiveness.

Administration:
A Subcutaneous (S/C) inj.

Frequency:
Research studies have further shown that one (2ml. vial) Sub-Q Inj. each week for six consecutive weeks provides the best results. There after, use only one (2ml. vial) per month. It's best to give the Sub-Q Inj. 6 days before intense work outs. Therefore for best results, one vial per Sub-Q injection per week for 6 consecutive weeks, then 1 vial per month (the glass vial is 2ml, with 10mg TB-500 per vial), so it is 10mg/2ml).

Contraindications:
No known contraindications exists with other research peptides, however the product has not been thoroughly tested to know its full contraindications.
The product should not be used if the subject is pregnant or breast feeding.

Storage:
Store the product at room temperature in a non humid environment. An opened vile can be kept for up to 8 days in refrigerated storage.

Stability:
Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored

desiccated below -18

0C. Upon reconstitution Thymosin b4 should be stored at 40C between 2-7 days

and for future use below -18

0C. For long term storage it is recommended to add a carrier protein
(0.1% HSA or BSA). What HSA and BSA? BSA=bactiriostatic?

Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile ddH2O, 0.1% BSA or HSA. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Originally Posted by getbig808

Stability:
Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored

desiccated below -18

0C. Upon reconstitution Thymosin b4 should be stored at 40C between 2-7 days

and for future use below -18

0C. For long term storage it is recommended to add a carrier protein
(0.1% HSA or BSA). What HSA and BSA? BSA=bactiriostatic?

Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile ddH2O, 0.1% BSA or HSA. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

so could it last longer with the use of BSA?

Originally Posted by jayice

so could it last longer with the use of BSA?

Thats the way i see it....

HSA = Human serum albumin. costs about 125.00 for 1g. way more then enough

Originally Posted by getbig808

HSA = Human serum albumin. costs about 125.00 for 1g. way more then enough

wondering how you'll reconstitute it with the HSA. and if u still need the sodium chloride?

actually course i'll need the sodium chloride as the hsa is not a liquid! lool

Originally Posted by jayice

actually course i'll need the sodium chloride as the hsa is not a liquid! lool

It comes allready mixed in a solution of sodium chloride

ok great! this peptideresearch bro?

Originally Posted by jayice

ok great! this peptideresearch bro?

like to start in november. going to vegas to get some strip club money and to watch my home boy bjpenn fight next week so dont want to start or order n not be here.
Im down for november though. also want to run AOD9604 check it out

I think I might run this soon at 2mg a week for 6 weeks.

Originally Posted by maniac0614

I think I might run this soon at 2mg a week for 6 weeks.

Thats whats up... maybe throw in some gw1516

Originally Posted by getbig808

HOW TO USE TB-500 (Thymosin beta 4):

FOR RESEARCH USE ONLY

Research has shown that the best results are achieved when using sterile saline solution (Sodium Chloride Injection BP 0.9%) to mix TB-500 (thymosin beta4).

Important:
Only prepare the vials that will be used immediately. If using doses that are lower than the recommended dose, prepared vials must be stored in the fridge and be used within 8 days.

Vial preparation:
Remove the plastic protective cap of the sealed vial containing the powder of peptides.
Insert the filled syringe of 2ml of sodium chloride solution into the rubber top of the vial and release the 2ml of sodium chloride into the vial.
Remove the syringe and gently rotate the vial until the powder is completely dissolved.
Ensure that the solution is well mixed with all powder thoroughly dissolved for maximum safety and effectiveness.

Administration:
A Subcutaneous (S/C) inj.

Frequency:
Research studies have further shown that one (2ml. vial) Sub-Q Inj. each week for six consecutive weeks provides the best results. There after, use only one (2ml. vial) per month. It's best to give the Sub-Q Inj. 6 days before intense work outs. Therefore for best results, one vial per Sub-Q injection per week for 6 consecutive weeks, then 1 vial per month (the glass vial is 2ml, with 10mg TB-500 per vial), so it is 10mg/2ml).

Contraindications:
No known contraindications exists with other research peptides, however the product has not been thoroughly tested to know its full contraindications.
The product should not be used if the subject is pregnant or breast feeding.

Storage:
Store the product at room temperature in a non humid environment. An opened vile can be kept for up to 8 days in refrigerated storage.

Good info but for people who dont know, that is the dosage for a horse not a human.

Originally Posted by maniac0614

Good info but for people who dont know, that is the dosage for a horse not a human.

But this is not for human useresearch yeahya

thinking of using it with actn3. have u heard of that peptide bro?

Phil Hernon's Muscle Science :: Science Beyond Bodybuilding :: Bodybuilding Forums

u started using the peptide bro?