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#1 |
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Guardian of The Homeland
Super Moderator
Join Date: Jan 2002
Location: Charlotte NC
Posts: 17,158
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Tmm-100(Norbolone-17-ether - how it is legal)
Details are coming in a second about this new Deca compound that is Not a Prohormone, but first, here’s why this information is vitally important to you, especially in this day and age of incredible new breakthroughs concerning sports supplements.
If you’ve been involved in bodybuilding for any length of time, it’s no secret there are numerous supplements on the market today, that just a few years ago were completely unknown to the vast majority of bodybuilders. All the various prohormones, prosteroids like T-100, the new cyclodextrin delivery systems, methoxyisoflavones, 20 hydroxyecysterones, thyroid hormones, nor-ephedrine, and the list goes on and on. In some countries throughout the world, these compounds are prescription only! And with increasing frequency our government is banning some of them at a moment’s notice. In fact, the California Attorney General’s Office has just filed lawsuits against nearly a dozen California supplement companies over the sale of prohormones. Who knows what’s next . . . so stay informed. This is crucial because today the line between what’s legal and what’s not is becoming a darker shade of gray almost on a weekly basis . . . so not only do you need to know the bio-chemical aspect of a new supplement . . . you also need to be updated on its legal status as well! Happy reading! This month features an exciting new discovery concerning the most popular anabolic of all time, nandrolone decanoate, more commonly known as Deca. In a nutshell, this informative article will reveal a gaping loophole in the law that allows for the sale of a very similar nandrolone called norbolone-17-ether. It is not the common prohormone, “19 norandrostenedione or diol” that first convert (and often poorly!) before turning into nandrolone (19-Nortestosterone) . . . but the real thing! In fact, norbolone-17- ether causes the identical anabolic properties as injectable Deca! Your first thought is undoubtedly, “how on earth is it possible for norbolone-17-ether to be legal? This will be covered in detail a little later, but first, it’s important to back track a little and take a brief history lesson on Deca so you can clearly understand why it’s the most used anabolic steroid in history. This may come as a surprise to you but the basic structure of nandrolone was first synthesized all the way back in 1936 by German scientists who laid the foundation for all modern day steroid research. The findings of nandrolone (19-Nortestosterone) indicated that the use of nandrolone in debilitated patients would serve as an impetus for new drug developments to come. In 1956 Searle received approval for their drug invention Nilevar (norethandrolone) which indicated no significant toxicity to the drug. The drug was found to be beneficial in treating nutritionally depleted underweight men as well as to hasten the convalescence (to be strong) of hospitalized children. But the “Deca phenomenon” didn’t catch on until 1976 when Van der Vies and Johannes introduced the now famous, nandrolone decanoate, a much longer acting nandrolone ester that needs to be injected just once every 14-21 days. (However, most bodybuilders inject it once a week.) It was clear to the scientists that the design of the perfect orally active steroid would involve the inclusion of a Methyl group at the 17th position to essentially prevend the oxidation of the drug by the liver. This modification, however, results to some degree of hepatotoxicity, which is correlated with a reduction in HDL (good cholesterol). So the investigation of more safer alternatives continued which resulted in the discovery of todays ether technology (the replacement of the methyl group by an ether). But before elaborating more on technicalities and pharmacokinetics, let’s take a close look at why Deca is so popular. It has two very distinct, and about half a dozen other positive things it does for somebody looking to acquire lots of quick muscle and power. First, Deca has massive nitrogen retention qualities that are not exceeded by any other anabolic. As you may know, nitrogen, in bound form, is protein. Deca causes the muscle cell to store more nitrogen than it releases, thus putting the muscle cell in what is called a “positive nitrogen”, or protein sparing balance. And since muscle is essentially protein, the more protein, the bigger the muscle gets. Its second very distinct feature is its amazing lipotropic effects, meaning it burns fat like mad. Virtually everyone who uses Deca in high dosages (200 - 400 mg a week) notices startling changes in body composition. They take on a sinewy, very defined appearance that is virtually impossible to get “naturally”. Scientists don’t know exactly why Deca has such a profound impact on body composition, but they speculate that it’s largely due to its powerful nutrient-partitioning-effects, that shuttle all nutrients including carbohydrates and fat into the muscle cell where they are swiftly metabolized to assist the muscle building process. Deca’s incredible dual combination of causing rapidly enlarging, yet much leaner muscle tissue, is unmatched by any other single steroid in the world. And it doesn’t stop here. Deca also has the unsurpassed ability to store water in “connective tissue” which effectively alleviates pain in the joints. This is especially useful to athletes who suffer from shoulder, elbow or knee problems due to many years of “tearing it up” in the gym with heavy weights. Another major benefit of Deca is believed to be extremely anti-catabolic, meaning it blocks the build up of cortisol, a catabolic (breakdown) hormone that can completely stop muscle growth. You get big, cut, recover overnight, and get joints as loose as a baby kangaroo’s . . . no wonder Deca has been rated #1 by bodybuilders and athletes the world over since 1960! OK, now that you have a little background on Deca, let’s get to the best part about the new nandrolone that’s orally active! Here’s where it gets tricky, so please pay very special attention. Norbolone-17-ether is legal because it has what’s called an “ether side chain” attached to its steroid skeleton. Think of this side chain as a chemical messenger of sorts that directs the way a steroid is metabolized by the body. For example, almost every oral active steroid is 17-alpha-alkylated . . . which means that they are chemically designated not to be broken down by the liver, where they’re metabolized. This is why 17-alpha-alkylated steroids are hard on the liver. This special sidebar keeps the steroid active in the liver, blocking liver enzymes from reacting with the steroid skeleton. All oral 17-alpha-alkylated steroids are illegal and prescription only. However, what if a scientist attached a different side chain to the basic norbolone steroid skeleton . . . not only would it be legal (since it now becomes a distinctly different compound) it would also be a lot less toxic to the liver. This is exactly the case with norbolone-17-ether. Here’s how it came about. Scientists have known for a long time that 17-alpha-alkylated steroids like Dianabol and Methyl-Test were effective in the treading a condition called HAE, Hereditary Angioedema. (A disease where fluid escapes from blood vessels into surrounding tissues). The problem however, (and you now know this) . . . is these types of steroids are hepatotoxic, medical terminology for “tough on the liver” . . . especially tough on elderly people’s livers who need them to treat HAE. So what scientists did was to modify the side chains of various steroids, including norbolone to see if they could administer them to treat HAE without alkylating them. The result was norbolone-17-ether an orally active steroid that is not 17-alpha-alkylated. As you may recall, a side chain effects the delivery of a steroid into the bloodstream. In this case, the ether side chain has a strong affinity to attach to fats. Technically this is called “lipophilic” meaning fat loving. Therefore, norbolone-17-ether is absorbed in the same manner as dietary fats which latch on to tiny carrier proteins called chylomicra, which are then transported through the lymphatic system into the bloodstream. Now obviously you just read a lot of terms you may not be familiar with . . . but basically this means scientists have found a way to orally administer norbolone (a new nandrolone compound that is currently not regulated)! And by doing so, they also opened up a gaping loophole in the law that allows its sale without a prescription. It’s true! This new norbolone-17-ether, by the letter of the law, is amazingly . . . legal because it’s technically not the same as nandrolone deconate. Remember this is not a prohormone converting process, because norbolone-17-ether is not a prohormone. Details are coming in a second about this new Deca compound that is Not a Prohormone, but first, here’s why this information is vitally important to you, especially in this day and age of incredible new breakthroughs concerning sports supplements. If you’ve been involved in bodybuilding for any length of time, it’s no secret there are numerous supplements on the market today, that just a few years ago were completely unknown to the vast majority of bodybuilders. All the various prohormones, prosteroids like T-100, the new cyclodextrin delivery systems, methoxyisoflavones, 20 hydroxyecysterones, thyroid hormones, nor-ephedrine, and the list goes on and on. In some countries throughout the world, these compounds are prescription only! And with increasing frequency our government is banning some of them at a moment’s notice. In fact, the California Attorney General’s Office has just filed lawsuits against nearly a dozen California supplement companies over the sale of prohormones. Who knows what’s next . . . so stay informed. This is crucial because today the line between what’s legal and what’s not is becoming a darker shade of gray almost on a weekly basis . . . so not only do you need to know the bio-chemical aspect of a new supplement . . . you also need to be updated on its legal status as well! Happy reading! This month features an exciting new discovery concerning the most popular anabolic of all time, nandrolone decanoate, more commonly known as Deca. In a nutshell, this informative article will reveal a gaping loophole in the law that allows for the sale of a very similar nandrolone called norbolone-17-ether. It is not the common prohormone, “19 norandrostenedione or diol” that first convert (and often poorly!) before turning into nandrolone (19-Nortestosterone) . . . but the real thing! In fact, norbolone-17- ether causes the identical anabolic properties as injectable Deca! Your first thought is undoubtedly, “how on earth is it possible for norbolone-17-ether to be legal? This will be covered in detail a little later, but first, it’s important to back track a little and take a brief history lesson on Deca so you can clearly understand why it’s the most used anabolic steroid in history. This may come as a surprise to you but the basic structure of nandrolone was first synthesized all the way back in 1936 by German scientists who laid the foundation for all modern day steroid research. The findings of nandrolone (19-Nortestosterone) indicated that the use of nandrolone in debilitated patients would serve as an impetus for new drug developments to come. In 1956 Searle received approval for their drug invention Nilevar (norethandrolone) which indicated no significant toxicity to the drug. The drug was found to be beneficial in treating nutritionally depleted underweight men as well as to hasten the convalescence (to be strong) of hospitalized children. But the “Deca phenomenon” didn’t catch on until 1976 when Van der Vies and Johannes introduced the now famous, nandrolone decanoate, a much longer acting nandrolone ester that needs to be injected just once every 14-21 days. (However, most bodybuilders inject it once a week.) It was clear to the scientists that the design of the perfect orally active steroid would involve the inclusion of a Methyl group at the 17th position to essentially prevend the oxidation of the drug by the liver. This modification, however, results to some degree of hepatotoxicity, which is correlated with a reduction in HDL (good cholesterol). So the investigation of more safer alternatives continued which resulted in the discovery of todays ether technology (the replacement of the methyl group by an ether). But before elaborating more on technicalities and pharmacokinetics, let’s take a close look at why Deca is so popular. It has two very distinct, and about half a dozen other positive things it does for somebody looking to acquire lots of quick muscle and power. First, Deca has massive nitrogen retention qualities that are not exceeded by any other anabolic. As you may know, nitrogen, in bound form, is protein. Deca causes the muscle cell to store more nitrogen than it releases, thus putting the muscle cell in what is called a “positive nitrogen”, or protein sparing balance. And since muscle is essentially protein, the more protein, the bigger the muscle gets. Its second very distinct feature is its amazing lipotropic effects, meaning it burns fat like mad. Virtually everyone who uses Deca in high dosages (200 - 400 mg a week) notices startling changes in body composition. They take on a sinewy, very defined appearance that is virtually impossible to get “naturally”. Scientists don’t know exactly why Deca has such a profound impact on body composition, but they speculate that it’s largely due to its powerful nutrient-partitioning-effects, that shuttle all nutrients including carbohydrates and fat into the muscle cell where they are swiftly metabolized to assist the muscle building process. Deca’s incredible dual combination of causing rapidly enlarging, yet much leaner muscle tissue, is unmatched by any other single steroid in the world. And it doesn’t stop here. Deca also has the unsurpassed ability to store water in “connective tissue” which effectively alleviates pain in the joints. This is especially useful to athletes who suffer from shoulder, elbow or knee problems due to many years of “tearing it up” in the gym with heavy weights. Another major benefit of Deca is believed to be extremely anti-catabolic, meaning it blocks the build up of cortisol, a catabolic (breakdown) hormone that can completely stop muscle growth. You get big, cut, recover overnight, and get joints as loose as a baby kangaroo’s . . . no wonder Deca has been rated #1 by bodybuilders and athletes the world over since 1960! OK, now that you have a little background on Deca, let’s get to the best part about the new nandrolone that’s orally active! Here’s where it gets tricky, so please pay very special attention. Norbolone-17-ether is legal because it has what’s called an “ether side chain” attached to its steroid skeleton. Think of this side chain as a chemical messenger of sorts that directs the way a steroid is metabolized by the body. For example, almost every oral active steroid is 17-alpha-alkylated . . . which means that they are chemically designated not to be broken down by the liver, where they’re metabolized. This is why 17-alpha-alkylated steroids are hard on the liver. This special sidebar keeps the steroid active in the liver, blocking liver enzymes from reacting with the steroid skeleton. All oral 17-alpha-alkylated steroids are illegal and prescription only. However, what if a scientist attached a different side chain to the basic norbolone steroid skeleton . . . not only would it be legal (since it now becomes a distinctly different compound) it would also be a lot less toxic to the liver. This is exactly the case with norbolone-17-ether. Here’s how it came about. Scientists have known for a long time that 17-alpha-alkylated steroids like Dianabol and Methyl-Test were effective in the treading a condition called HAE, Hereditary Angioedema. (A disease where fluid escapes from blood vessels into surrounding tissues). The problem however, (and you now know this) . . . is these types of steroids are hepatotoxic, medical terminology for “tough on the liver” . . . especially tough on elderly people’s livers who need them to treat HAE. So what scientists did was to modify the side chains of various steroids, including norbolone to see if they could administer them to treat HAE without alkylating them. The result was norbolone-17-ether an orally active steroid that is not 17-alpha-alkylated. As you may recall, a side chain effects the delivery of a steroid into the bloodstream. In this case, the ether side chain has a strong affinity to attach to fats. Technically this is called “lipophilic” meaning fat loving. Therefore, norbolone-17-ether is absorbed in the same manner as dietary fats which latch on to tiny carrier proteins called chylomicra, which are then transported through the lymphatic system into the bloodstream. Now obviously you just read a lot of terms you may not be familiar with . . . but basically this means scientists have found a way to orally administer norbolone (a new nandrolone compound that is currently not regulated)! And by doing so, they also opened up a gaping loophole in the law that allows its sale without a prescription. It’s true! This new norbolone-17-ether, by the letter of the law, is amazingly . . . legal because it’s technically not the same as nandrolone deconate. Remember this is not a prohormone converting process, because norbolone-17-ether is not a prohormone. Norbolone-17-ether is now available through S.A.N. under the patent pending Norbolone-ether technology and is called TMM-100 and supplies are limited… Be one of the first 5000 lucky customers that is able to take advantage of this limited supply loophole which might soon be closed. . . we’ll keep you posted. is now available through S.A.N. under the patent pending Norbolone-ether technology and is called TMM-100 and supplies are limited… Be one of the first 5000 lucky customers that is able to take advantage of this limited supply loophole which might soon be closed. . . we’ll keep you posted. |
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#2 |
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Registered User
Join Date: Jun 2002
Location: Raleigh NC
Posts: 116
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so what about this problem that I've heard about where SAN is having trouble with their new pro-anabolics converting while in the capsule. Therefore, any converted substance would be destroyed in the liver?
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